Abstract
Purpose
Vital dyes are frequently used to visualize the internal limiting membrane (ILM) of the neuroretina. This study evaluated and compared the microstructure of the inner retina and visual function with and without brilliant blue G (BBG) staining for ILM peeling during idiopathic epiretinal membrane (ERM) surgery.
Study design
Retrospective, consecutive, interventional case series.
Methods
Fifty-five patients (55 eyes) with ERM underwent ILM peeling without dyes (non-dye group) and 55 patients (55 eyes) underwent ILM peeling with BBG staining (BBG group). The logMAR visual acuity (VA) and ganglion cell complex (GCC) thickness were measured using optical coherence tomography at baseline and 12 months after surgery.
Results
LogMAR VA improved significantly in both groups at 12 months and the BBG group tended to be better than the non-dye group but with no significant difference between the groups (unpaired t-test, P = 0.490). The average GCC thickness significantly decreased in both groups; however, there was no difference in the rates of change in GCC thickness between the groups. The ratio of GCC thickness to total retinal thickness (%) was significantly higher in the BBG group in the superior quadrant at 12 months postoperatively (P = 0.010).
Conclusion
BBG-assisted ERM surgery resulted in better visual improvement and fewer structural changes in the inner retinal layers. BBG-assisted ILM peeling is safe both functionally and anatomically.
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Change history
23 July 2021
The original publication has been changed due to incorrect alignment of entries in Table 4
13 August 2021
A Correction to this paper has been published: https://doi.org/10.1007/s10384-021-00860-6
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Acknowledgements
The authors thank Mari S. Oba, Department of Medical Statistics Faculty of Medicine, Toho University, for her assistance with the statistical analysis. The authors thank the certified orthoptists Kazue Saito, Megumi Tamai, Moe Mita, and Kyoko Araki for their contribution to the spectral-domain optical coherence tomography image acquisition and data collection.
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A. Takeyama, None; Y. Imamura, None; M. Shibata, None; Y. Komiya, None; M. Ishida, None.
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Takeyama, A., Imamura, Y., Shibata, M. et al. Inner retinal structure and visual function after idiopathic epiretinal membrane surgery with and without brilliant blue G. Jpn J Ophthalmol 65, 689–697 (2021). https://doi.org/10.1007/s10384-021-00851-7
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DOI: https://doi.org/10.1007/s10384-021-00851-7