Skip to main content

Advertisement

SpringerLink
Log in

The Impact of Carotenoids on Immunity (Review)

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

The review covered carotenoids, a large class of natural compounds characterized by a broad spectrum of biological effects, one of which is the ability to influence the immune system. Their mechanisms of action on the human immune system were discussed. The ability of carotenoids to influence both humoral immunity and cellular immunity opens prospects for using these agents in the therapy of a wide range of diseases such as cancer, infectious diseases, neurodegenerative disorders, inflammatory processes, cardiovascular pathology, etc. The latest investigations of the role of carotenoids in gene regulation, apoptosis, and angiogenesis revealed some possible mechanisms of immune system regulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. Bendich, Proc. Nutr. Soc., 50, 263–274 (1991).

    Article  CAS  PubMed  Google Scholar 

  2. C. Lingen, L. Ernster, and O. Lindberg, Exp. Cell Res., 16, 384–393 (1959).

    Article  CAS  PubMed  Google Scholar 

  3. S. N. Meydani, D. Wu, and M. S. Santos, Am. J. Clin. Nutr., 62, 1462–1476 (1995).

    Google Scholar 

  4. S. Gruner, H. D. Volk, and P. Falck, Eur. J. Immunol., 16, 212–215 (1986).

    Article  CAS  PubMed  Google Scholar 

  5. N. Krinsky, Carotenoids in Health and Disease, Dekker, New York (2004), pp. 503–518.

    Google Scholar 

  6. M. K. Shigenaga, T. M. Hagen, and B. N. Ames, Proc. Natl. Acad. Sci. USA, 91, 10771–10778 (1994).

    Article  CAS  PubMed  Google Scholar 

  7. J. S. Park, B. P. Chew, and T. S. Wong, Nutr. Cancer, 33, 206–212 (1999).

    Article  CAS  PubMed  Google Scholar 

  8. C. R. Baskin, K. W. Hinchcliff, and R. A. DiSilvestro, Am. J. Vet. Res., 61, 886–891 (2000).

    Article  CAS  PubMed  Google Scholar 

  9. B. P. Chew, J. S. Park, and B. C. Weng, J. Nutr., 130, 1788–1791 (2000).

    CAS  PubMed  Google Scholar 

  10. J. S. Park, H. W. Kim, and B. D. Mathison, Nutr. Metab., 7, 52–59 (2010).

    Article  Google Scholar 

  11. M. M. Mathews-Roth, Clin. Chem., 24, 700–701 (1978).

    CAS  PubMed  Google Scholar 

  12. B. P. Chew, T. S. Wong, and J. J. Michal, J. Anim. Sci., 71, 730–739 (1993).

    CAS  PubMed  Google Scholar 

  13. B. P. Chew, T. S. Wong, J. J. Michal, et al., J. Anim. Sci., 69(12), 4892–4897 (1991).

    CAS  PubMed  Google Scholar 

  14. B. P. Chew and J. S. Park, J. Nutr., 134, 257–261 (2004).

    Google Scholar 

  15. A. L. Garcia, R. Rihl, and U. Herz, Immunology, 110, 180–187 (2003).

    Article  CAS  PubMed  Google Scholar 

  16. N. Krinsky, Proc. Soc. Exp. Biol. Med., 218, 95–97 (1998).

    Article  CAS  PubMed  Google Scholar 

  17. T. Kobayashi, K. Iijima, and T. Mitamura, Anti-cancer Drugs, 7, 195–198 (1996).

    Article  CAS  PubMed  Google Scholar 

  18. D. A. Hughes, Nutrition, 17, 823–827 (2001).

    Article  CAS  PubMed  Google Scholar 

  19. A. Bendich and S. S. Shapiro, J. Nutr., 116, 2254–2262 (1986).

    CAS  PubMed  Google Scholar 

  20. M. B. Toomey, M. W. Butler, and K. J. McGraw, J. Exp. Biol., 213, 1709–1716 (2010).

    Article  CAS  PubMed  Google Scholar 

