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miR-212-5p Suppresses Glioma Development via Targeting SUMO2

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Abstract

Recently, increasing studies have suggested that miRNAs play a significant role in the occurrence and development of glioma. More researches are needed to explore the role of miRNAs in glioma, which will help to find new therapeutic targets. miR-212-5p has been reported to be involved in the progression in many cancers. However, whether miR-212-5p has a regulative effect on glioma remains un clear. In this study, we aimed to explore the effect of miR-212-5p on glioma development and its mechanism. Here, we demonstrated that miR-212-5p was lowly expressed in glioma cell. miR-212-5p suppressed the glioma cell proliferation, inhibited the migratory and invasive capabilities and promoted apoptosis in glioma cells. Besides, miR-212-5p also inhibited tumor growth in vivo. We found small ubiquitin-like modifier 2 (SUMO2) was the target of miR-212-5p, and miR-212-5p suppressed SUMO2 expression to regulate the proliferation, migration, and apoptosis of glioma cells. These findings indicated that miR-212-5p may be a possible therapeutic target for the treatment for glioma.

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All the data generated or analyzed during this study are included in this published article.

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Funding

This study was supported by Suqian Industrial Development Guide Fund Project (NO: K201902).

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Author notes

  1. Yulong Chong and Chunran Zhu have contributed equally to this work.

Authors and Affiliations

  1. Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210009, China

    Yulong Chong, Chengrong Jiang & Weibang Liang

  2. Suqian Hospital Affiliated to Xuzhou Medical University, 223800, Suqian, China

    Yulong Chong, Wei Hu & Zongjing Zhu

  3. Department of Neurosurgery, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing, 210028, China

    Chunran Zhu

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  1. Yulong Chong
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  2. Chunran Zhu
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  3. Wei Hu
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  4. Chengrong Jiang
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  5. Weibang Liang
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Correspondence to Weibang Liang or Zongjing Zhu.

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Chong, Y., Zhu, C., Hu, W. et al. miR-212-5p Suppresses Glioma Development via Targeting SUMO2. Biochem Genet 61, 35–47 (2023). https://doi.org/10.1007/s10528-022-10236-1

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  • DOI: https://doi.org/10.1007/s10528-022-10236-1

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