Abstract
Idiopathic intracranial hypertension (IIH) is a rare disease with an incidence rate of 0.5–2.0/100,000/year. Characteristic symptoms are headache and several degrees of visual impairment. Psychiatric symptoms in association with IIH are usually poorly described and underestimated. In this study, we evaluated IIH subjects to determine the association with psychiatric symptoms. We evaluated thirty consecutive patients with IIH submitted to neurosurgery from January 2017 to January 2020 in two Brazilian tertiary hospitals. They underwent clinical evaluation, obtaining medical history, comorbidities, body mass index (BMI—kg/m2), and applying Neuropsychiatric Inventory Questionnaire (NPI-Q). There were 28 females and 2 males. Ages ranged from 18 to 66 years old, with mean age of 37.97 ± 12.78. Twenty-five (83%) presented comorbidities, being obese and having arterial hypertension the most frequent. Body mass index ranged from 25 to 35 kg/m2 and mean value was 31 ± 3.42. After application of Neuropsychiatric Interview, 26 of 30 presented psychiatric symptoms (86%). Depression-anxiety syndromes were reported in 25 patients (83%). Nighttime disturbances were reported by 14 subjects (46%). Appetite and eating disorders were described by 23 (76%). Psychiatric symptoms in association with IIH are usually poorly described and underestimated. In our sample, twenty-six out of 30 (86%) reported psychiatric symptoms. We highlight the high prevalence of psychiatric symptoms among IIH patients and the need of managing these patients with a multidisciplinary team, including psychiatrists.
Similar content being viewed by others
References
Oliveira MF, Oliveira JR, Rotta JM, Pinto FC (2014) Psychiatric symptoms are present in most of the patients with idiopathic normal pressure hydrocephalus. Arq Neuropsiquiatr 72(6):435–438
Gurney SP, Ramalingam S, Thomas A, Sinclair AJ, Mollan SP (2020) Exploring the current management idiopathic intracranial hypertension, and understanding the role of dural venous sinus stenting. Eye Brain 12:1–13
Mitchell JL, Mollan SP, Vijay V, Sinclair AJ (2019) Novel advances in monitoring and therapeutic approaches in idiopathic intracranial hypertension. Curr Opin Neurol 32(3):422–431
Giridharan N, Patel SK, Ojugbeli A, Nouri A, Shirani P, Grossman AW, Cheng J, Zuccarello M, Prestigiacomo CJ (2018) Understanding the complex pathophysiology of idiopathic intracranial hypertension and the evolving role of venous sinus stenting: a comprehensive review of the literature. Neurosurg Focus 45(1):E10
Mollan SP, Hornby C, Mitchell J, Sinclair AJ (2018) Evaluation and management of adult idiopathic intracranial hypertension. Pract Neurol 18(6):485–488
Mollan SP, Davies B, Silver NC, Shaw S, Mallucci CL, Wakerley BR, Krishnan A, Chavda SV, Ramalingam S, Edwards J, Hemmings K, Williamson M, Burdon MA, Hassan-Smith G, Digre K, Liu GT, Jensen RH, Sinclair AJ (2018) Idiopathic intracranial hypertension: consensus guidelines on management. J Neurol Neurosurg Psychiatry 89(10):1088–1100
Hoffmann J, Mollan SP, Paemeleire K, Lampl C, Jensen RH, Sinclair AJ (2018) European headache federation guideline on idiopathic intracranial hypertension. J Headache Pain 19(1):93
Puustinen T, Tervonen J, Avellan C, Jyrkkänen HK, Paterno JJ, Hartikainen P, Vanhanen U, Leinonen V, Lehto SM, Elomaa AP, Huttunen TJ (2019) Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension. Clin Neurol Neurosurg 186:105527
Raggi A, Marzoli SB, Chiapparini L, Ciasca P, Erbetta A, Faragò G, Grazzi L, Leonardi M, D’Amico D (2018) Headache frequency and symptoms of depression as predictors of disability in patients with idiopathic intracranial hypertension. Neurol Sci 39(Suppl 1):139–140
Mollan SP, Ali F, Hassan-Smith G, Botfield H, Friedman DI, Sinclair AJ (2016) Evolving evidence in adult idiopathic intracranial hypertension: pathophysiology and management. J Neurol Neurosurg Psychiatry 87(9):982–992
Salzbrenner S, Conaway E (2009) Misdiagnosed bipolar disorder reveals itself to be posttraumatic stress disorder with comorbid pseudotumor cerebri: a case report. Psychiatry (Edgmont) 6(8):29–32
