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Two New Sesquiterpenes from the Stems of Fissistigma maclurei

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Chemistry of Natural Compounds Aims and scope

Two new sesquiterpenes, 7-hydroxy-15-nor-α-cadin-4-one (1) and 15-nor-α-cadin-4-one (2), together with six known sesquiterpenes (3–8), were isolated from the stems of Fissistigma maclurei Merr. Their structures were elucidated using comprehensive spectroscopic methods. All compounds were evaluated on their anti-inflammatory activities via testing the inhibitory activities against nitric oxide (NO) production induced by lipopolysaccharides in mouse macrophage RAW 264.7 cells in vitro.

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Acknowledgment

This work was supported by the Hainan Province Natural Science Foundation (218QN234), the National Natural Science Foundation of China (21662012 and 41866005), the Hainan Province Natural Science Foundation of Innovative Research Team Project (2016CXTD007), and the Innovative Research Team Project of Ministry (IRT-16R19).

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Authors and Affiliations

  1. Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, 571158, Haikou, P. R. China

    Yu-Xi Luo, You Wu, Cheng-Cong Zhu, Wan-Ting Wang, Jia-Jun Huang & Xue-Ming Zhou

  2. Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, 571158, Haikou, P. R. China

    Yu-Xi Luo, Cheng-Cong Zhu, Wan-Ting Wang, Jia-Jun Huang & Xue-Ming Zhou

  3. Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, School of Chemistry and Materials Engineering, Hainan Vocational University of Science and Technology, 571126, Haikou, P. R. China

    You Wu & De-Cai Dai

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  1. Yu-Xi Luo
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  2. You Wu
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  3. De-Cai Dai
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  4. Cheng-Cong Zhu
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  5. Wan-Ting Wang
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  7. Xue-Ming Zhou
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Correspondence to Xue-Ming Zhou.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2022, pp. 244–246.

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Luo, YX., Wu, Y., Dai, DC. et al. Two New Sesquiterpenes from the Stems of Fissistigma maclurei. Chem Nat Compd 58, 279–282 (2022). https://doi.org/10.1007/s10600-022-03659-0

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  • DOI: https://doi.org/10.1007/s10600-022-03659-0

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