Abstract
Previous studies in the laboratory of the author have shown that subjecting flies to a mild stress (e.g. a cold stress) during the first 2 weeks of adult life can increase lifespan and resistance to severe stresses (e.g. heat and fungal infection) at 6 weeks of age (ca the mean lifespan at 25 °C). This result could either show that a mild stress protects flies against severe stress for the entire life or for a duration of 4 weeks. To clarify the issue, young flies living at 25 °C were pretreated with a cold stress and thereafter transferred at 19 or 22 °C, which increases lifespan. The mild cold stress protected these flies from heat at ages when flies kept at 25 °C are dead, i.e. at 10 weeks of age or 8 weeks after the end of cold stress. Thus, a mild stress protects flies for life, even if the duration of life is increased. Because temperature can strongly vary from day to day in the wild, and lifespan of flies too, it would be a selective advantage if the ability to survive a strong stress after having been subjected to a mild stress would be maintained not only for a few days but for life, whatever its duration could be. If flies would be subjected to a mild stress when living at 25 °C, a temperature change from e.g. 25 to 22 °C would increase their lifespan and they could survive a strong stress at an age when flies kept at 25 °C are dead.
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References
Chen HY, Maklakov AA (2012) Longer life span evolves under high rates of condition-dependent mortality. Curr Biol 22:2140–2143
David JR (1988) Temperature. In: Lints FA, Soliman MH (eds) Drosophila as a model organism for ageing studies. Blackie, Glasgow, pp 33–45
David J, Clavel MF (1969) Influence de la température sur le nombre, le pourcentage d’éclosion et la taille des œufs pondus par Drosophila melanogaster (Effect of temperature on number, hatching percentage, and size of laid eggs in Drosophila melanogaster). Ann Soc Ent Fr 5:161–177
Frolkis VV (1982) Aging and life-prolonging processes. Springer, Heidelberg
Khazaeli AA, Curtsinger JW (2013) Pleiotropy and life history evolution in Drosophila melanogaster: uncoupling life span and early fecundity. J Gerontol A 68:546–553
Kimber CM, Chippindale AK (2013) Mutation, condition, and the maintenance of extended lifespan in Drosophila. Curr Biol 23:2283–2287
Kirkwood TBL (2008) Understanding ageing from an evolutionary perspective. J Intern Med 263:117–127
Kjærsgaard A, Demontis D, Kristensen TN, Le N, Faurby S, Pertoldi C, Sørensen JG, Loeschcke V (2010) Locomotor activity of Drosophila melanogaster in high temperature environments: plastic and evolutionary responses. Clim Res 43:127–134
Kristensen TN, Sørensen JG, Loeschcke V (2003) Mild heat stress at a young age in Drosophila melanogaster leads to increased Hsp70 synthesis after stress exposure later in life. J Genet 82:89–94
Laukkanen T, Khan H, Zaccardi F, Laukkanen JA (2015) Association between sauna bathing and fatal cardiovascular and all-cause mortality events. JAMA Intern Med 175:542–548
Lavitrano M, Smolenski RT, Musumeci A, Maccherini M, Slominska E, Di Florio E, Bracco A, Mancini A, Stassi G, Patti M, Giovannoni R, Froio A, Simeone F, Forni M, Bacci ML, D’Alise G, Cozzi E, Otterbein LE, Yacoub MH, Bach FH, F Calise (2004) Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs. FASEB J 18:1093–1095
Le Bourg E (2007) Hormetic effects of repeated exposures to cold at young age on longevity. Biogerontology 8:431–444
Le Bourg E (2009) Hormesis, aging, and longevity. Biochim Biophys Acta 1790:1030–1039
Le Bourg E (2011) A cold stress applied at various ages can increase resistance to heat and fungal infection in aged Drosophila melanogaster flies. Biogerontology 12:185–193
Le Bourg E (2012) Combined effects of two mild stresses (cold and hypergravity) on longevity, behavioral aging, and resistance to severe stresses in Drosophila melanogaster. Biogerontology 13:313–328
Le Bourg E, Lints FA, Delincé J, Lints CV (1988) Reproductive fitness and longevity in Drosophila melanogaster. Exp Gerontol 23:491–500
Le Bourg E, Valenti P, Payre F (2002) Lack of hypergravity-associated longevity extension in Drosophila melanogaster flies overexpressing hsp70. Biogerontology 3:355–364
Le Bourg E, Malod K, Massou I (2012) The NF-κB-like factor DIF could explain some positive effects of a mild stress on longevity, behavioral aging, and resistance to strong stresses in Drosophila melanogaster. Biogerontology 13:455–465
Maklakov AA (2013) Aging: why do organisms live too long? Curr Biol 23:R1003–R1005
Maklakov AA (2015) Why organisms age: evolution of senescence under positive pleiotropy? BioEssays 37:802–807
Mattson MP, Calabrese EJ (eds) (2010) Hormesis. A revolution in biology, toxicology and medicine. Springer, Dordrecht
Medawar PB (1952) An unsolved problem in biology. HK Lewis, London
Miller MS, Lekkas P, Braddock JM, Farman GP, Ballif BA, Irving TC, Maughan DW, Vigoreaux JO (2008) Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila. Biophys J 95:2391–2401
Minois N, Le Bourg E (1999) Resistance to stress as a function of age in Drosophila melanogaster living in hypergravity. Mech Ageing Dev 109:53–64
Perrin S (2014) Preclinical research: make mouse studies work. Nature 507:423–425
Popper KR (1935) Logik der Forschung (the logic of scientific discovery). Verlag von Julius Springer, Vienna
Rattan SIS, Le Bourg E (eds) (2014) Hormesis in health and disease. CRC Press, Boca Raton
Reznick D, Bryant M, Holmes D (2006) The evolution of senescence and post-reproductive lifespan in guppies (Poecilia reticulata). PLoS Biol 4(1):e7
Sacher GA (1978) Evolution of longevity and survival characteristics in mammals. In: Schneider EL (ed) The genetics of aging. Plenum Press, New York, pp 151–168
Sarup P, Loeschcke V (2011) Life extension and the position of the hormetic zone depends on sex and genetic background in Drosophila melanogaster. Biogerontology 12:109117
Sørensen JG, Kristensen TN, Kristensen KV, Loeschcke V (2007) Sex specific effects of heat induced hormesis in Hsf- deficient Drosophila melanogaster. Exp Gerontol 42:1123–1129
Vaiserman AM (2011) Hormesis and epigenetics: is there a link? Ageing Res Rev 10:413–421
Vaiserman AM, Koshel NM, Litoshenko AY, Mozzhukhina TG, Voitenko VP (2003) Effect of X-irradiation in early ontogenesis on the longevity and amount of S1 nuclease- sensitive DNA sites in adult Drosophila melanogaster. Biogerontology 4:9–14
Williams GC (1957) Pleiotropy, natural selection and the evolution of senescence. Evolution 11:398–411
Wit J, Sarup P, Lupsa N, Malte H, Frydenberg J, Loeschcke V (2013) Longevity for free? Increased reproduction with limited trade-offs in Drosophila melanogaster selected for increased life span. Exp Geront 48:349–357
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Le Bourg, É. Life-time protection against severe heat stress by exposing young Drosophila melanogaster flies to a mild cold stress. Biogerontology 17, 409–415 (2016). https://doi.org/10.1007/s10522-015-9629-1
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DOI: https://doi.org/10.1007/s10522-015-9629-1