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Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus

  • Surveillance
  • Published:
Journal of Infection and Chemotherapy

Abstract

The Japanese surveillance committee conducted the first nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for female acute uncomplicated cystitis at 43 hospitals throughout Japan from April 2009 to November 2010. In this study, the causative bacteria (Escherichia coli and Staphylococcus saprophyticus) and their susceptibility to various antimicrobial agents were investigated by isolation and culturing of bacteria from urine samples. In total, 387 strains were isolated from 461 patients, including E. coli (n = 301, 77.8 %), S. saprophyticus (n = 20, 5.2 %), Klebsiella pneumoniae (n = 13, 3.4 %), and Enterococcus faecalis (n = 11, 2.8 %). S. saprophyticus was significantly more common in premenopausal women (P = 0.00095). The minimum inhibitory concentrations of 19 antibacterial agents used for these strains were determined according to the Clinical and Laboratory Standards Institute manual. At least 87 % of E. coli isolates showed susceptibility to fluoroquinolones and cephalosporins, and 100 % of S. saprophyticus isolates showed susceptibility to fluoroquinolones and aminoglycosides. The proportions of fluoroquinolone-resistant E. coli strains and extended-spectrum β-lactamase (ESBL)-producing E. coli strains were 13.3 % and 4.7 %, respectively. It is important to confirm the susceptibility of causative bacteria for optimal antimicrobial therapy, and empiric antimicrobial agents should be selected by considering patient characteristics and other factors. However, the number of isolates of fluoroquinolone-resistant or ESBL-producing strains in gram-negative bacilli may be increasing in patients with urinary tract infections (UTIs) in Japan. Therefore, these data present important information for the proper treatment of UTIs and will serve as a useful reference for future surveillance studies.

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Conflict of interest

Akira Watanabe is a consultant to Daiichi-Sankyo, Mitsubishi Tanabe Pharma Corporation, Toyama Chemical, and Otsuka Pharmaceutical. A.W. has received a speaker’s honorarium from MSD Japan, Glaxo SmithKline K.K., Shionogi & Co. Ltd., Daiichi-Sankyo, Taisho Toyama Pharmaceutical, Dainippon Sumitomo Pharma, and Pfizer Japan Inc.; and grant support from Kyorin Pharmaceutical, Shionogi & Co. Ltd., Taisho Pharmaceutical, Toyama Chemical, Daiichi-Sankyo, Dainippon Sumitomo Pharma, Taiho Pharma, and Meiji Seika Pharma. Keisuke Sunakawa has research grant for other research than this study from Meiji Seika Pharma Co., Ltd.

Author information

Authors and Affiliations

  1. Urogenital sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JCS), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan

    Hiroshi Hayami, Satoshi Takahashi, Kiyohito Ishikawa, Mitsuru Yasuda, Shingo Yamamoto, Shinya Uehara, Ryoichi Hamasuna, Tetsuro Matsumoto, Shinichi Minamitani, Akira Watanabe, Aikichi Iwamoto, Kyoichi Totsuka, Junichi Kadota, Keisuke Sunakawa & Junko Sato

  2. The Kitasato Institute, Tokyo, Japan

    Hideaki Hanaki

  3. Blood Purification Center, Kagoshima University Hospital, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan

    Hiroshi Hayami

  4. Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan

    Satoshi Takahashi & Taiji Tsukamoto

  5. Department of Urology, The Jikei University School of Medicine, Tokyo, Japan

    Shin Egawa & Takahiro Kimura

  6. Department of Urology, The Jikei University Katsushika Medical Center, Tokyo, Japan

    Hiroshi Kiyota

  7. Department of Urology, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan

    Kiyohito Ishikawa

  8. Department of Urology, Graduate School of Medicine, Gifu University, Gifu, Japan

    Mitsuru Yasuda

  9. Division of Urology, Department of Surgery Related Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan

    Kazushi Tanaka, Soichi Arakawa & Masato Fujisawa

  10. Department of Urology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

    Shingo Yamamoto

  11. Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Shinya Uehara & Hiromi Kumon

  12. Department of Urology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan

    Kanao Kobayashi & Akio Matsubara

  13. Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan

    Ryoichi Hamasuna & Tetsuro Matsumoto

  14. Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Seiji Naito & Katsunori Tatsugami

