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Neurosurgical involvement in clinical trials for CNS tumors

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Abstract

Introduction

Most clinical trials in neurooncology are led by investigators primarily trained in neurology or medical oncology. While neurosurgeons are trained to be problem-solvers and innovators, research training has historically been focused on laboratory-based discovery approaches and formalized training in prospective clinical trials research is not part of routine graduate training.

Methods

We reviewed literature that demonstrates that innovation and problem-solving are integral to the practice of neurosurgery cite multiple examples of advances in technique and technology that may have had an empirical origin but that led to prospective clinical trials resulting in change in practice.

Results

Neurosurgeons have developed and led both traditional (clinical outcome-oriented) and translational prospective clinical trials that have evaluated the best use of currently available therapeutics or tested the ability of novel therapeutics to alter the biology and/or course of disease.

Conclusions

In this review, we focus on a number of the recently developed technologies and therapeutics that were evaluated in clinical trials led or co-led by neurosurgeons. We also highlight some of the barriers that need to be addressed in order to foster neurosurgical participation and leadership in the prospective development of novel therapeutics.

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Authors and Affiliations

  1. Department of NeuroOncology, Moffitt Cancer Center, Tampa, FL, 33612, USA

    Michael A. Vogelbaum

  2. Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA

    Ian F. Parney

  3. Department of Neurosurgery, Ohio State University School of Medicine, Columbus, OH, USA

    J. Bradley Elder

  4. Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA

    Daniel Cahill

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  1. Michael A. Vogelbaum
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Correspondence to Michael A. Vogelbaum.

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Michael A. Vogelbaum has indirect equity and royalty interest in Infuseon Therapeutics and has received honoraria from Celgene and Tocagen. Ian F. Parney has no conflicts to declare. J. Bradley Elder has received honoraria from JNJ, Varian and Medtronic. Daniel P. Cahill has received honoraria and travel reimbursement from Merck, and has served as a consultant for Lilly.

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Vogelbaum, M.A., Parney, I.F., Elder, J.B. et al. Neurosurgical involvement in clinical trials for CNS tumors. J Neurooncol 151, 367–373 (2021). https://doi.org/10.1007/s11060-020-03438-3

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