Abstract
Radon is a radioactive gas that can migrate from soils and rocks and accumulate in indoor areas such as dwellings and buildings. Many studies have shown a strong association between the exposure to radon, and its decay products, and lung cancer (LC), particularly in miners. In Mexico, according to published surveys, there is evidence of radon exposure in large groups of the population, nevertheless, only few attention has been paid to its association as a risk factor for LC. The aim of this ecological study is to evaluate the excess risk of lung cancer mortality in Mexico due to indoor radon exposure. Mean radon levels per state of the Country were obtained from different publications and lung cancer mortality was obtained from the National Institute of Statistics, Geography and Informatics for the period 2001–2013. A model proposed by the International Commission on Radiological Protection to estimate the annual excess risk of LC mortality (per 105 inhabitants) per dose unit of radon was used. The average indoor radon concentrations found rank from 51 to 1863 Bq m−3, the higher average dose exposure found was 3.13 mSv year−1 in the north of the country (Chihuahua) and the mortality excess of LC cases found in the country was 10 ± 1.5 (range 1–235 deaths) per 105 inhabitants. The highest values were found mainly in the Northern part of the country, where numerous uranium deposits are found, followed by Mexico City, the most crowded and most air polluted area in the country. A positive correlation (r = 0.98 p < 0.0001) was found between the excess of LC cases and the dose of radon exposure. Although the excess risk of LC mortality associated with indoor radon found in this study was relatively low, further studies are needed in order to accurately establish its magnitude in the country.
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References
Al-Zoughool, M., & Krewski, D. (2009). Health effects of radon: A review of the literature. International Journal on Radiation and Biology, 85(1), 57–69.
Arce, J. L., Walker, J., & Keppie, J. D. (2015). Petrology and geochemistry of El Chichón and Tacaná: Two active, yet contrasting Mexican volcanoes. In T. Scolamacchia & J. L. Macías (Eds.), Active volcanoes of Chiapas (Mexico): El Chichón and Tacaná (pp. 25–43). Berlin: Springer. ISBN 978-3-642-25890-9.
Arrieta, O., Ramírez, T. L. A., Báez, S. R., Peña, C. O., Soca, C. H. U., & Macedo, P. O. E. (2015). Different mutation profiles and clinical characteristics among Hispanic patients with non-small cell lung cancer could explain the “Hispanic Paradox”. Lung Cancer, 90, 161–166.
Axelson, O. (1995). Cancer risk from exposure to radon in homes. Environmental Health Perspectives, 103(Suppl 2), 37–43.
Baeza, A., Garcia, J., Guillen, J., & Montalban, E. (2018). Influence of architectural style on indoor radon concentration in a radon prone area: A case study. The Science of the Total Environment, 610–611, 258–266.
Bazán, B. S. (1978). Génesis y depositación de los yacimientos de milibdeno y uranio, en el Distrito de Villa Aldama y Chihuahua. Boletin de la Sociedad Geologica Mexicana, 39(2), 29–33.
Bem, H., Dlugosz-Liiecka, M., Janiak, S., Mazurek, D., & Szajerski, P. (2017). Fast determination of indoor radon (222Rn) concentration using liquid scintillation counting. Journal of Radioanalytical and Nuclear Chemistry, 312, 337–342.
Canet, C., Rodríguez-Díaz, A. A., Bernal, I. D., Pi, T., Sánchez-Córdova, M. M., et al. (2019). Consideraciones sobre el sistema geotérmico de San Bartolomé de los baños, Guanajuato (México), desde un análisis de las inclusiones fluidas. Geofísica Internacional, 58–3, 229–246.
Canoba, A., Lopez, F., Amaud, M., Oliveira, A., Neman, R., Hadler, J., et al. (2002). Indoor radon measurements in six Latin American Countries. Geofisica International, 41, 453–457.
Catelinois, O., Rogel, A., Laurier, D., Billon, S., Hemon, D., Verger, P., et al. (2006). Lung cancer attributable to indoor radon exposure in France: Impact of the risk models and uncertainty analysis. Environmental Health Perspectives, 114(9), 1361–1366.
Chen, J. (2017). Canadian population risk of radon induced lung-cancer variation range assessment based on various radon risk models. Radiation Protection Dosimetry, 177(1-2), 63–68.
Chen, J. (2019). Risk assessment for radon exposure in various indoor environments. Radiation Protection Dosimetry, 185(2), 143–150.
