Abstract
In this work, we present a new iSIMPLE concept (infusion Self-powered Imbibing Microfluidic Pump by Liquid Encapsulation), which requires no external power for activation nor liquid manipulation, it is easy to use while its fabrication method is extremely simple, inexpensive and suited for mass replication. The pump consists of a working liquid, which is - after finger activation - absorbed in a porous material (e.g. filter paper). The air expelled from the porous material increases the pressure in the downstream outlet channel and propels the outlet liquid (i.e. the sample) through the channel or ejects it. Here we investigated the influence of different filter papers on the iSIMPLE flow rates, achieving a wide range from 30 down to 0.07 μL/min. We also demonstrated the versatility of the iSIMPLE in terms of the liquid volume that can be manipulated (from 0.5 μL up to 150 μL) and the working pressure reaching 64 kPa, unprecedented high for a self-powered microfluidics pump. In addition, using a 34 G microneedle mounted on the iSIMPLE, we successfully injected liquids with different viscosities (from 0.93 up to 55.88 cP) both into an agarose matrix and a skin-like biological ex vivo substrate (i.e. chicken breast tissue). This work validated the compatibility of the iSIMPLE with drug delivery in a controlled way into a skin-like matrix, envisioning a whole new scenario for intradermal injections using self-contained skin patch. In addition, due to the extreme flexibility of the design and manufacturing, the iSIMPLE concept offers enormous opportunities for completely autonomous, portable and cost effective LOC devices.
Similar content being viewed by others
References
J.B. Alarcon, A.W. Hartley, N.G. Harvey, J.A. Mikszta, Clin. Vaccine Immunol. 14, 375 (2007)
ALERE DETERMINE™ HIV-1/2 AG/AB COMBO (2016) https://www.alere.com/en/home/product-details/determine-1-2-ag-ab-combo.html?c=AU. Accessed 22 May 2018
P. Anton, Viscosity measurement of whole. Blood (2016)
A. Arora, I. Hakim, J. Baxter, R. Rathnasingham, R. Srinivasan, D.A. Fletcher, S. Mitragotri, Proc. Natl. Acad. Sci. U. S. A. 104, 4255 (2007)
S. Begolo, D.V. Zhukov, D.A. Selck, L. Li, R.F. Ismagilov, Lab Chip 14, 4616 (2014)
A.J. Chung, Y.S. Huh, D. Erickson, Biomed. Microdevices 11, 861 (2009)
Clearblue (2016) Clearblue pregnancy test. http://www.clearblue.com/healthcareprofessionals/pregnancy-tests. Accessed 22 May 2018
Clearview (2016) ALERE™ MALARIA AG P.F. https://www.alere.com/en/home/product-details/alere-malaria-ag-pf.html. Accessed 22 May 2018
G. Comina, A. Suska, D. Filippini, Biosens. Bioelectron. 77, 1153 (2015a)
G. Comina, A. Suska, D. Filippini, Angew. Chem. Int. Ed. Engl. 54, 8708 (2015b)
V.F. Curto, S. Coyle, R. Byrne, N. Angelov, D. Diamond, F. Benito-Lopez, Sensors Actuators B Chem. 175, 263 (2012a)
V.F. Curto, C. Fay, S. Coyle, R. Byrne, C.O.’. Toole, C. Barry, S. Hughes, N. Moyna, D. Diamond, F. Benito-Lopez, Sensors Actuators B Chem. 171, 1327 (2012b)
F. Dal Dosso, D. Decrop, E. Pérez-Ruiz, D. Daems, H. Agten, O. Al-Ghezi, O. Bollen, J. Breukers, F. De Rop, M. Katsafadou, J. Lepoudre, L. Lyu, P. Piron, R. Saesen, S. Sels, R. Soenen, E. Staljanssens, J. Taraporewalla, T. Kokalj, D. Spasic, J. Lammertyn, Anal. Chim. Acta (2017)
L.A. Dick, Innovative drug delivery technology to meet evolving need of biologics and small. Molecules (2015)
I.K. Dimov, L. Basabe-Desmonts, J.L. Garcia-Cordero, B.M. Ross, A.J. Ricco, L.P. Lee, Y. Park, A.J. Ricco, L.P. Lee, Lab Chip 11, 845 (2011)
