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Effect of low-level laser therapy on the healing process of donor site in patients with grade 3 burn ulcer after skin graft surgery (a randomized clinical trial)

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Abstract

Skin graft is a standard therapeutic technique in patients with deep ulcers, but managing donor site after grafting is very important. Although several modern dressings are available to enhance the comfort of donor site, using techniques that accelerate wound healing may enhance patient satisfaction. Low-level laser therapy (LLLT) has been used in several medical fields, including healing of diabetic, surgical, and pressure ulcers, but there is not any report of using this method for healing of donor site in burn patients. The protocols and informed consent were reviewed according to Medical Ethics Board of Shahid Beheshti University of Medical Sciences (IR.SBMU.REC.1394.363) and Iranian Registry of Clinical Trials (IRCT2016020226069N2). Eighteen donor sites in 11 patients with grade 3 burn ulcer were selected. Donor areas were divided into 2 parts, for laser irradiation and control randomly. Laser area was irradiated by a red, 655-nm laser light, 150 mW, 2 J/cm2, on days 0 (immediately after surgery), 3, 5, and 7. Dressing and other therapeutic care for both sites were the same. The patients and the person who analyzed the results were blinded. The size of donor site reduced in both groups during the 7-day study period (P < 0.01) and this reduction was significantly greater in the laser group (P = 0.01). In the present study, for the first time, we evaluate the effects of LLLT on the healing process of donor site in burn patients. The results showed that local irradiation of red laser accelerates wound healing process significantly.

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Acknowledgments

We extend our gratitude to the staff of Motahari Burn Center for their assistance.

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Authors and Affiliations

  1. Burn Research center, Department of Plastic and Reconstructive Surgery, Iran University of Medical Sciences, Tehran, Iran

    Reza Vaghardoost, Mahnoush Momeni, Mostafa Dahmardehei, Parisa Sabr joo, Sara Mey Abadi & Soheila Naderi Gharagheshlagh

  2. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Nooshafarin Kazemikhoo & Mohammad Ali Nilforoushzadeh

  3. Canadian Optic and Laser Center, Victoria, BC, Canada

    Soheila Mokmeli

  4. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Fereshteh Ansari

  5. Al Nasr Sport Club Medical Section, Dubai, United Arab Emirates

    Saeed Sassani

Authors
  1. Reza Vaghardoost
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  2. Mahnoush Momeni
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  3. Nooshafarin Kazemikhoo
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  4. Soheila Mokmeli
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  5. Mostafa Dahmardehei
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  6. Fereshteh Ansari
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  7. Mohammad Ali Nilforoushzadeh
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  8. Parisa Sabr joo
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  9. Sara Mey Abadi
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  10. Soheila Naderi Gharagheshlagh
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  11. Saeed Sassani
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Corresponding author

Correspondence to Mahnoush Momeni.

Ethics declarations

The protocols and informed consent were reviewed according to Medical Ethics Board of Shahid Beheshti University of Medical Sciences (IR.SBMU.REC.1394.363) and Iranian Registry of Clinical Trials (IRCT2016020226069N2).

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The authors declare that they have no conflict of interest.

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Vaghardoost, R., Momeni, M., Kazemikhoo, N. et al. Effect of low-level laser therapy on the healing process of donor site in patients with grade 3 burn ulcer after skin graft surgery (a randomized clinical trial). Lasers Med Sci 33, 603–607 (2018). https://doi.org/10.1007/s10103-017-2430-4

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  • DOI: https://doi.org/10.1007/s10103-017-2430-4

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