Colmenero, L., Montero, M. E., Villalba, L., Rentería, M., Torres, E., Garcia, M., et al. (2004). Uranium-238 and thorium-232 series concentrations in soil, radon-222 indoor and drinking water concentrations and dose assessment in the city of Aldama, Chihuahua, Mexico. Journal of Environmental Radioactivity, 77(2), 205–219.
Darby, S., Hill, D., Auviden, A., Barros-Dios, J. M., Baysson, H., Bochicchio, F., et al. (2005). Radon in homes and risk of lung cancer. Collaborative analysis of individual data from 13 European case-control studies. British Medical Journal, 330, 223–227.
Darby, S., Hill, D., Deo, H., Auviven, A., Barros-Dios, J. M., & Baysson, H. (2006). Residential radon and lung cancer—Detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14,208 persons without lung cancer from 13 epidemiological studies in Europe. Scandinavian Journal of Work, Environment & Health, 32(Suppl 1), 1–84.
Demoury, C., Lelsch, G., Hemon, D., Laurent, O., Laurier, D., Clavel, I., et al. (2013). A statistical evaluation of the influence of houses characteristics and geogenic radon potential on indoor radon concentrations in France. Journal of Environmental Radioactivity, 126, 216–225.
DGE (Dirección General de Epidemiología). (2018). Epidemiological Information. Consulted in 2018. https://www.gob.mx/salud/acciones-y-programas/informacion-epidemiologica.
Dobrzynski, L., Krzysztof, W. F., & Reszcynska, J. (2018). Meta-analysis of thirty-two case-control and two ecological radon studies of lung cancer. Journal of Radiation Research, 2, 149–163.
Espinosa, G., & Gammage, R. B. (1997). Long-term radon survey in Mexico City and other regions of the Country. Radiation Measurements, 28(I-6), 663–665.
Espinosa, G., & Gammage, R. B. (2011). An indoor radon survey in three different climate regions in Mexico, and the influence of climate in the obtained values. Journal of Environmental Protection, 2, 1143–1148.
Espinosa, G., Golzarri, J. I., Angeles, A., & Griffith, R. (2009). Nationwide survey of radon levels in indoor workplaces in Mexico using Nuclear Track Methodology. Radiation Measurements, 44, 1051–1054.
Espinosa, G., Golzarri, J. I., Bogard, J., Gaso, I., Ponciano, G., Mena, M., et al. (2008). Indoor radon measurements in Mexico City. Radiation Measurements, 43, 431–434.
Espinosa, G., Golzarri, J. I., Rickards, R., & Gammage, R. B. (1999). Distribution of indoor radon levels in Mexico. Radiation Measurements, 31, 355–358.
Ferlay, J., Soerjomatoram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., et al. (2015). Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer, 136(5), E359–E386.
Franco-Marina, F., Segovia, N., Ruiz, W., Godinez, L., Tavera, L., Lopez, A., et al. (2001). Short and long term indoor radón survey in Mexico City. Radiation Measurements, 34, 545–548.
Franco-Marina, F., Villalba, C. J., Segovia, N., & Tavera, L. (2003). Spatial indoor radon distribution in Mexico City. The Science of the Total Environment, 317, 91–103.
Gaso, M. I., Segovia, N., Pulinets, S., Leyva, A., Ponciano, G., & Peña, P. (2005). Indoor radon and annual effective doses at high altitude region in Central Mexico. Journal of Applied Science, 5(8), 1356–1362.
Harrison, J. D., & Marsh, J. W. (2012). Effective dose from inhaled radon and its progeny. Annals of the ICRP, 41, 378–388.
Hart, J. (2011). On ecological studies: A short communication. Dose Response, 9, 497–501.
Hinojosa de la Garza, O. R., Sanín, L. H., Montero Cabrera, M. E., Serrano Ramirez, K. I., Martínez Meyer, E., & Cortés, M. R. (2014). Lung cancer mortality and radon concentration in a chronically exposed neighborhood in Chihuahua, Mexico: A geospatial analysis. Scientific World Journal. https://doi.org/10.1155/2014/935380.
IAEA (International Atomic Energy Agency). (2015). Protection of the public against exposure indoors due to radon and other natural sources of radiation. IAEA Safety Standard Series No. SSG-32, Vienna.
IARC (International Agency for Research on Cancer) and WHO (World Health Organization). (1988). IARC monographs on the evaluation of the carcinogenic risks to human. Man-Made Mineral Fibers and Radon, 43, 1–300.
