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Impact of transporter-mediated drug absorption, distribution, elimination and drug interactions in antimicrobial chemotherapy

  • REVIEW ARTICLE
  • Published:
Journal of Infection and Chemotherapy

Abstract

A comprehensive list of drug transporters has recently become available as a result of extensive genome analysis. Membrane transporters play important roles in determining the pharmacokinetic aspects of intestinal absorption, tissue distribution, and the urinary and biliary excretions of a wide variety of therapeutic drugs. The identification and characterization of transporters responsible for the transfer of nutrients and xenobiotics, including drugs, is expected to provide a scientific basis for understanding drug disposition, as well as the molecular mechanisms of drug–drug/drug–food/drug–protein interactions and inter-individual/inter-species differences. This review focuses on the influence of transporters on the pharmacokinetics of β-lactam antibiotics, new quinolones, and other antimicrobial agents, as well as focusing on the drug–drug interactions associated with transporter-mediated uptake from the small intestine and transporter-mediated elimination from the kidney and liver.

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  1. Akira Tsuji

    Present address: , Kakuma-machi, Kanazawa, 920-1192, Japan

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  1. Department of Molecular Pharmaceutics, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan

    Akira Tsuji

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Tsuji, A. Impact of transporter-mediated drug absorption, distribution, elimination and drug interactions in antimicrobial chemotherapy. J Infect Chemother 12, 241–250 (2006). https://doi.org/10.1007/s10156-006-0478-3

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