  15. Yamaguchi Dermatology and Urology Clinic, Fukuoka, Japan

    Takamasa Yamaguchi

  16. iClinic, Sendai, Miyagi, Japan

    Shin Ito

  17. Kanokogi Clinic, Nishinomiya, Hyogo, Japan

    Mototsugu Kanokogi

  18. Narita Clinic, Nagoya, Aichi, Japan

    Harunori Narita

  19. Kawano Urologic and Dermatologic Clinic, Fukuoka, Japan

    Hiromi Kawano

  20. Hosobe Clinic, Tokyo, Japan

    Takahide Hosobe

  21. Department of Urology, Takayama Hospital, Fukuoka, Japan

    Kazuo Takayama

  22. Sumii Clinic, Hiroshima, Japan

    Toru Sumii

  23. Nippon Steel Hirohata Hospital, Kobe, Hyogo, Japan

    Akira Fujii

  24. Nissin Urological Clinic, Hokkaido, Japan

    Takashi Sato

  25. Yamauchi Urological Clinic, Nagoya, Aichi, Japan

    Takamine Yamauchi

  26. Izumitani Fureai Clinic, Nagoya, Aichi, Japan

    Masanobu Izumitani

  27. Chokyu Tenma Clinic, Kobe, Hyogo, Japan

    Hirofumi Chokyu

  28. Ihara Clinic, Kobe, Hyogo, Japan

    Hideari Ihara

  29. Akiyama Urology Clinic, Nishinomiya, Hyogo, Japan

    Kikuo Akiyama

  30. Yoshioka Urology Clinic, Nishinomiya, Hyogo, Japan

    Masaru Yoshioka

  31. Hirajima Clinic, Okayama, Japan

    Satoshi Uno

  32. Araki Urological Clinic, Okayama, Japan

    Koichi Monden

  33. Department of Urology, Kano Hospital, Fukuoka, Japan

    Motonori Kano

  34. Kaji Clinic, Fukuoka, Japan

    Shinichi Kaji

  35. Kawai Urology Clinic, Fukuoka, Japan

    Shuichi Kawai

  36. Ito Urology Clinic, Fukuoka, Japan

    Kenji Ito

  37. Munakata Suikokai General Hospital, Fukuoka, Japan

    Hisato Inatomi

  38. Nishimura Urology Clinic, Fukuoka, Japan

    Hirofumi Nishimura

  39. Uenoharu Clinic, Fukuoka, Japan

    Toshihiro Ikuyama

  40. Nishi Urology and Dermatology Clinic, Fukuoka, Japan

    Shohei Nishi

  41. Fukuoka Shin Mizumaki Hospital, Fukuoka, Japan

    Koichi Takahashi

  42. Izumi General Center, Kagoshima, Japan

    Yukihiro Kawano

  43. Kizawa Memorial Hospital, Gifu, Japan

    Satoshi Ishihara

  44. Ibusuki National Hospital, Kagoshima, Japan

    Kengo Tsuneyoshi

  45. Kagoshima Prefectural Ohshima Hospital, Kagoshima, Japan

    Shinji Matsushita

  46. Kimotsuki-gun Medical Associated Hospital, Kagoshima, Japan

    Takashi Yamane

  47. Hokkaido Social Insurance Hospital, Hokkaido, Japan

    Takaoki Hirose

  48. Department of Urology, Japanese Red Cross Gifu Hospital, Gifu, Japan

    Shigeru Fujihiro

  49. Department of Urology, JR Tokyo General Hospital, Tokyo, Japan

    Katsuhisa Endo

  50. Kakogawa City Hospital, Kakogawa, Hyogo, Japan

    Yasuhiko Oka

  51. Department of Urology, National Hospital Organization Hakodate National Hospital, Hokkaido, Japan

    Koh Takeyama

  52. Remmedi Kitakyushu Nephro Clinic, Fukuoka, Japan

    Tetsuji Uemura

Authors
  1. Hiroshi Hayami
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  2. Satoshi Takahashi
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  3. Kiyohito Ishikawa
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  4. Mitsuru Yasuda
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  5. Shingo Yamamoto
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  7. Ryoichi Hamasuna
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  9. Shinichi Minamitani
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  36. Akira Fujii
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  37. Takashi Sato
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  38. Takamine Yamauchi
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  39. Masanobu Izumitani
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  40. Hirofumi Chokyu
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  66. Tetsuji Uemura
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Corresponding author

Correspondence to Hiroshi Hayami.

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Hayami, H., Takahashi, S., Ishikawa, K. et al. Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus . J Infect Chemother 19, 393–403 (2013). https://doi.org/10.1007/s10156-013-0606-9

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  • DOI: https://doi.org/10.1007/s10156-013-0606-9

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