Summary
Aloe arborescens (Candelabra Aloe) has been used in the treatment of upper respiratory tract infections in Central and Eastern European countries for many decades. Originally introduced to support the healing and recovery in cornea transplant patients, aqueous A. arborescens extracts soon became popular in the treatment of upper respiratory tract infections with a focus on toddlers and children. Recent preclinical and clinical data show that immunomodulatory, antiinflammatory, and antiviral effects contribute to its therapeutic efficacy. Based on its well documented, longstanding traditional use and its excellent safety and tolerability, A. arborescens may be considered a valuable addition to the spectrum of herbal medicinal products for the treatment and prophylaxis of upper respiratory tract infections, in particular common cold, in adults and children.
Zusammenfassung
Aloe arborescens, die Baumaloe, wird in Mittel- und Osteuropa seit vielen Jahrzehnten bei Erkrankungen der oberen Atemwege eingesetzt. Wurden Zubereitungen aus Baumaloe in den 1930er Jahren zunächst zur Unterstützung der Heilung und Rekonvaleszenz bei Cornea-Transplantationen eingesetzt, spielte schon bald ihre Anwendung bei Atemwegserkrankungen von Kleinkindern und Kindern eine wichtigere Rolle. Neuere präklinische und klinische Daten zeigen, dass immunmodulatorische, entzündungshemmende und antivirale Effekte zur Wirksamkeit von Aloe arborescens beitragen. Aufgrund ihrer jahrzehntelangen gut dokumentierten Anwendung und ihrer sehr guten Verträglichkeit können Zubereitungen aus Aloe arborescens eine wertvolle Ergänzung des Spektrums pflanzlicher Arzneimittel für die symptomatische Behandlung und Rezidivprophylaxe von Erkältungskrankheiten bei Erwachsenen und Kindern darstellen.
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Notes
At this stage, Bioaron C® did not contain Vitamin C, while in all other studies, it also contained Vitamin C.
References
Hager. Hagers Enzyklopädie der Arzneistoffe und Drogen, HagerROM. Berlin: Springer-Verlag; 2011.
Jambor J. Baumaloe (Aloe arborescens Mill.). In: Handbuch des Arznei- und Gewürzpflanzenanbaus, Band 4, Arznei- und Gewürzpflanzen A–K. Bernburg: Verein für Arznei- und Gewürzpflanzen SALUPLANTA e.V.; 2012. S. 219–28.
Gutterman Y, Chauser-Volfson E. The content of secondary phenol metabolites in pruned leaves of Aloe arborescens, a comparison between two methods: leaf exudates and leaf water extract. J Nat Med. 2008;62:430–5.
Hirata T, Suga T. Biologically active constituents of leaves and roots of Aloe arborescens var. natalensis. Z Naturforsch C. 1977;32(9–10):731–4.
Steenkamp L, Mathiba K, et al. Biocatalytic conversion of aloeresin A to aloesin. J Ind Microbiol Biotechnol. 2012;39(7):1091–7. doi:10.1007/s10295-012-1101-5.
Yagi A, Nishimura H, et al. Structure determination of polysaccharides in Aloe arborescens var. natalensis. Planta Med. 1986;52(3):213–8.
Mikołajczyk K, Wierzbicki A. Poznajemy zioła. Chemil Warszawa. 1989:str.16 i 20.
Alekseeva IV. Intranasal use of tincture of aloe in atrophic nasopharyngitis and ozena. Announc Otolaryngol. 1956;18(1):22–4.
Aryaew NL. Application experience of aloe tablets at acute pneumonia in children of first year of life. In: Tissue therapy. Odessa.1983. S. 7–8.
Müller-Dietz H, Rintelen K. Arzneipflanzen in der Sowjetunion, monograph Aloe arborescens Mill. In: Brandt M, editors. Berichte des Osteuropa-Institutes, Freie Universität Berlin, Medizinische Folge 18/1, Berlin. 1960.
Podgaeckiy GB. Experience of aloe in patients with tuberculosis of upper respiratory tract. The Ukrainian Central Tuberculosis research institute, Scientific materials, Kiev. 1941:83–5.
