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Fabrication of electrospun polycaprolactone coated withchitosan-silver nanoparticles membranes for wound dressing applications

  • Biomaterials Synthesis and Characterization
  • Original Research
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Abstract

In this study, electrospun polycaprolactone membrane coated with chitosan-silver nanoparticles (CsAg), electrospun polycaprolactone/chitosan/Ag nanoparticles, was fabricated by immersing the plasma-treated electrospun polycaprolactone membrane in the CsAg gel. The plasma modification of electrospun polycaprolactone membrane prior to CsAg coating was tested by methylene blue stain and scanning electron microscope. The presence of silver and chitosan on the plasma-treated electrospun polycaprolactone membrane was confirmed by energy-dispersive X-ray spectroscopy and FT-IR spectrum. Scanning electron microscope observation was employed to observe the morphology of the membranes. The release of Ag ions from electrospun polycaprolactone/chitosan/Ag nanoparticles membrane was tested using atomic absorption spectrometry. Electrospun polycaprolactone/chitosan/Ag nanoparticles membrane inherited advantages from both CsAg gel and electrospun polycaprolactone membrane such as: increasing biocompatibility, mechanical strength, and antibacterial activity against both Gram-negative and Gram-positive bacteria. Thus, this investigation introduces a highly potential membrane that can increase the efficacy of the wound dressing process.

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Acknowledgments

The work relative with the PCL electrospun membranes is funded by Office of Navy Research (ONR) under grant number: N62909-14-1-N011-P00001, PR No: N6290914PR00015/N00014. The work relative with chitosan-AgNPs gel is funded by Vietnam National University-Ho Chi Minh City under grant number: B2013-76-03.

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Authors and Affiliations

  1. Tissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-Ho Chi Minh City (VNU-HCM), HCMC, 700000, Vietnam

    Tra Thanh Nhi, Huynh Chan Khon, Vo Van Toi & Nguyen Thi Hiep

  2. School of Biotechnology, International University, Vietnam National University-Ho Chi Minh City (VNU-HCM), HCMC, 700000, Vietnam

    Nguyen Thi Thu Hoai

  3. The Center for Molecular Biomedicine, University of Medicine and Pharmacy, HCMC, 700000, Vietnam

    Bui Chi Bao

  4. Department - Materiasl and Pharmaceutical chemistry, Institute of Applied Materials Science-Vietnam Academy of Science and Technology, VAST, HCMC, 700000, Vietnam

    Tran Ngoc Quyen

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  1. Tra Thanh Nhi
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  2. Huynh Chan Khon
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Correspondence to Nguyen Thi Hiep.

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Nhi, T.T., Khon, H.C., Hoai, N.T.T. et al. Fabrication of electrospun polycaprolactone coated withchitosan-silver nanoparticles membranes for wound dressing applications. J Mater Sci: Mater Med 27, 156 (2016). https://doi.org/10.1007/s10856-016-5768-4

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  • DOI: https://doi.org/10.1007/s10856-016-5768-4

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