E. Elizalde, R. Urteaga, C.L.A. Berli, Lab Chip 15, 2173 (2015)
J. Etter, C. Ng, A. Bohlke, S. Burton, and L. Dick, (n.d.)
C.P. Foley, N. Nishimura, K.B. Neeves, C.B. Schaffer, W.L. Olbricht, Biomed. Microdevices 11, 915 (2009)
E.L. França, E.B. Ribeiro, E.F. Scherer, D.G. Cantarini, R.S. Pessôa, F.L. França, A.C. Honorio-França, Biomed Res. Int 840379 (2014)
N. Fries, Capillary Transport Processes in Porous Materials: Experiment and Model, University of Bremen, (2010)
E. Fu, T. Liang, P. Spicar-Mihalic, J. Houghtaling, S. Ramachandran, P. Yager, Anal. Chem. 84, 4574 (2012)
H. Gensler, R. Sheybani, P.-Y. Li, R. Lo Mann, E. Meng, Biomed. Microdevices 14, 483 (2012)
L. Gervais, E. Delamarche, Lab Chip 9, 3330 (2009)
D. G. Greene, P. Wuthrich, R. C. Portilla, M. Herring, R. P. Mahoney, S. Webb, J. Sorvillo, and D. S. Soane, in 13th Annu. PEGS Summit (Boston, 2017)
W. Guo, J. Hansson, W. van der Wijngaart, Langmuir 32, 12650 (2016)
J. Gupta, S.S. Park, B. Bondy, E.I. Felner, M.R. Prausnitz, Biomaterials 32, 6823 (2011)
U.O. Häfeli, A. Mokhtari, D. Liepmann, B. Stoeber, Biomed. Microdevices 11, 943 (2009)
K. Hosokawa, K. Sato, N. Ichikawa, M. Maeda, Lab Chip 4, 181 (2004)
Inkscape (2016) https://inkscape.org/en/about/overview/. Accessed 22 May 2018
B.A. Inman, W. Etienne, R. Rubin, R.A. Owusu, T.R. Oliveira, D.B. Rodriques, P.F. Maccarini, P.R. Stauffer, A. Mashal, M.W. Dewhirst, Int. J. Hyperth. 29, 206 (2013)
N. Inoue, E. Takai, T. Arakawa, K. Shiraki, Mol. Pharm. 11, 1889 (2014)
W.W. Koelmans, G. Krishnamoorthy, A. Heskamp, J. Wissink, S. Misra, N. Tas, Mech. Eng. Res. 3, 51 (2013)
T. Kokalj, Y. Park, M. Vencelj, M. Jenko, L.P. Lee, Lab Chip 14, 4329 (2014)
E. Leonard, in Subcutaneous and Intramuscular Injections. Administration of Medication via intradermal (2017)
Po-Ying Li, J. Shih, R. Lo, B. Adams, R. Agrawa, S. Saati, M. S. Humayun, Yu-Chong Tai, and E. Meng, in 2007 IEEE 20th Int. Conf. Micro Electro Mech. Syst. (IEEE, 2007), pp. 15–18
G. Li, Y. Luo, Q. Chen, L. Liao, J. Zhao, Biomicrofluidics 6, 14118 (2012)
D.Y. Liang, A.M. Tentori, I.K. Dimov, L.P. Lee, Biomicrofluidics 5, 24108 (2011)
R. Lo, P.-Y. Li, S. Saati, R.N. Agrawal, M.S. Humayun, E. Meng, Biomed. Microdevices 11, 959 (2009)
D. Mark, S. Haeberle, G. Roth, F. von Stetten, R. Zengerle, Chem. Soc. Rev. 39, 1153 (2010)
W. Martanto, J.S. Moore, O. Kashlan, R. Kamath, P.M. Wang, J.M. O’Neal, M.R. Prausnitz, Pharm. Res. 23, 104 (2006)
A.W. Martinez, S.T. Phillips, G.M. Whitesides, E. Carrilho, Anal. Chem. 82, 3 (2010)
