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Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases

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Abstract

Age is an important risk factor for different diseases. The same mechanisms that promote aging are involved in the development and progression of age-associated diseases. Polyphenols are organic compounds found in fruits and vegetables. Due to their beneficial properties (e.g. antioxidant and anti-inflammatory), polyphenols have been extensively used for treating chronic diseases. To exert their functions, polyphenols target various molecular mechanisms and signaling pathways, such as mTOR, NF-κB, and Wnt/β-catenin. Wnt signaling is a critical pathway for developmental processes. Besides, dysregulation of this signaling pathway has been observed in various diseases. Several investigations have been conducted on Wnt inhibitors at pre-clinical stages, showing promising results. Herein, we review the studies dealing with the role of polyphenols in targeting the Wnt signaling pathways in aging processes and age-associated diseases, including cancer, diabetes, Alzheimer’s disease, osteoporosis, and Parkinson’s disease.

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Abbreviations

PCP:

Planar cell polarity

GSK3β:

Glycogen synthase kinase 3β

CK1α:

Casein kinase 1α

APC:

Adenomatous polyposis coli

TRCP:

ββ-transducin repeat-containing protein

Lrp:

Low density lipoprotein receptor-related protein

Dvl:

Dishevelled

TCF:

T-cell factor

WRE:

Wnt response element

CBP:

Cyclic AMP response element-binding protein

SFRP5:

Secreted frizzled-related protein 5

NEAT1:

Nuclear enriched abundant transcript 1

lncRNA:

Long non-coding RNA

MALAT1:

Metastasis associated lung adenocarcinoma transcript 1

EGCG:

Epigallocatechin-3-gallate

PSC:

Pancreatic stem cell

TCF7L2:

Transcription factor 7-like 2 locus

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Authors and Affiliations

  1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran

    Parisa Maleki Dana, Fatemeh Sadoughi, Hamed Mirzaei & Zatollah Asemi

  2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

    Mohammad Ali Mansournia

  3. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran

    Bahman Yousefi

  4. Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran

    Bahman Yousefi

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  1. Parisa Maleki Dana
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  2. Fatemeh Sadoughi
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  3. Mohammad Ali Mansournia
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  4. Hamed Mirzaei
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PMD, FS, MAM, and HM contributed in conception, design and drafting of the manuscript. BY and ZA contributed in data collection and manuscript drafting. All authors approved the final version for submission.

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Maleki Dana, P., Sadoughi, F., Mansournia, M.A. et al. Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases. Biogerontology 22, 479–494 (2021). https://doi.org/10.1007/s10522-021-09934-x

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