A series of hydroxy-substituted benzaldehydes and related compounds were synthesized and studied in cell culture against herpes simplex type I (HSV-1) and influenza A (H7N1) viruses. It was found that salicylaldehyde, 2,3-dihydroxybenzaldehyde, and gossypol could suppress HSV-1 replication. The structure–activity relationship of the series of hydroxylated benzaldehydes was analyzed.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 3, pp. 20 – 22, March, 2016.
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Shadyro, O.I., Sorokin, V.L., Ksendzova, G.A. et al. Synthesis and Antiviral Activity of Hydroxy-Substituted Benzaldehydes and Related Compounds. Pharm Chem J 50, 156–158 (2016). https://doi.org/10.1007/s11094-016-1414-1
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DOI: https://doi.org/10.1007/s11094-016-1414-1