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Effect of Kombucha on gut-microbiota in mouse having non-alcoholic fatty liver disease

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver disorders. Possible links have been recently found between the gut-microbiota and the host metabolism in development of NAFLD and obesity. Therefore, understanding the changes in intestinal microbiota during the progression of NAFLD, is important. In this study, the effect of Kombucha tea (KT), obtained by microbial fermentation of sugared black tea, was investigated on gut-microbiota during the progression of NAFLD. The results indicated a decrease in Erysipelotrichia class by treatment with KT in comparison to the methionine/choline-deficient (MCD)-fed db/db mice. Allobaculum, Turicibacter, and Clostridium genera, were only detected in MCD-fed db/db mice and were decreased after treatment with KT, whereas Lactobacillus was more abundant in MCD + KT-fed mice than in MCD only-fed mice and Mucispirillum, was found only in the MCD + KT-fed mice group. Our results demonstrated that the change of intestinal microbiota was influenced by KT intake, contributing to combat NAFLD.

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Acknowledgements

This work was supported by a 2-year Research Grant of Pusan National University (Y.-S.S.).

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Authors and Affiliations

  1. Department of Integrated Biological Science, Pusan National University, Busan, 46241, Korea

    Youngmi Jung, Inyoung Kim, Mohamed Mannaa, Jinnyun Kim, Sihyung Wang, Jieun Kim & Young-Su Seo

  2. Department of Asian Food and Culinary Arts, Youngsan University, Busan, 48015, Korea

    Inmyoung Park

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  1. Youngmi Jung
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  2. Inyoung Kim
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  3. Mohamed Mannaa
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  4. Jinnyun Kim
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Correspondence to Young-Su Seo.

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Jung, Y., Kim, I., Mannaa, M. et al. Effect of Kombucha on gut-microbiota in mouse having non-alcoholic fatty liver disease. Food Sci Biotechnol 28, 261–267 (2019). https://doi.org/10.1007/s10068-018-0433-y

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  • DOI: https://doi.org/10.1007/s10068-018-0433-y

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