A new tyramine derivative, glycosamide A (1), together with two known amide alkaloids, N-benzoyltyramine methyl ether (2) and aurantiamide acetate (3), was isolated from the branches and leaves of Glycosmis craibii Tanaka. Their structures were elucidated through extensive 1D and 2D NMR and HR-ESI-MS spectroscopic analyses. All known compounds were isolated from the genus Glycosmis for the first time. Furthermore, the antiproliferative activities of all isolated alkaloids in vitro were evaluated. Compound 2 displayed weak antiproliferative activities against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480.
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Acknowledgment
This project was supported by the National Natural Science Foundation of China (Nos. 31900297 and 31670363), the Science and Technology Planning Project of Guangdong Province (Nos. 2016A030307021, 2018A0303070005, and 2018A030307037), the Science and Technology Projects of Taizhou (No. 1901ny11), and the Special program for Natural Science Talents of Lingnan Normal University (No. ZL1903).
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2021, pp. 764–767.
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Wu, SY., Chen, ZM., Huang, GL. et al. A New Tyramine Derivative from the Branches and Leaves of Glycosmis craibii. Chem Nat Compd 57, 894–898 (2021). https://doi.org/10.1007/s10600-021-03505-9
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DOI: https://doi.org/10.1007/s10600-021-03505-9