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Prognostic impact of diabetes in chronic and acute heart failure

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Abstract

A strong, bidirectional relationship exists between diabetes mellitus (DM) and heart failure (HF) and DM is responsible of the activation of several molecular and pathophysiological mechanisms that may, on the long term, damage the heart. However, the prognostic role of DM in the context of chronic and acute HF is still not yet defined and there are several gaps of evidence in the literature on this topic. These gaps are related to the wide phenotypic heterogeneity of patients with chronic and acute HF and to the concept that not all diabetic patients are the same, but there is the necessity to better characterize the disease and each single patient, also considering the role of other possible comorbidities. The aim of the present review is to summarize the pathophysiological mechanisms subtending the negative effect of DM in HF and analyze the available data exploring the prognostic impact of such comorbidity in both chronic and acute HF.

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Authors and Affiliations

  1. Divisione Di Cardiologia, Fondazione IRCCS Policlinico S.Matteo, 27100, Pavia, Italy

    Stefano Ghio & Andrea Attanasio

  2. Dipartimento Di Scienze Mediche Traslazionali, Università Degli Studi Di Napoli Federico II, Napoli, Italy

    Valentina Mercurio & Carlo Gabriele Tocchetti

  3. Dipartimento Di Medicina Molecolare, Università Di Pavia, Pavia, Italy

    Andrea Attanasio

  4. Dipartimento Di Scienze Biomediche Avanzate, Università Degli Studi Di Napoli Federico II, Napoli, Italy

    Gaetano Asile & Stefania Paolillo

  5. Mediterranea Cardiocentro, Napoli, Italy

    Stefania Paolillo

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  1. Stefano Ghio
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  2. Valentina Mercurio
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  3. Andrea Attanasio
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  5. Carlo Gabriele Tocchetti
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Contributions

SG and SP made substantial contributions to the conception and design of the work, drafted the work, and revised it critically for important intellectual content; VM and CGT made substantial contribution on literature analysis, drafted part of the work, and revised it critically for important intellectual content; AA and GA made substantial contribution on literature analysis, drafted part of the work, and revised it critically for important intellectual content. All authors approved the version to be published and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Correspondence to Stefano Ghio.

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Ghio, S., Mercurio, V., Attanasio, A. et al. Prognostic impact of diabetes in chronic and acute heart failure. Heart Fail Rev 28, 577–583 (2023). https://doi.org/10.1007/s10741-021-10193-8

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