N.-T. Nguyen, S.A.M. Shaegh, N. Kashaninejad, D.-T. Phan, Adv. Drug Deliv. Rev. 65, 1403 (2013)
A. Nisar, N. Afzulpurkar, B. Mahaisavariya, A. Tuantranont, Sensors Actuators B Chem. 130, 917 (2008)
P. Novo, V. Chu, J.P. Conde, Biosens. Bioelectron. 57, 284 (2014)
M. Ochoa, C. Mousoulis, B. Ziaie, Adv. Drug Deliv. Rev. 64, 1603 (2012)
K.W. Oh, C.H. Ahn, J. Micromech. Microeng. 16, 13 (2006)
S.-J. Paik, S. Byun, J.-M. Lim, Y. Park, A. Lee, S. Chung, J. Chang, K. Chun, Sensors Actuators A 114, 276 (2004)
S.L. Perry, J.J.L. Higdon, P.J.A. Kenis, Lab Chip 10, 3112 (2010)
F.N. Pirmoradi, J.K. Jackson, H.M. Burt, M. Chiao, Lab Chip 11, 3072 (2011)
L. Qin, O. Vermesh, Q. Shi, J.R. Heath, Lab Chip 9 (2016, 2009)
X. Qiu, J.A. Thompson, Z. Chen, C. Liu, D. Chen, S. Ramprasad, M.G. Mauk, S. Ongagna, C. Barber, W.R. Abrams, D. Malamud, P.L.A.M. Corstjens, H.H. Bau, Biomed. Microdevices 11, 1175 (2009)
Quidel (2016) QuickVue Influenza A+B. https://www.quidel.com/immunoassays/rapid-influenza-tests/quickvue-influenza-test. Accessed 22 May 2018
R. Riahi, A. Tamayol, S.A.M. Shaegh, A.M. Ghaemmaghami, M.R. Dokmeci, A. Khademhosseini, Curr. Opin. Chem. Eng. 7, 101 (2015)
P. Ruef, J. Gehm, L. Gehm, C. Felbinger, J. Pöschl, N. Kuss, Gen. Physiol. Biophys. 33, 285 (2014)
R.K. Sivamani, B. Stoeber, G.C. Wu, H. Zhai, D. Liepmann, H. Maibach, Skin Res. Technol. 11, 152 (2005)
X. Wang, J.A. Hagen, I. Papautsky, Biomicrofluidics 7, 14107 (2013)
S.P. Woods, T.G. Constandinou, J. Micro-Bio Robot. 11, 19 (2016)
S. Yadav, S.J. Shire, D.S. Kalonia, J. Pharm. Sci. 99, 4812 (2010)
W. Yang, Y.G. Nam, B.-K. Lee, K. Han, T.H. Kwon, D.S. Kim, Jpn. J. Appl. Phys. 49, 06GM01 (2010)
E.-C. Yeh, C.-C. Fu, L. Hu, R. Thakur, J. Feng, L.P. Lee, Sci. Adv. 3, e1501645 (2017)
P.K. Yuen, V.N. Goral, Lab Chip 10, 384 (2010)
D. Zhang, D.B. Das, C.D. Rielly, J. Pharm. Sci. 103, 613 (2014)
M. Zimmermann, H. Schmid, P. Hunziker, E. Delamarche, Lab Chip 7, 119 (2007)
Acknowledgments
The research leading to these results has received funding from the Research Foundation - Flanders (FWO G086114 N), and the KU Leuven (OT 13/058, C3 project C32/17/007, C2 project C24/16/022).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Dal Dosso, F., Kokalj, T., Belotserkovsky, J. et al. Self-powered infusion microfluidic pump for ex vivo drug delivery. Biomed Microdevices 20, 44 (2018). https://doi.org/10.1007/s10544-018-0289-1
Published:
DOI: https://doi.org/10.1007/s10544-018-0289-1