Abstract
Biomanufacturing is a type of manufacturing that utilizes biological systems (e.g., living microorganisms, resting cells, animal cells, plant cells, tissues, enzymes, or in vitro synthetic (enzymatic) systems) to produce commercially important biomolecules for use in the agricultural, food, material, energy, and pharmaceutical industries. History of biomanufacturing could be classified into the three revolutions in terms of respective product types (mainly), production platforms, and research technologies. Biomanufacturing 1.0 focuses on the production of primary metabolites (e.g., butanol, acetone, ethanol, citric acid) by using mono-culture fermentation; biomanufacturing 2.0 focuses on the production of secondary metabolites (e.g., penicillin, streptomycin) by using a dedicated mutant and aerobic submerged liquid fermentation; and biomanufacturing 3.0 focuses on the production of large-size biomolecules—proteins and enzymes (e.g., erythropoietin, insulin, growth hormone, amylase, DNA polymerase) by using recombinant DNA technology and advanced cell culture. Biomanufacturing 4.0 could focus on new products, for example, human tissues or cells made by regenerative medicine, artificial starch made by in vitro synthetic biosystems, isobutanol fermented by metabolic engineering, and synthetic biology-driven microorganisms, as well as exiting products produced by far better approaches. Biomanufacturing 4.0 would help address some of the most important challenges of humankind, such as food security, energy security and sustainability, water crisis, climate change, health issues, and conflict related to the energy, food, and water nexus.
Similar content being viewed by others
References
Afeyan NB, Cooney CL (2006) Professor Daniel I.C. Wang: a legacy of education, innovation, publication, and leadership. Biotechnol Bioeng 95(2):206–217
Atsumi S, Hanai T, Liao JC (2008) Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels. Nature 451(7174):86–89
Benner SA, Sismour AM (2005) Synthetic biology. Nat Rev Gen 6(7):533–543
Bornscheuer UT, Huisman GW, Kazlauskas RJ, Lutz S, Moore JC, Robins K (2012) Engineering the third wave of biocatalysis. Nature 485(7397):185–194
Chen H-G, Zhang Y-HP (2015) New biorefineries and sustainable agriculture: increased food, biofuels, and ecosystem security. Renew Sust Energy Rev 47:117–132
Davies HM (2010) Commercialization of whole-plant systems for biomanufacturing of protein products: evolution and prospects. Plant Biotechnol J 8(8):845–861
Demain AL (2004) Pickles, pectin, and penicillin. Annu Rev Microbiol 58:1–42
Demain AL (2007) REVIEWS: the business of biotechnology. Ind Biotechnol 3(3):269–283
Demain AL, Vaishnav P (2009) Production of recombinant proteins by microbes and higher organisms. Biotechnol Adv 27(3):297–306
Department of Economic and Social Affairs, United Nations (2013) World economic and social survey 2013—sustainable development challenges
Dudley QM, Karim AS, Jewett MC (2015) Cell-free metabolic engineering: biomanufacturing beyond the cell. Biotechnol J 10:69–82
Endy D (2005) Foundations for engineering biology. Nature 438(7067):449–453
Fessner W-D (2015) Systems Biocatalysis: development and engineering of cell-free “artificial metabolisms” for preparative multi-enzymatic synthesis. New Biotechnol 32:658–664
Fleet GH (2008) Wine yeasts for the future. FEMS Yeast Res 8(7):979–995
Forster AC, Church GM (2007) Synthetic biology projects in vitro. Genome Res 17(1):1–6
Galanie S, Thodey K, Trenchard IJ, Filsinger Interrante M, Smolke CD (2015) Complete biosynthesis of opioids in yeast. Science 349:1095–1100
