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Release Testing of Selected Drugs from Surface Magnetic Nanoparticles and Their Diffusion Through a Membrane

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Pharmaceutical Chemistry Journal Aims and scope

In this study, magnetic nanoparticles were functionalized with dextran and immobilized ibuprofen, diclofenac, and dopamine in order to investigate the diffusion of drugs through a dialysis membrane under biological conditions such as a temperature of 37.0°C and pH 7.4. The concentration of released drugs was measured both inside the membrane and upon release into solution using spectrofluorimetric and spectrophotometric methods. The mechanism of drug release from the carrier was analyzed in terms of the Korsmeyer – Peppas model. The results show that differences in the mechanism of drug release depend on the time-diffusion process and the type of drug used. In addition, the atomic force microscopy and confocal microscopy methods were used to investigate the interaction between bacterial cells and functionalized nanoparticles.

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Acknowledgments

The authors thank Dr. B. Zapotoczny for fruitful discussion of suggestions concerning drug release investigations.

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Authors and Affiliations

  1. Faculty of Biological Sciences, University of Zielona Góra, ul. Szafrana 1, 65 –516, Zielona Góra, Poland

    Ewelina Gronczewska, Andrzej Jurkowski & Jacek J. Kozioł

  2. Innovation Center “Technologies for Human Health”, Science and Technology Park of Zielona Góra University Ltd., ul. Nowy Kisielin - A. Wysockiego 4, 66-002, Zielona Góra, Poland

    Weronika Worobiec, Alicja Defort & Jacek J. Kozioł

Authors
  1. Ewelina Gronczewska
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  2. Weronika Worobiec
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  3. Alicja Defort
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  4. Andrzej Jurkowski
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  5. Jacek J. Kozioł
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Correspondence to Ewelina Gronczewska.

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Gronczewska, E., Worobiec, W., Defort, A. et al. Release Testing of Selected Drugs from Surface Magnetic Nanoparticles and Their Diffusion Through a Membrane. Pharm Chem J 52, 257–265 (2018). https://doi.org/10.1007/s11094-018-1803-8

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  • DOI: https://doi.org/10.1007/s11094-018-1803-8

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