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The effect of hyperbaric oxygenation therapy on myocardial function

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Abstract

Hyperbaric oxygenation therapy is successfully implemented for the treatment of several disorders. Data on the effect of hyperbaric oxygenation on echocardiographic parameters in asymptomatic patients is limited. The current study sought to evaluate the effect of hyperbaric oxygenation therapy on echocardiographic parameters in asymptomatic patients. Thirty-one consecutive patients underwent a 60-sessions course of hyperbaric oxygenation therapy in an attempt to improve cognitive impairment. In all subjects, echocardiography examination was performed before and after a course of hyperbaric oxygenation therapy. Conventional and speckle tracking imaging parameters were calculated and analyzed. The mean age was 70 ± 9.5 years, 28 [90%] were males. History of coronary artery disease was present in 12 [39%]. 94% suffered from hypertension, 42% had diabetes mellitus. Baseline wall motion abnormalities were found in eight patients, however, global ejection fraction was within normal limits. During the study, ejection fraction [EF], increased from 60.71 ± 6.02 to 62.29 ± 5.19%, p = 0.02. Left ventricular end systolic volume [LVESV], decreased from 38.08 ± 13.30 to 35.39 ± 13.32 ml, p = 0.01. Myocardial performance index [MPi] improved, from 0.29 ± 0.07 to 0.26 ± 0.08, p = 0.03. Left ventricular [LV] global longitudinal strain increased from − 19.31 ± 3.17% to − 20.16 ± 3.34%, p = 0.036 due to improvement in regional strain in the apical and antero-septal segments. Twist increased from 18.32 ± 6.61° to 23.12 ± 6.35° p = 0.01, due to improvement in the apical rotation, from 11.76 ± 4.40° to 16.10 ± 5.56°, p = 0.004. Hyperbaric oxygen therapy appears to improve left ventricular function, especially in the apical segments, and is associated with better cardiac performance. If our results are confirmed in further studies, HBOT can be used in many patients with heart failure and systolic dysfunction.

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Authors and Affiliations

  1. Department of Cardiology, Shamir Medical Center, Zerifin, Israel

    Marina Leitman, Shmuel Fuchs & Zvi Vered

  2. Sagol Center for Hyperbaric Medicine and Research, Shamir Medical Center, Zerifin, Israel

    Shai Efrati & Amir Hadanny

  3. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    Marina Leitman, Shai Efrati, Shmuel Fuchs, Amir Hadanny & Zvi Vered

  4. Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

    Shai Efrati & Amir Hadanny

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  1. Marina Leitman
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  2. Shai Efrati
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Correspondence to Marina Leitman.

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Our study was approved by the local Helsinki Committee and was done in accordance with the ethical standards of the local Helsinki Committee.

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10554_2020_1773_MOESM1_ESM.avi

Video 1. Apical 3-chamber view of a 68-year old healthy man, mentioned in figure 1, before and after HBOT therapy. After HBOT contraction of the left ventricle improved. A. Before HBOT. B. After HBOT (AVI 1946 kb)

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Leitman, M., Efrati, S., Fuchs, S. et al. The effect of hyperbaric oxygenation therapy on myocardial function. Int J Cardiovasc Imaging 36, 833–840 (2020). https://doi.org/10.1007/s10554-020-01773-0

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