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Risk factors for breast cancer from benign breast disease in a diverse population

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Abstract

Background The majority of studies have reported risks of breast cancer (BC) from benign breast disease (BBD) in essentially homogenous Caucasian populations. Information on breast cancer risk factors in larger, multi-ethnic populations should facilitate the development of appropriate and targeted risk reduction strategies. Design Cases and controls were drawn from a parent BBD cohort of 4,970 women, 1,341 African–Americans (AA) and 3,629 non-AA who were diagnosed with BBD after examination of an excisional breast biopsy. Risk factors (34 variables) included demographics, lesion types, and epidemiological variables. Results The final multivariable model retained significance (P < 0.05) for lesion risk-level, fibroadenoma, and the interaction of age-by-race. Women with proliferative lesions (no atypia, risk level 2) were 1.7 times more likely to develop BC when compared with women with non-proliferative lesions (OR = 1.7, 95% CI 1.13, 2.42, P = 0.009). Women with atypia (risk level 3) were 3.75 times more likely to develop BC compared to women with non-proliferative lesions (OR = 3.75, 95% CI 1.99, 7.06, P < 0.001). The odds of breast cancer was approximately 35% lower among women with fibroadenoma as compared to women without fibroadenoma (OR = 0.65, 95% CI 0.46, 0.94, P = 0.020). AA women with BBD who were 50 years or older were 2.28 times more likely to develop breast cancer as compared to non-AA women who were less than 50 years old (OR = 2.28, 95% CI 1.34, 3.88, P = 0.002). Conclusion Women with fibroadenoma (nonproliferative or proliferative) were less likely to progress to BC. Older AA women are at greater risk for progression to breast cancer from BBD.

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Acknowledgments

This research was supported by NIH CA 70923 (MJW) and ACS EDT-116 (MJW).

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Authors and Affiliations

  1. Department of Otolaryngology/Head and Neck Surgery, Henry Ford Health System, 1 Ford Place, 1D, Detroit, MI, 48202, USA

    Maria J. Worsham & Alyssa Botttrell

  2. Department of Pathology, Henry Ford Health System, Detroit, MI, 48202, USA

    Usha Raju

  3. Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI, 48202, USA

    Mei Lu & Alissa Kapke

  4. Wayne State University, Detroit, MI, USA

    Alyssa Botttrell

  5. Department of Head and Neck Surgery, Wayne State School of Medicine, Henry Ford Health System, 1 Ford Place, 1D, Detroit, MI, 48202, USA

    Jingfang Cheng

  6. Royal Gwent Hospital, South Wales, UK

    Varsha Shah

  7. LabMD, Inc., Atlanta, GA, USA

    Adnan Savera

  8. Department of Pathology, George Washington University, Washington, DC, 20052, USA

    Sandra R. Wolman

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  1. Maria J. Worsham
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Correspondence to Maria J. Worsham.

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Worsham, M.J., Raju, U., Lu, M. et al. Risk factors for breast cancer from benign breast disease in a diverse population. Breast Cancer Res Treat 118, 1–7 (2009). https://doi.org/10.1007/s10549-008-0198-8

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