Abstract
The aim of our study is to investigate the long-term transitions of intraocular pressure (IOP) and aqueous flare values in uveitis patients with faint anterior chamber flare who were treated with once-daily topical ophthalmic betamethasone for more than 6 months. The study included a total of 111 eyes of 68 outpatients. The mean follow-up period was 26.8 months. The average IOP and aqueous flare value of patients divided by the 5-months follow-up period showed no significant difference. Six eyes (of four patients) were followed-up for more than 1 year after termination of the treatment. Among these patients, the average aqueous flare value was significantly higher, and the average period to reach more than 1.5 times the former aqueous flare value significantly decreased after termination than before. Once-daily topical ophthalmic betamethasone is not expected to cause steroid-induced ocular hypertension but to have prophylactic effect.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Carnahan, M.C., and D.A. Goldstein. 2000. Ocular complications of topical, peri-ocular, and systemic corticosteroids. Current Opinion in Ophthalmology 11: 478–483.
Kersey, J.P., and D.C. Broadway. 2006. Corticosteroid-induced glaucoma: a review of the literature. Eye (London) 20: 407–416.
Jones 3rd, R., and D.J. Rhee. 2006. Corticosteroid-induced ocular hypertension and glaucoma: a brief review and update of the literature. Current Opinion in Ophthalmology 17: 163–167.
Moorthy, R.S., A. Mermoud, G. Baerveldt, D.S. Minckler, P.P. Lee, and N.A. Rao. 1997. Glaucoma associated with uveitis. Survey of Ophthalmology 41: 361–394.
BenEzra, D., Y.S. Wysenbeek, and E. Cohen. 1997. Increased intraocular pressure during treatment for chronic uveitis. Graefe’s Archive for Clinical and Experimental Ophthalmology 235: 200–203.
Tripathi, R.C., S.K. Parapuram, B.J. Tripathi, Y. Zhong, and K.V. Chalam. 1999. Corticosteroids and glaucoma risk. Drugs & Aging 15: 439–450.
Siddique, S.S., A.M. Suelves, U. Baheti, and C.S. Foster. 2013. Glaucoma and uveitis. Survey of Ophthalmology 58: 1–10.
Jabs, D.A., R.B. Nussenblatt, and J.T. Rosenbaum. 2005. Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. American Journal of Ophthalmology 140: 509–516.
Chin, P.K., O.E. Cuzzani, H.V. Gimbel, and R. Sun. 1996. Effect of commercial dilating agents on laser flare-cell measurements. Canadian Journal of Ophthalmology 31: 362–365.
Zaczek, A., and C. Zetterström. 2000. The effect of phenylephrine on pain and flare intensity in eyes with uveitis. Acta Ophthalmologica Scandinavica 78: 516–518.
Petternel, V., O. Findl, A. Kruger, J. Schauersberger, and M. Amon. 2000. Effect of tropicamide on aqueous flare before and after cataract surgery. Journal of Cataract & Refractive Surgery 26: 382–385.
Oshika, T., and S. Kato. 1989. Changes in aqueous flare and cells after mydriasis. Japanese Journal of Ophthalmology 33: 271–278.
Schemer, W.J., and F.A. Hauber. 2000. Effect of latanoprost on intraocular pressure in steroid-induced glaucoma. Journal of Glaucoma 9: 179–182.
Sung, V.C., and K. Barton. 2004. Management of inflammatory glaucomas. Current Opinion in Ophthalmology 15: 136–140.
Clark, A.F., and R.J. Wordinger. 2009. The role of steroids in outflow resistance. Experimental Eye Research 88: 752–759.
Meacock, W.R., D.J. Spalton, L. Bender, R. Antcliff, C. Heatley, M.R. Stanford, and E.M. Graham. 2004. Steroid prophylaxis in eyes with uveitis undergoing phacoemulsification. British Journal of Ophthalmology 88: 1122–1124.
Shah, S.M., D.J. Spalton, and J.C. Taylor. 1992. Correlations between laser flare measurements and anterior chamber protein concentrations. Investigative Ophthalmology & Visual Science 33: 2878–2884.
Saari, K.M., O.M. Guillén-Monterrubio, J. Hartikainen, M.M. Hämäläinen, and K. Taskinen. 1997. Measurement of protein concentration of aqueous humour in vivo: correlation between laser flare measurements and chemical protein determination. Acta Ophthalmologica Scandinavica 75: 63–66.
Guillén-Monterrubío, O.M., J. Hartikainen, K. Taskinen, and K.M. Saari. 1997. Quantitative determination of aqueous flare and cells in healthy eyes. Acta Ophthalmologica Scandinavica 75: 58–62.
Konstantopoulou, K., R. Del’omo, A.M. Morley, D. Karagiannis, C. Bunce, and C. Pavesio. 2012. A comparative study between clinical grading of anterior chamber flare and flare reading using the Kowa laser flare meter. International Ophthalmology. doi:10.1007/s10792-012-9616-3.
Mataftsi, A., A. Narang, W. Moore, and K.K. Nischal. 2011. Do reducing regimens of fluorometholone for paediatric ocular surface disease cause glaucoma? British Journal of Ophthalmology 95: 1531–1533.
ACKNOWLEDGMENTS
Funding/Support
This study was supported in part by a Strategic Research Foundation Grant for the aid of Projects in Private Universities, offered by the Ministry of Education, Culture, Sports, Science, and Technology, Japan (MEXT), 2011–2015 (S1101027).
Role of the Sponsor
The sponsor had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Conflict of Interest Disclosures
None reported.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kawamura, M., Zako, M. Long-Term Stability of Uveitis with Faint Anterior Chamber Flare Treated with Once-Daily Topical Ophthalmic Betamethasone. Inflammation 37, 417–425 (2014). https://doi.org/10.1007/s10753-013-9754-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10753-013-9754-4