Goerke AR, Loening AM, Gambhir SS, Swartz JR (2008) Cell-free metabolic engineering promotes high-level production of bioactive Gaussia princeps luciferase. Metab Eng 10(3–4):187–200
Goerke AR, Swartz JR (2008) Development of cell-free protein synthesis platforms for disulfide bonded proteins. Biotechnol Bioeng 99(2):351–367
Goto M, Akai K, Murakami A, Hashimoto C, Tsuda E, Ueda M, Kawanishi G, Takahashi N, Ishimoto A, Chiba H et al (1988) Production of recombinant human erythropoietin in mammalian cells: host-cell dependency of the biological activity of the cloned glycoprotein. Nat Biotechnol 6(1):67–71
Gottschalk U, Brorson K, Shukla AA (2012) The need for innovation in biomanufacturing. Nat Biotechnol 30(6):489–492
Guterl J-K, Garbe D, Carsten J, Steffler F, Sommer B, Reiße S, Philipp A, Haack M, Rühmann B, Kettling U et al (2012) Cell-free metabolic engineering—production of chemicals via minimized reaction cascades. ChemSusChem 5:2165–2172
Henry RJ (1943) The mode of action of sulfonamides. Bacteriol Rev 7(4):175–262
Hu Q-Y, Berti F, Adamo R (2016) Towards the next generation of biomedicines by site-selective conjugation. Chem Soc Rev 45:1691–1719
Humphrey AE (1991) Elmer L. Gaden, Jr., father of biochemical engineering. Biotechnol Bioeng 37(11):995–997
Jewett MC, Calhoun KA, Voloshin A, Wuu JJ, Swartz JR (2008) An integrated cell-free metabolic platform for protein production and synthetic biology. Mol Syst Biol 4:57
Kanter G, Yang J, Voloshin A, Levy S, Swartz JR, Levy R (2007) Cell-free production of scFv fusion proteins: an efficient approach for personalized lymphoma vaccines. Blood 109(8):3393–3399
Karim AS, Jewett MC (2016) A cell-free framework for rapid biosynthetic pathway prototyping and enzyme discovery. Metab Eng 36:116–126
Kim E-J, Adams M, Wu C-H, Zhang YHP (2016) Exceptionally high rates of biological hydrogen production by biomimetic in vitro synthetic enzymatic pathways. Chem A Eur J 22:16047–16051
Kim J-E, Zhang Y-HP (2016) Biosynthesis of d-xylulose 5-phosphate from d-xylose and polyphosphate through a minimized two-enzyme cascade. Biotechnol Bioeng 113:275–282
Korman TP, Sahachartsiri B, Li D, Vinokur JM, Eisenberg D, Bowie JU (2014) A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates. Protein Sci 25:576–585
Kwok R (2010) Five hard truths for synthetic biology. Nature 463:288–290
Lan EI, Liao JC (2013) Microbial synthesis of n-butanol, isobutanol, and other higher alcohols from diverse resources. Bioresour Technol 135:339–349
Lee SY (1996) High cell-density culture of Escherichia coli. Trends Biotechnol 14(3):98–105
Liese A, Hilterhaus L (2013) Evaluation of immobilized enzymes for industrial applications. Chem Soc Rev 42:6236–6249
Mason C, Dunnill P (2007) A brief definition of regenerative medicine. Regen Med 3(1):1–5
McGovern PE, Zhang J, Tang J, Zhang Z, Hall GR, Moreau RA, Nuñez A, Butrym ED, Richards MP, C-s Wang et al (2004) Fermented beverages of pre- and proto-historic China. Proc Nat Acad Sci USA 101(51):17593–17598
Michels P, Rosazza J (2009) The evolution of microbial transformations for industrial applications. SIM News 2009(March/April):36–52
Moustafa HMA, Kim E-J, Zhu Z, Wu C-H, Zaghloul TI, Adams MWW, Zhang YHP (2016) Water splitting for high-yield hydrogen production energized by biomass xylooligosaccharides catalyzed by an enzyme cocktail. ChemCatChem. doi:10.1002/cctc.201600772
Myung S, Rollin J, You C, Sun F, Chandrayan S, Adams MWW, Zhang Y-HP (2014) In vitro metabolic engineering of hydrogen production at theoretical yield from sucrose. Metab Eng 24(1):70–77
