Abstract
Breast cancer is the most prevalent type of cancer in American women. Exercise appears to diminish many of the side effects resulting from breast cancer and its treatment. Very little research, however, has compared the outcomes of varying lengths of combined aerobic and resistance training exercise interventions on physiological and psychological parameters in breast cancer survivors. The purpose of this study was to compare the physiological and psychological outcomes following 3 and 6 months of exercise in breast cancer survivors. Breast cancer survivors (N = 114) participated in either 3 months of prescriptive, individualized exercise (3M; n = 29), 6 months of prescriptive, individualized exercise (6M; n = 68), or served as sedentary controls (C; n = 17). Cancer survivors completed a medical evaluation and assessment at baseline followed by a predetermined 3- or 6-month exercise intervention. Cancer survivors in the control group performed no exercise between the initial assessment and 6-month reassessment. Cardiovascular endurance, pulmonary function, muscular endurance, fatigue, and symptoms of depression were assessed at baseline and post intervention. Repeated measures ANCOVA revealed improvements (P < 0.05) in cardiovascular endurance, fatigue, and symptoms of depression in breast cancer survivors undergoing 3- and 6-month individualized exercise interventions. Breast cancer survivors exercising for 6 months showed additional improvements (P < 0.05) in pulmonary function and muscular endurance. Cancer survivors in the control group did not improve in cardiovascular endurance, pulmonary function, muscular endurance, or fatigue. Three months of individualized, prescriptive exercise leads to improved cardiovascular endurance, fatigue, and symptoms of depression in breast cancer survivors. Additional benefits are seen if exercise is continued for a total of 6 months.
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References
American Cancer Society (2009) Cancer facts and figures. American Cancer Society, Atlanta
DeVita VT, Hellman S, Rosenberg SA (2005) Cancer, principles & practice of oncology, 7th edn. Lippincott Williams & Wilkins, Philadelphia, Ixxv, 2898 pp
Hayes S, Battistutta D, Newman B (2005) Objective and subjective upper body function six months following diagnosis of breast cancer. Breast Cancer Res Treat 94(1):1–10
Westrup JL et al (2006) Risk of decline in upper-body function and symptoms among older breast cancer patients. J Gen Intern Med 21(4):327–333
Albert US et al (2006) Early self-reported impairments in arm functioning of primary breast cancer patients predict late side effects of axillary lymph node dissection: results from a population-based cohort study. Breast Cancer Res Treat 100(3):285–292
Blomqvist L et al (2004) Evaluation of arm and shoulder mobility and strength after modified radical mastectomy and radiotherapy. Acta Oncol 43(3):280–283
Box RC et al (2002) Shoulder movement after breast cancer surgery: results of a randomised controlled study of postoperative physiotherapy. Breast Cancer Res Treat 75(1):35–50
Shamley DR et al (2007) Changes in shoulder muscle size and activity following treatment for breast cancer. Breast Cancer Res Treat 106(1):19–27
Leidenius M et al (2005) The consequences of long-time arm morbidity in node-negative breast cancer patients with sentinel node biopsy or axillary clearance. J Surg Oncol 92(1):23–31
Pyszel A et al (2006) Disability, psychological distress and quality of life in breast cancer survivors with arm lymphedema. Lymphology 39(4):185–192
Dow KH (2004) Contemporary issues in breast cancer: a nursing perspective, 2nd ed. Jones and Bartlett series in oncology. Jones and Bartlett, Sudbury, xvi, 349 pp
Nygren P (2001) What is cancer chemotherapy? Acta Oncol 40:166–174
Doyle JJ et al (2005) Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study. J Clin Oncol 23(34):8597–8605
Meinardi MT et al (2002) Evaluation of long term cardiotoxicity after epirubicin containing adjuvant chemotherapy and locoregional radiotherapy for breast cancer using various detection techniques. Heart 88(1):81–82
Erselcan T et al (2000) Subclinical cardiotoxicity following adjuvant dose-escalated FEC, high-dose chemotherapy, or CMF in breast cancer. Br J Cancer 82(4):777–781
de Graaf H et al (1997) Cardiotoxicity from intensive chemotherapy combined with radiotherapy in breast cancer. Br J Cancer 76(7):943–945
Wilczynski SW et al (1998) Delayed pulmonary toxicity syndrome following high-dose chemotherapy and bone marrow transplantation for breast cancer. Am J Respir Crit Care Med 157(2):565–573
Chap L et al (1997) Pulmonary toxicity of high-dose chemotherapy for breast cancer: a non-invasive approach to diagnosis and treatment. Bone Marrow Transplant 20(12):1063–1067
Hurria A et al (2006) A prospective, longitudinal study of the functional status and quality of life of older patients with breast cancer receiving adjuvant chemotherapy. J Am Geriatr Soc 54(7):1119–1124
Moon YW et al (2005) Neoadjuvant chemotherapy with infusional 5-fluorouracil, adriamycin and cyclophosphamide (iFAC) in locally advanced breast cancer: an early response predicts good prognosis. Ann Oncol 16(11):1778–1785
Erman M et al (2005) A phase II study on the safety and efficacy of 5-fluorouracil, epirubicin, cyclophosphamide (FEC) followed by paclitaxel in the adjuvant treatment of breast cancer. Cancer Investig 23(3):215–221