  21. T. Sepp, U. Karu, and E. Sild, Exp. Parasitol., 127, No. 3, 651–657 (2011).

    Article  CAS  PubMed  Google Scholar 

  22. P. S. Fitze, B. Tschirren, and J. Gasparini, Am. Nat., 169, 137–144 (2007).

    Article  Google Scholar 

  23. C. D. Hoskinson, B. P. Chew, and T. S. Wong, Biol. Neonate, 62, 325–336 (1992).

    Article  CAS  PubMed  Google Scholar 

  24. L. R. Daniel, B. P. Chew, and T. S. Tanaka, J. Dairy Sci., 74, 124–131 (1991).

    Article  CAS  PubMed  Google Scholar 

  25. G. Van Poppel, S. Spanhaak, and T. Ockhuizen, Am. J. Clin. Nutr., 57, 402–407 (1993).

    PubMed  Google Scholar 

  26. S. Moriguchi, N. Okishima, and S. Sumida, Nutr. Res., 16, 211–218 (1996).

    Article  CAS  Google Scholar 

  27. T. R. Kramer and B. J. Burri, Am. J. Clin. Nutr. 65, 871–875 (1997).

    CAS  PubMed  Google Scholar 

  28. B. P. Chew, J. S. Park, and M. W. Wong, Anticancer Res., 19, 1849–1853 (1999).

    CAS  PubMed  Google Scholar 

  29. W. C. Van Hoorhis, J. Valinski, and E. Hoffman, J. Exp. Med., 158, 174–191 (1983).

    Article  Google Scholar 

  30. G. Y. Kim, J. H. Kim, and S. C. Ahn, Immunology, 113, No. 2, 203–211 (2004).

    Article  CAS  PubMed  Google Scholar 

  31. J. L. Schwartz, E. Flynn, and G. Shklar, Micronutr. Immunol. Function, 587, 92–109 (1990).

    CAS  Google Scholar 

  32. J. J. Michal, B. P. Chew, and T. S. Wong, J. Diary Sci., 77, 1408–1422 (1994).

    Article  CAS  Google Scholar 

  33. W. Zhao, Y. Han, and B. Zhao, Biochim. Biophys. Acta, General Subjects, 1381(1), 77–88 (1998).

    Article  CAS  Google Scholar 

  34. B. P. Chew, J. S. Park, and T. S. Wong, J. Nutr., 130, 1910–1913 (2000).

    CAS  PubMed  Google Scholar 

  35. H. W. Kim, B. P. Chew, and T. S. Wong, Vet. Immunol. Immunopath., 74, 315–327 (2000).

    Article  CAS  Google Scholar 

  36. S. Massimino, R. J. Kearns, and K. M. Loos, J. Vet. Intern. Med., 17, 835–842 (2004).

    Article  Google Scholar 

  37. H. W. Kim, B. P. Chew, and T. S. Wong, Vet. Immunol. Immunopath., 73, 331–341 (2000).

    Article  CAS  Google Scholar 

  38. W. Fawzi, M. G. Herrera, and P. Nestel, J. Nutr., 130, 2537–2542 (2000).

    CAS  PubMed  Google Scholar 

  39. A. Bub, B.Watzl, and L. Abrahamse, J. Nutr., 130, 2200–2206 (2000).

    CAS  PubMed  Google Scholar 

  40. B. Watzl, A. Bub, and K. Briviba, Ann. Nutr. Metab., 47, 255–261 (2003).

    Article  CAS  PubMed  Google Scholar 

  41. B.Watzl, A. Bub, and M. Blockhaus, J. Nutr., 130, 1719–1723 (2000).

    CAS  PubMed  Google Scholar 

  42. M. S. Santos, L. S. Leka, and J. D. Ribaya-Mercado, Am. J. Clin. Nutr., 55, 917–924 (1997).

    Google Scholar 

  43. M. S. Santos, S. N. Meydani, and L. S. Leka, Am. J. Clin. Nutr., 64, 772–777 (1996).

    CAS  PubMed  Google Scholar 

  44. D. Albanes, Am. J. Clin. Nutr., 69, 1345–1350 (1999).

    Google Scholar 

  45. C. N. Holick, D. S. Michaud, and R. Stolzenberg-Solomon, Am. J. Epidemiol., 156, 536–547 (2002).

    Article  PubMed  Google Scholar 

  46. C. L. Rock, L. Natarajan, M. Pu, and C. A. Thomson, Cancer Epidemiol. Biomarkers Prev., 18, 486–494 (2009).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  47. D. S. Michaud, D. Feskanich, and E. B. Rimm, Am. J. Clin. Nutr., 72, 990–997 (2000).

