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Temporal registration: a new approach to manage the incomplete recovery of the longitudinal magnetization in the Modified Look-Locker Inversion Recovery sequence (MOLLI) for T1 mapping of the heart

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Abstract

Purpose

To correct with post-processing effects of incomplete recovery of the longitudinal magnetization before a new inversion pulse in the Modified Look-Locker Inversion recovery sequence (MOLLI) sequence.

Theory and methods

We model such effects as a temporal shift (\(\tau\)) of the signal of the Look-Locker block following next inversion pulses. After using the following equation \(S\left( t \right) = A - B \times \exp \left( { - \left( {t + \tau } \right)/T1^{*} } \right)\), a temporal registration of \(\tau\) is applied to the signal of the affected block to adjust the sampling time of the recovery signal and correct the underlying effect on quantitative T1. To test our approach, simulations, phantoms, and five volunteers’ data were used while applying different MOLLI sampling schemes at different heart rates and compared to the reference three-parameter fit.

Results

The temporal registration of the affected signals allows to reach higher accuracy on long T1 when compared to the reference three parameters fit (10.15 vs 22.12% for T1 = 1785 ms; 8.22 vs 14.65% for T1 = 1278 ms), and lower average variation in case of rest-period deletion (62 vs 231 ms).

Conclusion

The proposed approach leads to more accurate T1 in case of incomplete recovery. It is less sensitive to parameters affecting the recovery such as the rest period or the sampling scheme; and, therefore, supports multi-center studies with different MOLLI protocols.

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Author information

Authors and Affiliations

  1. GE Healthcare, Advantage Workstation, Buc, France

    Habib Rebbah & Thierry Galas

  2. Paris Cardiovascular Research Center (PARCC), INSERM/HEGP, Paris, France

    Habib Rebbah, Gilles Soulat, Charles A. Cuenod & Elie Mousseaux

  3. Hôpital Européen George Pompidou, Paris, France

    Gilles Soulat, Charles A. Cuenod & Elie Mousseaux

  4. Laboratoire D’Imagerie Biomédicale, INSERM, CNRS, Sorbonne Université, Paris, France

    Nadjia Kachenoura

  5. GE Research Center, Research Team, Munich, Germany

    Anne Menini

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  1. Habib Rebbah
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  4. Nadjia Kachenoura
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  5. Anne Menini
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  7. Elie Mousseaux
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Contributions

HR study conception and design, acquisition of data, analysis and interpretation of data, and drafting of manuscript. TG analysis and interpretation of data, and critical revision. GS acquisition of data, analysis, and interpretation of data. NK analysis and interpretation of data, and critical revision. AM study conception and design. CAC analysis and interpretation of data, and critical revision. EM acquisition of data, analysis and interpretation of data, and critical revision.

Corresponding author

Correspondence to Habib Rebbah.

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Conflict of interest

Rebbah, and Galas, and Menini are/were employees of GE Healthcare. Soulat declares that he has no conflict of interest. Kachenoura declares that she has no conflict of interest. Cuenod declares that he has no conflict of interest. Mousseaux declares that he has no conflict of interest.

Ethical approval

This article does not contain any studies with animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Rebbah, H., Galas, T., Soulat, G. et al. Temporal registration: a new approach to manage the incomplete recovery of the longitudinal magnetization in the Modified Look-Locker Inversion Recovery sequence (MOLLI) for T1 mapping of the heart. Magn Reson Mater Phy 33, 569–580 (2020). https://doi.org/10.1007/s10334-019-00815-6

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  • DOI: https://doi.org/10.1007/s10334-019-00815-6

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