Myung S, Zhang X-Z, Zhang Y-HP (2011) Ultra-stable phosphoglucose isomerase through immobilization of cellulose-binding module-tagged thermophilic enzyme on low-cost high-capacity cellulosic adsorbent. Biotechnol Prog 27:969–975
Opgenorth PH, Korman TP, Bowie JU (2014) A synthetic biochemistry molecular purge valve module that maintains redox balance. Nat Commun 5:4113
Opgenorth PH, Korman TP, Bowie JU (2016) A synthetic biochemistry module for production of bio-based chemicals from glucose. Nat Chem Biol 12:393–395
Paddon CJ, Keasling JD (2014) Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development. Nat Rev Microbiol 12(5):355–367
Qi P, You C, Zhang YHP (2014) One-pot enzymatic conversion of sucrose to synthetic amylose by using enzyme cascades. ACS Catal 4:1311–1317
Renata H, Wang ZJ, Arnold FH (2015) Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution. Angew Chem Int Ed 54(11):3351–3367
Rieckenberg F, Ardao I, Rujananon R, Zeng A-P (2014) Cell-free synthesis of 1,3-propanediol from glycerol with a high yield. Eng Life Sci 14:380–386
Ro D-K, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J et al (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440(7086):940–943
Rollin JA, Martin del Campo J, Myung S, Sun F, You C, Bakovic A, Castro R, Chandrayan SK, Wu C-H, Adams MWW et al (2015) High-yield hydrogen production from biomass by in vitro metabolic engineering: mixed sugars coutilization and kinetic modeling. Proc Nat Acad Sci USA 112:4964–4969
Sakai H, Nakagawa T, Tokita Y, Hatazawa T, Ikeda T, Tsujimura S, Kano K (2009) A high-power glucose/oxygen biofuel cell operating under quiescent conditions. Energy Environ Sci 2:133–138
Sano C (2009) History of glutamate production. Am J Clin Nutr 90(3):728S–732S
Satoh Y, Tajima K, Tannai H, Munekata M (2003) Enzyme-catalyzed poly(3-hydroxybutyrate) synthesis from acetate with CoA recycling and NADPH regeneration in vitro. J Biosci Bioeng 95(4):335–341
Sattler JH, Fuchs M, Mutti FG, Grischek B, Engel P, Pfeffer J, Woodley JM, Kroutil W (2014) Introducing an In Situ Capping Strategy in Systems Biocatalysis To Access 6-Aminohexanoic acid. Angew Chem Int Ed n/a–n/a
Schwab K (2016) The fourth industrial revolution. World Economic Forum, Geneva
Sheldon RA, van Pelt S (2013) Enzyme immobilisation in biocatalysis: why, what and how. Chem Soc Rev 42(15):6223–6235
Siegel JB, Smith AL, Poust S, Wargacki AJ, Bar-Even A, Louw C, Shen BW, Eiben CB, Tran HM, Noor E et al (2015) Computational protein design enables a novel one-carbon assimilation pathway. Proc Nat Acad Sci USA 112(12):3704–3709
Siegfried T (2005) In praise of hard questions. Science 309(5731):76–77
Sochaj AM, Świderska KW, Otlewski J (2015) Current methods for the synthesis of homogeneous antibody–drug conjugates. Biotechnol Adv 33(6, Part 1):775–784
Stephanopoulos G (2012) Synthetic biology and metabolic engineering. ACS Synth Biol 1:514–525
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5):861–872
Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663–676
Tessaro D, Pollegioni L, Piubelli L, D’Arrigo P, Servi S (2015) Systems biocatalysis: an artificial metabolism for interconversion of functional groups. ACS Catal 5:1604–1608
Vasic-Racki D (2006) History of industrial biotransformations—dreams and realities. In: Liese A, Seebald S, Wandrey C (eds) Industrial biotransformations. Wiley-VCH,KGaA, Weinheim, pp 1–37
Wang Y, Huang W, Sathitsuksanoh N, Zhu Z, Zhang Y-HP (2011) Biohydrogenation from biomass sugar mediated by in vitro synthetic enzymatic pathways. Chem Biol 18:372–380
