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Role of Aquaporins in Inflammation—a Scientific Curation

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Abstract

Inflammation is a universal response mechanism existing as inter-communicator of biological systems. Uncontrolled or dysregulated inflammation addresses chronic low-grade effects eventually resulting in multimorbidity. Active solute transport across the membrane establishes varying osmotic gradients. Aquaporins (AQPs) are a class of critical ubiquitously expressed transmembrane proteins that aid in fluid and small solute transport via facilitated diffusion over established osmotic gradients. Numerous significant data features the biological functions of AQPs rendering them as an appropriate biomarker of health and diseases. Besides their physiological role in well-balanced inflammatory responses, it is worth noting the dysregulation of AQPs during any undesirable inflammatory event. Most literature to date clearly sets out AQPs as potential drug targets instigating AQP-based therapies. In light of this conception, the current review provides a compendious overview on the propitious and portentous out-turns of AQPs under inflammation.

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Abbreviations

AKI:

Acute kidney injury

AQPs:

Aquaporins

ASC:

Inflammasome adaptor protein apoptosis-associated speck-like protein containing CARD

Bax:

Bcl-2- associated X protein

BBB:

Blood brain barrier

COX:

Cyclooxygenase

CREB:

cAMP response element binding protein

ERK:

Extracellular signal-regulated kinase

IKKB:

Inhibitor of kappa B kinase

IL:

Interleukin

INF:

Interferon

JAK:

Janus kinase

KO mice:

Knockout mice

LPS:

Lipopolysaccharides

MAPK:

Mitogen-activated protein kinase

MCP:

Monocyte chemoattractant protein

MHC:

Major histocompatibility complex

NF- κB:

Nuclear factor kappa B

NMO:

Neuromyelitis optica

SS:

Sjogrens syndrome

STAT:

Signal transducer and activator of transcription

TGF:

Transforming growth factor

TNF-α:

Tumor necrosis factor alpha

WT:

Wild type

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Authors and Affiliations

  1. Molecular Endocrinology Laboratory, Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620024, India

    Lezy Flora Mariajoseph-Antony, Arun Kannan, Antojenifer Panneerselvam, Chithra Loganathan & Chidambaram Prahalathan

  2. Department of Life Sciences, School of Life Sciences, Central University of Tamil Nadu, Thiruvarur, 610005, India

    Esaki M. Shankar

  3. Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli, 620024, India

    Kumarasamy Anbarasu

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  1. Lezy Flora Mariajoseph-Antony
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LFMA: conceptualization and initial draft. CP: design and supervision. CP, ES, KA, AK, AP, CL: critical revision and suggestions. All the authors discussed and approved the final manuscript.

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Mariajoseph-Antony, L.F., Kannan, A., Panneerselvam, A. et al. Role of Aquaporins in Inflammation—a Scientific Curation. Inflammation 43, 1599–1610 (2020). https://doi.org/10.1007/s10753-020-01247-4

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