Abbreviations
- AIHA:
-
Autoimmune hemolytic anemia
- CVID:
-
Common variable immunodeficiency disorder
- ESID:
-
European Society for Immunodeficiencies
- GL-ILD:
-
Granulomatous-lymphocytic interstitial lung disease
- Ig:
-
Immunoglobulin
- ITP:
-
Idiopathic thrombocytopenia
- κ:
-
Kappa
- λ:
-
Lambda
- NK cell:
-
Natural killer cell
- NPV:
-
Negative predictive value
- PPV:
-
Positive predictive value
- sFLC:
-
Serum free light chains
- smB:
-
Switched memory B cell
- uAD:
-
Unclassified antibody deficiency
References
Cunningham-Rundles C. The many faces of common variable immunodeficiency. Hematology Am Soc Hematol Educ Program. 2012;2012:301–5. https://doi.org/10.1182/asheducation-2012.1.301.
Compagno N, Cinetto F, Boscaro E, Semenzato G, Agostini C. Serum free light chains in the differential diagnosis and prognosis of primary and secondary hypogammaglobulinemia. J Allergy Clin Immunol. 2015;135(4):1075–7 e6. https://doi.org/10.1016/j.jaci.2014.10.003.
Sanchez-Ramon S, Radigan L, Yu JE, Bard S, Cunningham-Rundles C. Memory B cells in common variable immunodeficiency: clinical associations and sex differences. Clin Immunol. 2008;128(3):314–21. https://doi.org/10.1016/j.clim.2008.02.013.
Carsetti R, Rosado MM, Donnanno S, Guazzi V, Soresina A, Meini A, et al. The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency. J Allergy Clin Immunol. 2005;115(2):412–7. https://doi.org/10.1016/j.jaci.2004.10.048.
Schussler E, Beasley MB, Maglione PJ. Lung disease in primary antibody deficiencies. J Allergy Clin Immunol Pract. 2016;4(6):1039–52. https://doi.org/10.1016/j.jaip.2016.08.005.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The study was approved by the local ethics committee and patients gave informed consent.
Conflict of Interest
The authors declare that they have no conflicts of interest.
Rights and permissions
About this article
Cite this article
Hanitsch, L.G., Sotzny, F., Volk, HD. et al. Serum Free Light Chains in CVID—a Marker for Differential Diagnosis. J Clin Immunol 38, 163–165 (2018). https://doi.org/10.1007/s10875-018-0478-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10875-018-0478-y