IARC News. Media Centre- IARC News. World Cancer Day 2016. “We can.I can”. 4/02/2016. https://www.iarc.fr/media-centre-iarc-news-wcd2016/.
ICRP (International Commission on Radiological Protection). (1993). Protection against radon at home and at work. Publication 65. Annals of the ICRP, 23(2), 1–45.
INEGI (Instituto Nacional de Estadística, Geografía e Informática). (2010). Consulted in 2020. https://www.inegi.org.mx/programas/ccpv/2010/.
Kandari, T., Aswal, S., Trasad, M., Bourai, A. A., & Ramola, R. C. (2016). Estimation of annual effective dose from radon concentration along Main Boundary Thrust (MBT) in Garhwal Himalaya. Journal of Radiation Research and Applied Sciences, 9, 228–233.
Karpinska, M., Mnich, Z., Kapala, J., & Szpak, A. (2009). The evaluation of indoor radon exposure in houses. Polish Journal of Environmental Studies, 18(6), 1005–1012.
Krewski, D., Lubin, J. H., & Zlellinski, J. M. (2005). Residential radon and risk of lung cancer. Combined analysis of 7 North American case-control studies. Epidemiology, 16, 137–145.
Lerma-Treviño, C., Rubio-Arias, H., Colmenero-Sujo, L. H., Villalba, M. L., & Ochoa-Rivero, J. M. (2018). Indoor radon gas (222Rn) levels n homes in Aldama, Chihuahua, Mexico and the risk of lung cancer. International Journal of Envirnomental Resesearch and Public Health, 15, 1337–1345.
López-Abente, G., Núñez, O., Fernández-Navarro, P., Barros-Dios, J. M., Martin- Méndez, J., et al. (2018). Residential radon and cancer mortality in Galicia, Spain. Science of the Total Environment, 610–611, 1125–1132.
McCarthy, W. J., Meza, R., Jeon, J., & Moolgavkar, S. (2012). Lung cancer in never smokers epidemiology and risk prediction models. Risk Analysis, 2(32 suppl 1), S69–S84.
Menzler, S., Piller, G., Gruson, M., Rosario, A. S., Wichrnann, H. E., & Kreienbrock, I. (2008). Population attributable fraction for lung cancer due to residential radon in Switzerland and Germany. Health Physics, 95, 179–189.
Mireles, F., García, M. L., Quirino, L. L., Davila, J. I., Pinedo, J. L., Ríos, C., et al. (2007). Radon survey related to construction materials and soils in Zacatecas, México using LR-115. Radiation Measurements, 42, 1397–1403.
Montero, M. E., Colmenero, L., Villalba, L., De la Cruz, S., Saenz, J., & Renteria, M. (2005). Rn-222 air concentrations in Chihuahua state (Mexico) dwellings and in the US/Mexico border. Microchemistry Journal, 81, 28–34.
Murillo-Zamora, E., Mendoza-Cano, O., Ríos-Silva, M., Sánchez-Piña, R. A., Higareda-Almazaán, M. A., Higareda-Almazán, E., et al. (2018). Disability-adjusted life years for cancer in 2010–2014: A regional approach in Mexico. International Journal of Environmental Research and Public Health, 15, 864–873.
NRPB. (1991). National Radiological Protection Board, Chilton NRPB annual report 1990–1991 (INIS-GB–373). United Kingdom.
Rentería, V. M., Montero, C. M. E., Reyes, C. M., Herrera, P. E. F., Rodríguez, P. A., Manjón, C. G., et al. (2007). Characterization of source rocks and groundwater radioactivity at Chihuahua Valley. Revista Mexicana de Fisica, S53, 16–22.
Rizo, R. P., Gonzalez, R. A., Sanchez, C. F., & Murguia, M. P. (2015). Trends in cancer mortality in Mexico: 1990–2012. Revista Médica del Hospital General de. México, 78, 85–94.
Roscoe, J. R., Steenland, K., & Halperin, E. W. (1989). Lung cancer mortality among nonsmoking uranium miners exposed to radon daughters. JAMA, 262(5), 629–633.
Ruiz-Godoy, L., Rizo, R. P., Sánchez, C. F., Osornio-Vargas, A., García-Cuellar, C., & Meneses, G. A. (2007). Mortality due to lung cancer in Mexico. Lung Cancer, 58, 184–190.
Sahoo, B. K., Nathwani, D., Eappen, K. P., Ramachandran, T. V., Gaware, J. J., & Mayya, Y. S. (2007). Estimation of radon emanation factor in Indian building materials. Radiation Measurements, 42, 1422–1425.
