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Hypolipidemic effect of soluble dietary fibers prepared from Asparagus officinalis and their effects on the modulation of intestinal microbiota

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Abstract

The soluble dietary fiber from Asparagus officinalis (ASDF) was successively prepared using enzymolysis combined with spray-drying technology. High-performance liquid chromatography analysis showed that ASDF contained two polysaccharide fractions with the average molecular weight of 2.77 × 105 and 6.44 × 103 Da, and was composed of mannose, rhamnose, galacturonic acid, glucose, galactose, and arabinose with a molecular ratio of 19.93:1.02:1.94:32.17:1.00:1.91, respectively. ASDF showed potential in vitro antioxidant activities. The oral administration of ASDF significantly reduced the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol in HD-induced mice serum. Furthermore, 16S rRNA gene sequencing analysis showed that ASDF significantly affected the composition of intestinal microbiota, especially reducing the Firmicutes/Bacteroidotetes ratio and the relative abundances of Desulfobacterota, Proteobacteria, Actinobacteriota and increasing that of Muribaculaceae, Bacteroides, and Alloprevotella. These results demonstrated that the intake of ASDF could regulate intestinal microbiota and serum lipid levels in hyperlipidemic conditions.

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Acknowledgements

The work was supported financially by the National Key R&D Program of China (2018YFC0311206), Science, education and industry integration and innovation pilot project of Qilu University of Technology (2020KJC-ZD15).

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Authors and Affiliations

  1. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, Shandong, People’s Republic of China

    Miansong Zhang, Mengke Yao, Airong Jia, Yaping Shi, Xinfeng Bai, Xue Liu, Tingting Cui, Xin Liu & Changheng Liu

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  1. Miansong Zhang
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  2. Mengke Yao
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  3. Airong Jia
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  4. Yaping Shi
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  8. Xin Liu
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Correspondence to Xin Liu.

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Zhang, M., Yao, M., Jia, A. et al. Hypolipidemic effect of soluble dietary fibers prepared from Asparagus officinalis and their effects on the modulation of intestinal microbiota. Food Sci Biotechnol 30, 1721–1731 (2021). https://doi.org/10.1007/s10068-021-01001-y

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