Wang Y, Zhang Y-HP (2009) Cell-free protein synthesis energized by slowly-metabolized maltodextrin. BMC Biotechnol 9:58
Ye X, Honda K, Sakai T, Okano K, Omasa T, Hirota R, Kuroda A, Ohtake H (2012) Synthetic metabolic engineering-a novel, simple technology for designing a chimeric metabolic pathway. Microb Cell Fact 11(1):120
Ye X, Zhang C, Zhang Y-HP (2012) Engineering a large protein by combined rational and random approaches: stabilizing the Clostridium thermocellum cellobiose phosphorylase. Mol BioSyst 8:1815–1823
You C, Chen H, Myung S, Sathitsuksanoh N, Ma H, Zhang X-Z, Li J, Zhang Y-HP (2013) Enzymatic transformation of nonfood biomass to starch. Proc Nat Acad Sci USA 110:7182–7187
Zhang Y-HP (2010) Production of biocommodities and bioelectricity by cell-free synthetic enzymatic pathway biotransformations: challenges and opportunities. Biotechnol Bioeng 105:663–677
Zhang Y-HP (2011) Simpler is better: high-yield and potential low-cost biofuels production through cell-free synthetic pathway biotransformation (SyPaB). ACS Catal 1:998–1009
Zhang Y-HP (2013) Next generation biorefineries will solve the food, biofuels, and environmental trilemma in the energy-food-water nexus. Energy Sci Eng 1:27–41
Zhang Y-HP (2015) Production of biofuels and biochemicals by in vitro synthetic biosystems: opportunities and challenges. Biotechnol Adv 33:1467–1483
Zhang Y-HP, Evans BR, Mielenz JR, Hopkins RC, Adams MWW (2007) High-yield hydrogen production from starch and water by a synthetic enzymatic pathway. PLoS One 2(5):e456
Zhang Y-HP, Himmel M, Mielenz JR (2006) Outlook for cellulase improvement: screening and selection strategies. Biotechnol Adv 24(5):452–481
Zhang Y-HP, Huang W-D (2012) Constructing the electricity-carbohydrate-hydrogen cycle for a sustainability revolution. Trends Biotechnol 30(6):301–306
Zhang Y-HP, Sun J-B, Zhong J-J (2010) Biofuel production by in vitro synthetic pathway transformation. Curr Opin Biotechnol 21:663–669
Zhou W, You C, Ma H, Ma Y, Zhang Y-HP (2016) One-pot biosynthesis of high-concentration α-glucose 1-phosphate from starch by sequential addition of three hyperthermophilic enzymes. J Agric Food Chem 64:1777–1783
Zhu Z-G, Kin Tam T, Sun F, You C, Zhang Y-HP (2014) A high-energy-density sugar biobattery based on a synthetic enzymatic pathway. Nat Commun 5:3026
Acknowledgements
This paper could not have been written without the support of the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, China and the Biological System Engineering Department, Virginia Polytechnic Institute and State University, Virginia, USA. Also, it is partially supported by the Department of Energy, Office of Energy Efficiency and Renewable Energy, Fuel Cell Technologies Office under Award Number DE-EE0006968 to YPZ. Also, authors JBS and YHM were partially supported by Tianjin Municipal Science and Technology Commission for the financial supports of 13ZCZDSY04900 and 11ZCZDSY08400. Funding to YPZ for this work was partially supported by the Virginia Agricultural Experiment Station and the Hatch Program of the National Institute of Food and Agriculture, U.S. Department of Agriculture.
Author information
Authors and Affiliations
Corresponding authors
Additional information
Tribute to Arny Demain, Industrial Microbiologist Extraordinaire Celebration of the 90th birthday of Arnold Demain.
Rights and permissions
About this article
Cite this article
Zhang, YH.P., Sun, J. & Ma, Y. Biomanufacturing: history and perspective. J Ind Microbiol Biotechnol 44, 773–784 (2017). https://doi.org/10.1007/s10295-016-1863-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10295-016-1863-2