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Effect of ethanol/TEOS ratios and amount of ammonia on the properties of copper-doped calcium silicate nanoceramics

  • Biomaterials Synthesis and Characterization
  • Original Research
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Abstract

Calcium magnesium silicate glasses could be suggested for the synthesis of scaffolds for hard tissue regeneration, as they present a high residual glassy phase, high hardness values and hydroxyapatite-forming ability. The use of trace elements in the human body, such as Cu, could improve the biological performance of such glasses, as Cu is known to play a significant role in angiogenesis. Nano-bioceramics are preferable compared to their micro-scale counterparts, because of their increased surface area, which improves both mechanical properties and apatite-forming ability due to the increased nucleation sites provided, their high diffusion rates, reduced sintering time or temperature, and high mechanical properties. The aim of the present work was the evaluation of the effect of different ratios of Ethanol/TEOS and total amount of the inserted ammonia to the particle size, morphology and bioactive, hemolytic and antibacterial behavior of nanoparticles in the quaternary system SiO2–CaO–MgO–CuO. Different ratios of Ethanol/TEOS and ammonia amount affected the size and morphology of bioactive nanopowders. The optimum materials were synthesized with the highest ethanol/TEOS ratio and ammonia amount as verified by the enhanced apatite-forming ability and antibacterial and non-hemolytic properties.

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Acknowledgements

The authors wish to thank the PhD Candidate L. Malletzidou for performing the XRD measurements and Dr T. Zorba for assistance on FTIR measurements.

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Authors and Affiliations

  1. School of Physics, Faculty of Sciences, Aristotle University of Thessaloniki, 54124, Thessaloníki, Greece

    Georgia K. Pouroutzidou, Georgios S. Theodorou, Dimitra Patsiaoura, Christos B. Lioutas, Konstantinos Chrissafis & Konstantinos M. Paraskevopoulos

  2. Department of Fixed Prosthesis and Implant Prosthodontics, School of Health Sciences, Faculty of Dentistry, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece

    Eleana Kontonasaki

  3. Department of Biomedical Sciences, University of Sassari, Sassari, 07100, Italy

    Ioannis Tsamesidis & Antonella Pantaleo

  4. Department of Mineralogy-Petrology-Economic Geology, School of Geology, Faculty of Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece

    Lambrini Papadopoulou

  5. Department of Food Technology, Alexander Technological Educational Institute of Thessaloniki, Thessaloniki, 57 400, Greece

    Jonathan Rhoades & Eleni Likotrafiti

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  1. Georgia K. Pouroutzidou
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Pouroutzidou, G.K., Theodorou, G.S., Kontonasaki, E. et al. Effect of ethanol/TEOS ratios and amount of ammonia on the properties of copper-doped calcium silicate nanoceramics. J Mater Sci: Mater Med 30, 98 (2019). https://doi.org/10.1007/s10856-019-6297-8

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