Puchugin PI. Treatment of tuberculosis in children with aloe. Memoires of the 3rd All-Union congress of children’s doctor, Leningrad. 1925;242–52.
Filatow WP. Optische Keratoplastik und Gewebetherapie. Berlin: VEB Verlag Volk und Gesundheit; 1954. S. 158–9, 189–90, 211, 216–7, 221–2, 239–51.
Ożarowski A. Herbs and Health (“Zioła a zdrowie”), Aloe plants in medicine (“Aloesy jako rośliny lecznicze”). Wiad Zielar. 1996;3:1–3.
Suzuki I, Saito H, et al. Purification and characterization of two lectins from Aloe arborescens Mill. J Biochem. 1979;85:163–71.
Imanishi K. Aloctin A, an active substance of Aloe arborescens Miller as an immunomodulator. Phytother Res. 1993;7(1):S20-S2.
Saito H. Purification of active substances of Aloe arborescens Miller and their biological and pharmacologial activity. Phytother Res. 1993;7(7):14–S9.
Appel. Report: Immunomodulatory effects of Bioaron C on inflammatory events in primary human immune cells. Part I (monocytes), Part II (T cells, macrophage cell lines) (unpublished study report): VivaCell Biotechnology GmbH, Freiburg 2003.
Białas-Chromiec B, Skopińska-Różewska E, et al. The immunomodulatory effect of Biostimine—water soluble extract of the leaves of triennial plants Aloe arborescens Mill. Onkol Pol. 2000;3:85–9.
Demkow U, Skopińska-Różewska E. The influence of herbal remedy BIOARON C on immunity. In: Skopińska-Różewska E, Siwicki AK, editors. Rola immunomodulatorów pochodzenia naturalnego w zapobieganiu i leczeniu chorób. Warszawa: MEDYK; 2003. S. 51–6.
Skopińska-Różewska E. Sprawozdanie z badań immunotropowej aktywności Bioaronu C (unpublished study report): Zakład Immunologii Instytutu Gruźlicy i Chorób Płuc, Warszawa 2000.
Marshal GD, Gibbons AS, Parnell LS. Human cytocines induced by acemannan. J Allergy Clin Immunol. 1993;91(1):295.
Pugh N, Ross SA, et al. Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity. J Agric Food Chem. 2001;49(2):1030–4.
Cichocki M, Michalak A, Appel K. Anti-inflammatory properties of Aloe arborescens and Aronia melanocarpa preparation BIOARON C®. 1st Polish-German Biochemical Societies Joint Meeting. Acta Bioch Pol Poznań. 2012(3):196.
Lehnfeld R, Appel K, et al. Anti-inflammatory activity of the herbal product Bioaron C®. 51 Annual Congress of the Society for Medicinal Plant Research. 2003. S. 217.
Speranza G, Morelli CF, et al. Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe. Planta Med. 2005;71(1):79–81.
CIR Expert Panel. Final Report on the Safety Assessment of Aloe Andongensis Extract, Aloe Andongensis Leaf Juice, Aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice, Aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract. Int J Toxicol. 2007;26(2):1–50.
Glatthaar-Saalmüller B, Michalak A, et al. Ocena aktywnosci przeciwwirusowej in vitro preparatów Biostymina i Bioaron C wzgledem ludzkiego rinowirusa (HRV14) – In vitro evaluation of antiviral activity of Biostymina and Bioaron C against human pathogenic virus: rhinovirus type 14 (HRV14). Postep Fitoter. 2012;3:156–61.
El Fiki NM, Shehata IA, et al. Biological study and phytochemical screening of several aloe species cultivated in Egypt. Planta Med. 2011;77(12):PL107.
Jia Y, Zhao G, Jia J. Preliminary evaluation: the effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing. J Ethnopharmacol. 2008;120(2):181–9.
Furowicz A, Czernomysy-Furowicz D, et al. Wykorzystanie Biostyminy w terapii i profilaktyce bronchopneumonii cieląt. Przegląd Hodowlany. 1989;9:10–2.
