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Studies of the Hydrolysis of Hesperidin

  • Methods of Drug Synthesis and Drug Production Technology
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Pharmaceutical Chemistry Journal Aims and scope

A variety of hydrolytic mixtures for the cleavage of glycoside bonds in hesperidin was studied. The optimum system for complete hydrolysis of hesperidin to prepare the aglycone consisted of CH3COOH, H2SO4, and C2H5OH at a ratio of 1:1:9. Studies of the kinetics of the hesperidin hydrolysis reaction in this system showed that the process was a first-order reaction, as demonstrated by the constant k. The maximum aglycone yield over time, 98%, was obtained by boiling the reaction mix for 8.5 h. This confirmed the suitability of our model. Prepared of hesperidin-7-O-glucoside should be by fractional hydrolysis in a system consisting of CH3COOH, H2SO4, and C2H5OH at a ratio of 1:1:9.

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Authors and Affiliations

  1. Pyatigorsk Medical-Pharmaceutical Institute at Volgograd State Medical University, Russian Ministry of Health, Pyatigorsk, Russia

    O. S. Evseeva, O. A. Andreeva & É. T. Oganesyan

Authors
  1. O. S. Evseeva
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  2. O. A. Andreeva
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  3. É. T. Oganesyan
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 11, pp. 36 – 39, November, 2013.

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Evseeva, O.S., Andreeva, O.A. & Oganesyan, É.T. Studies of the Hydrolysis of Hesperidin. Pharm Chem J 47, 606–609 (2014). https://doi.org/10.1007/s11094-014-1018-6

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  • DOI: https://doi.org/10.1007/s11094-014-1018-6

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