    CAS  PubMed  Google Scholar 

  48. B. L. Pool-Zobel, A. Bub, and H. Muller, Carcinogenesis, 18(9), 1847–1850 (1997).

    Article  CAS  PubMed  Google Scholar 

  49. P. Riso, A. Pinder, and A. Santangelo, Am. J. Clin. Nutr., 69, 712–718 (1999).

    CAS  PubMed  Google Scholar 

  50. J. S. Park, J. H. Chyun, and Y. K. Kim, Nutr. Metab., 7, No. 18, 1–10 (2010).

    Google Scholar 

  51. S. Bhagavathya and P. Sumathib, Asian Pac. J. Trop. Biomed., 2, No. 2, 109–117 (2012).

    Article  Google Scholar 

  52. C. R. Baskin, K. W. Hinchcliff, and R. A. DiSilvestro, Am. J. Vet. Res., 61, 886–891 (2000).

    Article  CAS  PubMed  Google Scholar 

  53. L. A. Herraiz, W. C. Hsieh, and R. S. Parker, J. Am. Coll. Nutr., 17, 617–624 (1998).

    Article  CAS  PubMed  Google Scholar 

  54. C. J. Fuller, H. Faulkner, and A. Bendich, Am. J. Clin. Nutr., 56, 684–690 (1992).

    CAS  PubMed  Google Scholar 

  55. C. Lindholm, M. Quiding-Jarbink, and H. Lonroth, Infect. Immun., 66, 5964–5971 (1998).

    CAS  PubMed Central  PubMed  Google Scholar 

  56. M. Bennedsen, X. Wang, and R. Willen, Immunol. Lett., 70, 185–189 (1999).

    Article  CAS  PubMed  Google Scholar 

  57. H. Van Remmen and A. Richardson, Exp. Gerontol., 36, 957–968 (2001).

    Article  CAS  PubMed  Google Scholar 

  58. S. Massimino, R. J. Kearns, and K. M. Loos, J. Vet. Intern. Med., 17, No. 6, 835–842 (2003).

    Article  PubMed  Google Scholar 

  59. J. M. Van der Horst-Graat, F. J. Kok, and E. G. Schouten, Br. J. Nutr., 92, 113–118 (2004).

    Article  PubMed  Google Scholar 

  60. M. F. Beal, Ann. Neurol., 58(4), 495–505 (2005).

    Article  CAS  PubMed  Google Scholar 

  61. V. H. Perry, C. Cunningham, and D. Boche, Curr. Opin. Neurol., 15, 349–354 (2002).

    Article  PubMed  Google Scholar 

  62. R. P. Copp, T. Wisniewski, and F. Hentati, Brain Res., 822, 80–87 (1999).

    Article  CAS  PubMed  Google Scholar 

  63. J. J. Mitchell, M. Paiva, and M. B. Heaton, Neurosci. Lett., 263, 189–192 (1999).

    Article  CAS  PubMed  Google Scholar 

  64. D. J. Pattison, D. P. M. Symmons, and M. Lunt, Am. J. Clin. Nutr., 82, 451–455 (2005).

    CAS  PubMed  Google Scholar 

  65. J. R. Cerhan, K. J. Saag, L. A. Merlino, T. R. Mikuls, and L. A. Criswell, Am. J. Epidemiol., 157, 345–354 (2003).

    Article  PubMed  Google Scholar 

  66. Y. Tomita, K. Himeno, and K. Nomoto, J. Natl. Cancer Inst., 78, 679–681 (1987).

    CAS  Google Scholar 

  67. P. Prakash, R. M. Russell, and N. I. Krinsky, Nutrition, 131, 1574–1580 (2001).

    CAS  Google Scholar 

  68. H. Jyonouchi, S. Sun, and K. Iijima, Nutr. Cancer, 36(1), 59–65 (2000).

    Article  CAS  PubMed  Google Scholar 

  69. B. P. Chew, M. W. Wong, and T. S. Wong, Anticancer Res., 17, 3689–3694 (1996).