Vassilomanolakis M et al (2005) First-line chemotherapy with docetaxel and cisplatin in metastatic breast cancer. Breast 14(2):136–141
Hofman M et al (2007) Cancer-related fatigue: the scale of the problem. Oncologist 12(Suppl 1):4–10
Meeske K et al (2007) Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report. Qual Life Res 16(6):947–960
Servaes P et al (2007) The course of severe fatigue in disease-free breast cancer patients: a longitudinal study. Psychooncology 16(9):787–795
Bower JE et al (2006) Fatigue in long-term breast carcinoma survivors: a longitudinal investigation. Cancer 106(4):751–758
Bower JE et al (2000) Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life. J Clin Oncol 18(4):743–753
Burgess C et al (2005) Depression and anxiety in women with early breast cancer: five year observational cohort study. BMJ 330(7493):702
Hjerl K et al (2003) Depression as a prognostic factor for breast cancer mortality. Psychosomatics 44(1):24–30
Schneider CM et al (2007) Cancer treatment-induced alterations in muscular fitness and quality of life: the role of exercise training. Ann Oncol 18(12):1957–1962
Schneider CM et al (2007) Exercise training manages cardiopulmonary function and fatigue during and following cancer treatment in male cancer survivors. Integr Cancer Ther 6(3):235–241
Valenti M et al (2008) Physical exercise and quality of life in breast cancer survivors. Int J Med Sci 5(1):24–28
Carlson LE et al (2006) Individualized exercise program for the treatment of severe fatigue in patients after allogeneic hematopoietic stem-cell transplant: a pilot study. Bone Marrow Transplant 37(10):945–954
Adamsen L et al (2006) The effect of a multidimensional exercise intervention on physical capacity, well-being and quality of life in cancer patients undergoing chemotherapy. Support Care Cancer 14(2):116–127
Windsor PM, Nicol KF, Potter J (2004) A randomized controlled trial of aerobic exercise for treatment-related fatigue in men receiving radical external beam radiotherapy for localized prostate carcinoma. Cancer 101(3):550–557
Burnham TR, Wilcox A (2002) Effects of exercise on physiological and psychological variables in cancer survivors. Med Sci Sports Exerc 34(12):1863–1867
Mock V et al (2001) Fatigue and quality of life outcomes of exercise during cancer treatment. Cancer Pract 9(3):119–127
Schneider CM et al (2007) Effects of supervised exercise training on cardiopulmonary function and fatigue in breast cancer survivors during and after treatment. Cancer 110(4):918–925
Kim CJ et al (2006) Cardiopulmonary responses and adherence to exercise in women newly diagnosed with breast cancer undergoing adjuvant therapy. Cancer Nurs 29(2):156–165
Battaglini C et al (2007) The effects of an individualized exercise intervention on body composition in breast cancer patients undergoing treatment. Sao Paulo Med J 125(1):22–28
Courneya KS et al (2007) Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. J Clin Oncol 25(28):4396–4404
Schwartz AL, Winters-Stone K, Gallucci B (2007) Exercise effects on bone mineral density in women with breast cancer receiving adjuvant chemotherapy. Oncol Nurs Forum 34(3):627–633
Schwartz AL et al (2001) Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med Sci Sports Exerc 33(5):718–723
Schwartz AL (2000) Daily fatigue patterns and effect of exercise in women with breast cancer. Cancer Pract 8(1):16–24
Milne HM et al (2008) Effects of a combined aerobic and resistance exercise program in breast cancer survivors: a randomized controlled trial. Breast Cancer Res Treat 108(2):279–288
Cheema BS, Gaul CA (2006) Full-body exercise training improves fitness and quality of life in survivors of breast cancer. J Strength Cond Res 20(1):14–21
Sprod LK et al (2005) The effects of walking poles on shoulder function in breast cancer survivors. Integr Cancer Ther 4(4):287–293
Daley AJ et al (2007) Randomized trial of exercise therapy in women treated for breast cancer. J Clin Oncol 25(13):1713–1721
Holmes MD et al (2005) Physical activity and survival after breast cancer diagnosis. JAMA 293(20):2479–2486
Herrero F et al (2006) Combined aerobic and resistance training in breast cancer survivors: A randomized, controlled pilot trial. Int J Sports Med 27(7):573–580
Dwyer GB, Davis SE (eds) (2005) ACSM’s health-related physical fitness assessment manual. Lippincott Williams & Wilkins, Philadelphia, 180 pp
Schneider CM, Dennehy CA, Carter SD (2003) Exercise and cancer recovery. Human Kinetics, Champaign, xi, 219 pp
Piper BF et al (1998) The revised Piper Fatigue Scale: psychometric evaluation in women with breast cancer. Oncol Nurs Forum 25(4):677–684
Beck AT et al (1988) An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol 56(6):893–897
Wagner LI, Cella D (2004) Fatigue and cancer: causes, prevalence and treatment approaches. Br J Cancer 91(5):822–828
Young KE, White CA (2006) The prevalence and moderators of fatigue in people who have been successfully treated for cancer. J Psychosom Res 60(1):29–38
Hewitt JA et al (2005) Exercise for breast cancer survival: the effect on cancer risk and cancer-related fatigue (CRF). Int J Fertil Womens Med 50(5 Pt 1):231–239
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Sprod, L.K., Hsieh, C.C., Hayward, R. et al. Three versus six months of exercise training in breast cancer survivors. Breast Cancer Res Treat 121, 413–419 (2010). https://doi.org/10.1007/s10549-010-0913-0
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DOI: https://doi.org/10.1007/s10549-010-0913-0