Bobkiewicz-Kozłowska T. Sprawozdanie z badań toksyczności preparatu Bioaron C: Katedra i Zakład Farmakologii AM w Poznaniu. 2001.
Matsuda Y, Yokohira M, et al. One-year chronic toxicity study of Aloe arborescens Miller var. natalensis Berger in Wistar Hannover rats. A pilot study. Food and chemical Toxicology. 2008;46(2):733–9. doi:10.1016/j.fct.2007.09.107.
Alkiewicz J. Sprawozdanie z badań nad tolerancją stosowania syropu Bioaron C u dzieci: Instytut Pediatrii A.M. w Poznaniu. 1988.
Horoszkiewicz-Hassan M, Beuscher N, et al. Tolerability and efficacy of Bioaron C® syrup in the treatment of upper respiratory tract infection in children. Results of a post-marketing surveillance study in Poland. Herba Polonica. 2005;51(1–2):45–53.
PhytoLab. Post Marketing Surveillance Study, Study Report. 2003/2004.
Pampura A. Kliniczna skuteczność, bezpieczeństwo, osobliwości odpornościowego działania przy profilaktycznym zastosowaniu preparatu Bioaron C u często chorujących dzieci: Rossdrav Rosja. 2006.
Ilina NI. Raport o testach klinicznych, tolerancji i klinicznej skuteczności preparatu Bioaron-C u dzieci, które cierpią na często powracające infekcje bakteryjne i wirusowe górnych dróg oddechowych: Instytut Immunologiczny, FMBA Rosja, Wydział Immunopatologii Dziecięcej Moskwa. 2006.
Aryayev N, Starikova A, OE. P. Otsenka klinicheskoy effektivnosti ispolzovaniya preparata Bioaron C v ambulatornom lechenii i profilaktike retsidiviruyushchikh – respiratornykh infektsiy u detey. Sov Pediatr. 2010;5:34.
Snegotskaya M, Konopelko O. Ob effektivnosti ispolzovaniya preparata Bioaron C® dlya profilaktiki i lecheniya ORZ. Prakt Pediatr. 2009:22–6.
Prokhorov E, Ostrovskiy I, et al. Effektivnost ispolzovaniya «Bioarona C» v lechenii ostrogo i retsidiviruyushchego bronhita u detey. Sov Pediatr. 2011;3:81–4.
Lokshina EE, Zaytseva OV. Novyye Podkhody V Terapii Retsidiviruyushchikh Respiratornykh Infektsiy U Detey. Sovrem Pediatr. 2010;4:32.
Tsodikova O, Harbar K, Barchan H. Kliniko-imunolohichni osoblyvosti homeostazu u ditey̆ z retsydyvnymy respiratornymy infektsiyamy ta ïkh dynamika pry vykorystanni Fitopreparatu «Bioaron C». Sov Pedyatr. 2011;5:117–21.
Conflict of interest
Financial support for studies reported in references no. 2, 18–21, 24, 25, 28, 31, 32, 34–41 and 43 was provided by Phytopharm Kleka S.A., Kleka, Poland. The sponsor had influence on the planning and conduct of the studies and provided the study medication/test substances. Jerzy Jambor and Anna Michalak and Natalia Walas-Marcinek are employees of Phytopharm Kleka and (co)-authors of some of the above mentioned publications.
Andrzej Fal has served as a consultant for Phytopharm Klęka S.A.
Petra Bastian, Britta Noster, Hartwig Sievers and Anke Steuber are employees of PhytoLab, which is a pharmaceutical contract laboratory for Phytopharm Kleka. They provided services on a contract basis related to several of the cited studies.
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Bastian, P., Fal, A., Jambor, J. et al. Candelabra Aloe (Aloe arborescens) in the therapy and prophylaxis of upper respiratory tract infections: traditional use and recent research results. Wien Med Wochenschr 163, 73–79 (2013). https://doi.org/10.1007/s10354-012-0171-3
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DOI: https://doi.org/10.1007/s10354-012-0171-3
Keywords
- Aloe arborescens
- Pediatric use
- Safety
- Traditional herbal medicinal product
- Upper respiratory tract infection