    Google Scholar 

  70. J. S. Park, B. P. Chew, and T. S. Wong, J. Nutr., 128, 1650–1656 (1998).

    CAS  PubMed  Google Scholar 

  71. J. Folkman, Perspect. Biol. Med., 29, 10–36 (1985).

    CAS  PubMed  Google Scholar 

  72. B. P. Chew, C. M. Brown, and J. S. Park, Anticancer Res., 23, 3333–3339 (2003).

    CAS  PubMed  Google Scholar 

  73. J. L. Schwartz and G. Shklar, Nutr. Cancer, 27(2), 192–199 (1997).

    Article  CAS  PubMed  Google Scholar 

  74. C. J. Lacey, M. E. Murphy, and M. J. Sanderson, Int. J. STD AIDS, 7, 485–489 (1996).

    Article  CAS  PubMed  Google Scholar 

  75. R. Ullrich, T. Schneider, and W. Heise, AIDS, 8 661–666 (1994).

    Article  CAS  PubMed  Google Scholar 

  76. A. Metzger, G. Mukasa, and A. H. Shankar, Am. J. Trop. Med. Hyg., 65(2), 115–119 (2001).

    CAS  PubMed  Google Scholar 

  77. G. O. Coodley, H. D. Nelson, and M. O. Loveless, J. Acquired Immune Defic. Syndr., 6, 272–276 (1993).

    CAS  Google Scholar 

  78. A. Bianchi-Santamaria, S. Fedeli, and L. Santamaria, Med. Oncol. Med. Tumor Pharmacother., 9, 151–153 (1992).

    CAS  Google Scholar 

  79. J. Austin, N. Sibghal, and R. Voigt, Eur. J. Clin. Nutr., 60, 1266–1276 (2006).

    Article  CAS  PubMed  Google Scholar 

  80. G. E. Kaugars, S. Silverman, Jr., and G. L. Jonh, Oral Surg. Oral Med. Oral Pathol., 81, 5–14 (1996).

    Article  CAS  Google Scholar 

  81. W. W. Fawzi, G. I. Msamanga, and D. Hunter, AIDS, 16, 1935–1944 (2002).

    Article  CAS  PubMed  Google Scholar 

  82. E. Villamor and W. W. Fawzi, Clin. Microbiol. Rev., 18, 446–464 (2005).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  83. M. L. Watkins, J. D. Erickson, and M. J. Thun, Am. J. Epidemiol., 152, 149–162 (2000).

    Article  CAS  PubMed  Google Scholar 

  84. C. H. Hennekens, J. E. Buring, and J. E. Manson, N. Engl. J. Med., 334(18), 1145–1149 (1996).

    Article  CAS  PubMed  Google Scholar 

  85. G. S. Omenn, G. E. Goodman, and M. D. Thornquist, N. Engl. J. Med., 334, 1150–1155 (1996).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pyatigorsk Institute of Medicine and Pharmacy, Division of Volgograd State Medical University, Pyatigorsk, 357532, Russia

    S. V. Pechinskii & A. G. Kuregyan

Authors
  1. S. V. Pechinskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. G. Kuregyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 10, pp. 3 – 8, October, 2013.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pechinskii, S.V., Kuregyan, A.G. The Impact of Carotenoids on Immunity (Review). Pharm Chem J 47, 509–513 (2014). https://doi.org/10.1007/s11094-014-0992-z

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-014-0992-z

Keywords

Search

Navigation