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Short-duration transient visual evoked potential for objective measurement of refractive errors

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Abstract

This study examined effects of uncorrected refractive errors (RE) in a short-duration transient visual evoked potential (SD t-VEP) system and investigated their role for objective measurement of RE. Refractive errors were induced by means of trial lenses in 35 emmetropic subjects. A synchronized single-channel EEG was recorded for emmetropia, and each simulated refractive state to generate 21 VEP responses for each subject. P100 amplitude (N75 trough to P100 peak) and latency were identified by an automated post-signal processing algorithm. Induced hypermetropia and myopia correlated strongly with both P100 amplitude and latency. To minimize the effect of baseline shift and waveform fluctuations, a VEP scoring system, based on software-derived P100 latency, amplitude and waveform quality, was used to estimate the RE. Using the VEP scores, a single VEP response had a high sensitivity and specificity for discerning emmetropia, small RE (<2 diopter) within a 2 diopter range and large RE (2–14 diopter) within a 4 diopter range. The VEP scoring system has a potential for objective screening of RE and for a more accurate 3-step objective refraction.

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Conflict of interests

Aashish Anand: None; Carlos Gustavo V De Moraes: None; Christopher C Teng: None; Jeffrey M Liebmann: Served as a consultant for Diopsys, Inc., Allergan, Inc., Alcon Laboratories, Inc., Optovue, Inc., Quark Pharmaceuticals, Inc., Topcon Medical Systems, Inc., Grant support from Carl Zeiss Meditec, Diopsys, Inc., Heidelberg Engineering, Optovue, Inc., Topcon Medical Systems; Robert Ritch: Invited lectures for Alcon Laboratories, Inc., Allergan, Inc., Merck, Inc., Pfizer, Inc.; Celso Tello: Served as a consultant for Diopsys, Inc., SOLX, Inc., Invited lectures for Alcon Laboratories, Inc., Allergan, Inc.

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Authors and Affiliations

  1. Einhorn Clinical Research Center, New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY, 10003, USA

    Aashish Anand, Carlos Gustavo V. De Moraes, Christopher C. Teng, Jeffrey M. Liebmann, Robert Ritch & Celso Tello

  2. Department of Ophthalmology, New York Medical College, Valhalla, NY, USA

    Robert Ritch & Celso Tello

  3. New York University School of Medicine, New York, NY, USA

    Carlos Gustavo V. De Moraes, Christopher C. Teng & Jeffrey M. Liebmann

Authors
  1. Aashish Anand
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  2. Carlos Gustavo V. De Moraes
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  3. Christopher C. Teng
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  4. Jeffrey M. Liebmann
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  5. Robert Ritch
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  6. Celso Tello
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Correspondence to Celso Tello.

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Anand, A., De Moraes, C.G.V., Teng, C.C. et al. Short-duration transient visual evoked potential for objective measurement of refractive errors. Doc Ophthalmol 123, 141–147 (2011). https://doi.org/10.1007/s10633-011-9289-7

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  • DOI: https://doi.org/10.1007/s10633-011-9289-7

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