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Synthesis, Characterization and Evaluation of Liponiosome Containing Ginger Extract as a New Strategy for Potent Antifungal Formulation

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Abstract

Aflatoxins are natural fungous toxins made by Aspergillus species. The toxins can cause tissue necrosis. In this study, nanoliponiosomes containing ginger extract were synthetized and their antifungal effect on the growth and Aflatoxin production of Aspergillus flavus and Aspergillus parasiticus fungi was studied. Physiochemical characteristics of the sample were determined using XRD, FTIR, AFM, DLS and SEM. The resultant nanostructure can operation as an angiogenesis promoter and provide antifungal nanocarrier for improving the wound healing process. Antifungal activity of ginger extract was determined by disc diffusion and microplate dilution methods. The inhibitory effect of extract on Aflatoxin-B1 production was investigated using MIC method. Ginger concentration, cholesterol%, SPAN-60 and DPPC% were optimized by response surface method. FTIR analysis showed that ginger extract and nanoliponiosome had no chemical interaction resulting in the change of functional groups. SEM observation showed the spherical morphology of particles and the average size of 95 nm. It was also found out that ginger extract had a stronger antifungal effect against Aspergillus flavus fungus compared to Aspergillus parasiticus fungus. The results of this study showed that the ginger extract loaded nanoliponiosomes can be promising antifungal agents for improving wound healing process with high antifungal effects and low side effects.

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Authors and Affiliations

  1. Department of Biotechnology, Tehran North Branch, Islamic Azad University, Tehran, Iran

    Mahya Mohammadi

  2. Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Bibi Fatemeh Haghirosadat & Raheleh Ehsani

  3. Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Bibi Fatemeh Haghirosadat

  4. Department of Biotechnology, Tehran North Branch, Islamic Azad University, Tehran, Iran

    Mohaddeseh larypoor

  5. Department of Life Science Engineering, Faculty of New Science and Technologies, University of Tehran, Tehran, Iran

    Fatemeh Yazdian

  6. Department of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran

    Hamid Rashedi

  7. Young Researchers and Elite Club, Arak Branch, Islamic Azad University, Arak, Iran

    Shabnam Jahanizadeh

  8. Scientific Member and Assistant Professor of Food and Agriculture Faculty, Standard Research Institute (SRI), Standard Square, Karaj, Iran

    Anosheh Rahmani

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  1. Mahya Mohammadi
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Correspondence to Fatemeh Yazdian or Hamid Rashedi.

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Mohammadi, M., Haghirosadat, B.F., larypoor, M. et al. Synthesis, Characterization and Evaluation of Liponiosome Containing Ginger Extract as a New Strategy for Potent Antifungal Formulation. J Clust Sci 31, 971–981 (2020). https://doi.org/10.1007/s10876-019-01702-9

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  • DOI: https://doi.org/10.1007/s10876-019-01702-9

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