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Catechin protects against oxidative stress and inflammatory-mediated cardiotoxicity in adriamycin-treated rats

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Abstract

Catechin has anti-inflammatory and antioxidative effects. Cardiotoxicity, which results from intense cardiac oxidative stress and inflammation, is the main limiting factor of the adriamycin use in the treatment of malignant tumors. Thus, the present study aimed to assess the antioxidant and anti-inflammatory effects of catechin on adriamycin-induced cardiotoxicity in rats. Forty-five rats were allocated to three groups: control group, adriamycin group and adriamycin + catechin group. We performed the following measurements: lipid peroxidation (MDA), catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities as well as, the expression of inflammatory cytokines genes namely nuclear factor kappa-B, tumor necrosis factor and inducible nitric oxide synthase. Catechin administration significantly decreased MDA level and significantly increased CAT, GSH-Px and SOD activities. Also, catechin significantly decreased the expression levels of inflammatory cytokines. Catechin provided cardioprotection on adriamycin-induced cardiotoxicity through their antioxidant and anti-inflammatory properties.

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Authors and Affiliations

  1. Cardiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

    Tarek A. Abd El-Aziz

  2. Medical Biochemistry Department, Faculty of Medicine, Zagazig University, 28-El-Galaa Street, Zagazig, Egypt

    Randa H. Mohamed & Heba F. Pasha

  3. Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

    Hisham R. Abdel-Aziz

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  1. Tarek A. Abd El-Aziz
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  2. Randa H. Mohamed
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  4. Hisham R. Abdel-Aziz
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Correspondence to Randa H. Mohamed.

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Abd El-Aziz, T.A., Mohamed, R.H., Pasha, H.F. et al. Catechin protects against oxidative stress and inflammatory-mediated cardiotoxicity in adriamycin-treated rats. Clin Exp Med 12, 233–240 (2012). https://doi.org/10.1007/s10238-011-0165-2

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  • DOI: https://doi.org/10.1007/s10238-011-0165-2

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