Skip to main content
Log in

Successful treatment of cannabinoid administration against refractory epilepsy in Batten disease: a case report

  • Letter to the Editor
  • Published:
Neurological Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Devinsky O, Cross JH, Laux L, Marsh E, Miller I, Nabbout R, Scheffer IE, Thiele EA, Wright S, Cannabidiol in Dravet Syndrome Study Group (2017) Trial of cannabidiol for drug-resistant seizures in the dravet syndrome. N Engl J Med 376:2011–2020. https://doi.org/10.1056/NEJMoa1611618

    Article  CAS  PubMed  Google Scholar 

  2. Dolisca S-B, Mehta M, Pearce DA, Mink JW, Maria BL (2013) Batten disease: clinical aspects, molecular mechanisms, translational science, and future directions. J Child Neurol 28:1074–1100. https://doi.org/10.1177/0883073813493665

    Article  PubMed  PubMed Central  Google Scholar 

  3. Mole SE, Cotman SL (2015) Genetics of the neuronal ceroid lipofuscinoses (Batten disease). Biochim Biophys Acta 1852:2237–2241. https://doi.org/10.1016/j.bbadis.2015.05.011

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Reddy DS, Golub VM (2016) The pharmacological basis of cannabis therapy for epilepsy. J Pharmacol Exp Ther 357:45–55. https://doi.org/10.1124/jpet.115.230151

    Article  CAS  PubMed  Google Scholar 

  5. Rocha L, Frías-Soria CL, Ortiz JG, Auzmendi J, Lazarowski A (2020) Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy? Epilepsia Open 5:36–49

    Article  Google Scholar 

  6. Szaflarski JP, Bebin EM (2014) Cannabis, cannabidiol, and epilepsy--from receptors to clinical response. Epilepsy Behav 41:277–282. https://doi.org/10.1016/j.yebeh.2014.08.135

    Article  PubMed  Google Scholar 

  7. Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, Miller I, Flamini R, Wilfong A, Filloux F, Wong M, Tilton N, Bruno P, Bluvstein J, Hedlund J, Kamens R, Maclean J, Nangia S, Singhal NS, Wilson CA, Patel A, Cilio MR (2016) Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol 15:270–278. https://doi.org/10.1016/S1474-4422(15)00379-8

    Article  CAS  PubMed  Google Scholar 

  8. Devinsky O, Patel AD, Cross JH, Villanueva V, Wirrell EC, Privitera M, Greenwood SM, Roberts C, Checketts D, VanLandingham K, Zuberi SM, GWPCARE3 Study Group (2018) Effect of cannabidiol on drop seizures in the Lennox–Gastaut syndrome. N Engl J Med 378:1888–1897. https://doi.org/10.1056/NEJMoa1714631

    Article  CAS  PubMed  Google Scholar 

  9. McCoy B, Wang L, Zak M, al-Mehmadi S, Kabir N, Alhadid K, McDonald K, Zhang G, Sharma R, Whitney R, Sinopoli K, Snead OC III (2018) A prospective open-label trial of a CBD/THC cannabis oil in dravet syndrome. Ann Clin Transl Neurol 5:1077–1088. https://doi.org/10.1002/acn3.621

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Panayiotis Maghsoudlou.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this case report involving human participants were in accordance with the ethical standards of the institutional committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Consent to participate

Informed consent was obtained from legal guardians.

Consent to publish

The participant has consented to the submission of the case report to the journal.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Georgiou, F., Maghsoudlou, P., Loukaidis, P. et al. Successful treatment of cannabinoid administration against refractory epilepsy in Batten disease: a case report. Neurol Sci 42, 1203–1206 (2021). https://doi.org/10.1007/s10072-020-04763-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-020-04763-1

Navigation