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Synthesis and Crystal Structure of 4-Methyl-6H-pyrido[3,2,1-jk]carbazol-6-one

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Abstract

The synthesis, NMR and X-ray structure of 4-methyl-6H-pyrido[3,2,1-jk]carbazol-6-one—a potential DNA intercalator are reported. The compound crystallizes in the orthorhombic Pbca space group with unit cell parameters: a = 7.775(8), b = 15.113(7), c = 19.849(7) Å, V = 2332.8(3) Å3, Mr = 233.26 and Z = 8. In the three-dimensional arrangement of the molecules no classical hydrogen bonds were found; weak π···π and C–H···O interactions are responsible for the packing of the molecules in the crystal structure.

Index Abstract

In the three-dimensional arrangement of the title compound no classical hydrogen bonds were found; weak π···π and C–H···O interactions are responsible for the packing of the molecules in the crystal structure.

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Acknowledgment

The authors thank the National Research Fund of Bulgaria for financial support; Grant TK357/TK358/VUH 03/05 VU 986.

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Authors and Affiliations

  1. Department of Structural Biology, University of Pittsburgh, 3501 5-th ave., Pittsburgh, 15260, USA

    Boris Shivachev

  2. Department of Organic Chemistry, Faculty of Chemistry, University of Sofia, 1126, Sofia, Bulgaria

    Petar Petrov

  3. Institute of Organic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Build. 9, 1113, Sofia, Bulgaria

    Malinka Stoyanova

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  1. Boris Shivachev
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  2. Petar Petrov
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  3. Malinka Stoyanova
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Correspondence to Boris Shivachev.

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Shivachev, B., Petrov, P. & Stoyanova, M. Synthesis and Crystal Structure of 4-Methyl-6H-pyrido[3,2,1-jk]carbazol-6-one. J Chem Crystallogr 39, 209–212 (2009). https://doi.org/10.1007/s10870-008-9459-y

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