Sedgwick, P. (2014). Ecological studies: Advantages and disadvantages. BMJ, 348, g2979–g2980.
Segovia, N., Gaso, M. I., & Armienta, A. (2007). Environmental radon studies in Mexico. Environmental Geochemistry and Health, 29, 143–153.
Segovia, N., Peña, P., Mireles, F., Dávila, I., & Wuirino, L. (1993). Radon concentration levels in dwellings and mine atmospheres in Mexico. Nuclear Tracks and Radiation Measurements, 22, 445–448.
Segovia, N., Ponciano, G., Ruiz, W., & Godinez, L. (2002). Indoor radon and airborne particles. Geofisica Internacional, 41(3), 255–259.
Sherafat, S., Nemati, M. S., Mosaferi, M., Aminisani, N., Yousefi, Z., & Maleki, S. (2019). First radon mapping and assessment excess lifetime cancer risk in Iran. MethodsX, 6, 2205–2216.
Singh, P., Singh, P., Singh, S., Sahoo, B. K., Sapra, B. K., & Bajwa, B. S. (2015). A study of indoor radon, thoron and their progeny measurement in Tosham region Haryana, India. Journal of Radiation Research and Applied Science, 8, 226–233.
Tirmarche, M., Harrison, J. D., Laurier, D., Paquet, F., Blanchardon, E., & Marsh, J. W. (2010). Lung cancer risk from radon and progeny and statement on radon. ICRP Publication 115. Annals of the ICRP, 40(1), 1–64.
UNSCEAR (United Nations Scientific Committee on Effects of Atomic Radiation). (2000). Sources and biological effects of ionizing radiation. New York: United Nations.
UNSCEAR (United Nations Scientific Committee on Effects of Atomic Radiation). (2009). Sources and biological effects of ionizing radiation. New York, United Nations. Report to the General Assembly with Scientific Annexes. Vol I and II.
US-EPA. (2014). Assessment of risk from radon in homes. Washington, DC: Office of Radiation and Indoor Air.
US-EPA (US-Environmental Protection Agency). (2012). A citizen´s guide to radon: The guide to protecting yourself and your family from radon.
US-EPA (US-Environmental Protection Agency). Document 402-R-92-004. (2002). Indoor radon and indoor decay product measurement device protocols. Washington, DC: Office of Radiation Programs.
US-EPA (US-Environmental Protection Agency). (2003). EPA Assessment of Risks from radon in homes. EPA 402-R-03-003. June 2003. Washington, D.C.
WHO (World Health Organization). (2009). WHO Handbook on Indoor Radon. ISBN: 9789241547673.
WHO (World Health Organization). (2011). Fact sheet N° 292, Indoor air pollution and health. http://www.who.int/mediacentre/factsheets/fs292/es/.
WHO (World Health Organization). (2013). WHO Report on the global tobacco epidemic, 2013. Enforcing bans on tobacco advertising, promotion and sponsorship. ISBN 9789240691605.
WHO (World Health Organization) (2017). Guide to cancer early diagnosis. ISBN: 9789241511940.
Yoon, Y. J., Lee, D. J., Joo, W. S., & Kang, R. D. (2016). Indoor radon exposure and lung cancer; a review of ecological studies. Journal of Occupational and Environmental Medicine, 28, 15–23.
Zhang, Z. L., Sun, J., Dong, J. Y., Tian, H. L., Xue, L., Qin, L. Q., et al. (2012). Residential radon and lung cancer risk: An updated meta-analysis of case-control studies. Asian Pacific Journal on Cancer Prevention, 13, 2459–2465.
Acknowledgements
This paper is devoted to the loving memory of Dr. Ramiro Rodriguez, an enthusiastic collaborator and friend who always showed great enthusiasm to generate knowledge in benefit of his country, students and the University. Unfortunately, he passed away in 2017. We acknowledge the wise comments of the reviewers that improved the manuscript. Also to Carlos Alberto Chávez Castillo for English editing and help with the Figures.
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This study was partially supported by a grant from the National Council of Science and Technology (CONACyT).
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Ponciano-Rodríguez, G., Gaso, M.I., Armienta, M.A. et al. Indoor radon exposure and excess of lung cancer mortality: the case of Mexico—an ecological study. Environ Geochem Health 43, 221–234 (2021). https://doi.org/10.1007/s10653-020-00662-8
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DOI: https://doi.org/10.1007/s10653-020-00662-8