Kuzman MR, Jovanovic N, Vukelja D, Medved V, Hotujac L (2008) Psychiatric symptoms in idiopathic intracranial hypertension. Psychiatry Clin Neurosci 62(3):367
Duggal HS (2005) Idiopathic intracranial hypertension presenting with psychiatric symptoms. J Neuropsychiatr Clin Neurosci 17(3):426–427
Giuseffi V, Wall M, Siegel PZ, Rojas PB (1991) Symptoms and disease associations in idiopathic intracranial hypertension (pseudotumor cerebri): a case-control study. Neurology 41(2 ( Pt 1)):239–244
Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J (1994) The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology 44:2308–2314
Camozzato AL, Kochhann R, Simeoni C et al (2008) Reliability of the Brazilian Portuguese version of the Neuropsychiatric Inventory (NPI) for patients with Alzheimer’s disease and their caregivers. Int Psychogeriatr 20:383–393
Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, Lopez OL, DeKosky ST (2000) Validation of the NPI-Q, a brief clinical form of the neuropsychiatric inventory. J Neuropsychiatr Clin Neurosci 12:233–239
Lai CK (2014) The merits and problems of Neuropsychiatric Inventory as an assessment tool in people with dementia and other neurological disorders. Clin Interv Aging 9:1051–1061
Camozzato AL, Godinho C, Kochhann R, Massochini G, Chaves ML (2015) Validity of the Brazilian version of the Neuropsychiatric Inventory Questionnaire (NPI-Q). Arq Neuropsiquiatr 73(1):41–45
Piper RJ, Kalyvas AV, Young AM, et al. (2015) Interventions for idiopathic intracranial hypertension. Cochrane Database Syst Rev CD003434
Kleinschmidt JJ, Digre KB, Hanover R (2000) Idiopathic intracranial hypertension: Relationship to depression, anxiety, and quality of life. Neurology 54(2):319–324. https://doi.org/10.1212/wnl.54.2.319 (0028-3878 (Print); 0028-3878
Yri HM, Fagerlund B, Jensen RH (2014) Cognitive function in idiopathic intracranial hypertension: a prospective casecontrol study. BMJ Open 4(4):e004376. https://doi.org/10.1136/bmjopen-2013-004376 (2044-6055 (Print); 2044-6055
Kaplan CP, Miner ME, McGregor JM (1997) Pseudotumour cerebri: risk for cognitive impairment? Brain Inj 11(4):293–303 (0269-9052 (Print); 0269-9052
Sorensen PS, Thomsen AM, Gjerris F (1986) Persistent disturbances of cognitive functions in patients with pseudotumor cerebri. Acta Neurol Scand 73(3):264–268 (0001-6314 (Print); 0001-6314
Zur D, Naftaliev E, Kesler A (2015) Evidence of multidomain mild cognitive impairment in idiopathic intracranial hypertension. J Neuroophthalmol 35(1):26–30
Bruce BB, Digre KB, McDermott MP, Schron EB, Wall M (2016) Quality of life at 6 months in the idiopathic intracranial hypertension treatment trial. Neurology. 87(18):1871–1877
Mulla Y, Markey KA, Woolley RL et al (2015) Headache determines quality of life in idiopathic intracranial hypertension. J Headache Pain 16:521
Kesler A, Mosek A, Fithlicher N, Gidron Y (2005) Psychological correlates of idiopathic intracranial hypertension. Isr Med Assoc J 7:627–630
Friedman DI, Liu GT, Digre KB (2013) Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children. Neurology 81(13):1159–1165. https://doi.org/10.1212/WNL.0b013e3182a55f17
Kalyvas A, Neromyliotis E, Koutsarnakis C, Komaitis S, Drosos E, Skandalakis GP, Pantazi M, Gobin YP, Stranjalis G, Patsalides A (2020) A systematic review of surgical treatments of idiopathic intracranial hypertension (IIH). Neurosurg Rev 25
Krakowski AC, O’Halloran HS, Friedlander SF (2007) A female adolescent with headache, change in vision, and hearing of ‘squeaking’ noises. Pediatr Ann 36:145–148
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
Not applicable (review)
Informed consent
Not applicable (review)
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
de Oliveira, M.F., Yamashita, R.H.G., Boa Sorte, A.A. et al. Psychiatric symptoms are frequent in idiopathic intracranial hypertension patients. Neurosurg Rev 44, 1183–1189 (2021). https://doi.org/10.1007/s10143-020-01321-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10143-020-01321-3