Skip to main content

Advertisement

Log in

Serum Free Light Chains in CVID—a Marker for Differential Diagnosis

  • Letter to Editor
  • Published:
Journal of Clinical Immunology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abbreviations

AIHA:

Autoimmune hemolytic anemia

CVID:

Common variable immunodeficiency disorder

ESID:

European Society for Immunodeficiencies

GL-ILD:

Granulomatous-lymphocytic interstitial lung disease

Ig:

Immunoglobulin

ITP:

Idiopathic thrombocytopenia

κ:

Kappa

λ:

Lambda

NK cell:

Natural killer cell

NPV:

Negative predictive value

PPV:

Positive predictive value

sFLC:

Serum free light chains

smB:

Switched memory B cell

uAD:

Unclassified antibody deficiency

References

  1. Cunningham-Rundles C. The many faces of common variable immunodeficiency. Hematology Am Soc Hematol Educ Program. 2012;2012:301–5. https://doi.org/10.1182/asheducation-2012.1.301.

    PubMed  PubMed Central  Google Scholar 

  2. Compagno N, Cinetto F, Boscaro E, Semenzato G, Agostini C. Serum free light chains in the differential diagnosis and prognosis of primary and secondary hypogammaglobulinemia. J Allergy Clin Immunol. 2015;135(4):1075–7 e6. https://doi.org/10.1016/j.jaci.2014.10.003.

    Article  CAS  PubMed  Google Scholar 

  3. Sanchez-Ramon S, Radigan L, Yu JE, Bard S, Cunningham-Rundles C. Memory B cells in common variable immunodeficiency: clinical associations and sex differences. Clin Immunol. 2008;128(3):314–21. https://doi.org/10.1016/j.clim.2008.02.013.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Carsetti R, Rosado MM, Donnanno S, Guazzi V, Soresina A, Meini A, et al. The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency. J Allergy Clin Immunol. 2005;115(2):412–7. https://doi.org/10.1016/j.jaci.2004.10.048.

    Article  CAS  PubMed  Google Scholar 

  5. Schussler E, Beasley MB, Maglione PJ. Lung disease in primary antibody deficiencies. J Allergy Clin Immunol Pract. 2016;4(6):1039–52. https://doi.org/10.1016/j.jaip.2016.08.005.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Leif G. Hanitsch.

Ethics declarations

The study was approved by the local ethics committee and patients gave informed consent.

Conflict of Interest

The authors declare that they have no conflicts of interest.

Electronic supplementary material

ESM 1

(PDF 6 kb)

ESM 2

(PDF 15 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hanitsch, L.G., Sotzny, F., Volk, HD. et al. Serum Free Light Chains in CVID—a Marker for Differential Diagnosis. J Clin Immunol 38, 163–165 (2018). https://doi.org/10.1007/s10875-018-0478-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10875-018-0478-y

Navigation