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Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats

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Abstract

Objective

To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats.

Methods

Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochemical and histopathological analysis.

Results

Malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) levels were decreased (p < 0.05) in the targeted groups compared to the AA group, whereas nuclear factor-erythroid 2-related factor 2 (Nrf-2) level was increased (p < 0.05). Tumor necrosis factor α (TNF-α) level was also decreased (p < 0.05) and catalase activity (CAT) was increased (p < 0.05) in the TLC group compared to the AA group. IL-1β and IL-6 levels were lower in the TLC group compared to the conventional LC and sulfasalazine groups (p < 0.05). COX-2 and NF-κB levels were lower, while the Nrf-2 level was higher in the targeted groups compared to the conventional groups (p < 0.05). Furthermore, COX-2 level was lower and Nrf-2 level was higher in the targeted groups compared to the sulfasalazine group (p < 0.05).

Conclusion

As expected, sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC, which deserves to be investigated further.

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Acknowledgements

This work was financially supported by Scientific Research Projects Coordination of Mustafa Kemal University (project number: 14025).

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Mustafa Kemal University, 31060, Hatay, Turkey

    İbrahim Ozan Tekeli & Fatih Sakin

  2. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Fırat University, 23119, Elazığ, Turkey

    Ahmet Ateşşahin

  3. Department of Biology, Faculty of Science, Fırat University, 23119, Elazığ, Turkey

    Abdullah Aslan

  4. Department of Pathology, Faculty of Veterinary Medicine, Fırat University, 23119, Elazığ, Turkey

    Songül Çeribaşı

  5. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Namık Kemal University, 59030, Tekirdağ, Turkey

    Mustafa Yipel

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  1. İbrahim Ozan Tekeli
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Tekeli, İ.O., Ateşşahin, A., Sakin, F. et al. Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats. Inflammopharmacol 27, 313–322 (2019). https://doi.org/10.1007/s10787-018-0485-x

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