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The efficacy and safety of liraglutide

  • Review Article
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Abstract

Aim of the review To systematically analyze the efficacy and safety of liraglutide for the treatment of diabetes mellitus in comparison to other mono- and combination therapies. Method PubMed (any date) and EMBASE (all years) search was conducted with liraglutide as a search term. Phase III clinical trials retrieved by the two databases and resources posted in Drug@FDA website were evaluated with regard to outcomes of efficacy and safety. Results Eight Phase III clinical studies compared the efficacy and safety of liraglutide to other monotherapies or combinations. Liraglutide as monotherapy in doses of 0.9 mg or above showed a significantly superior reduction in HbA1C compared to monotherapies with glimepiride or glyburide. When liraglutide was used as add-on therapy to glimepiride in doses of 1.2 mg or above, the reduction of HbA1C was greater than that in the combination therapy of glimepiride and rosiglitazone. However, liraglutide as add-on therapy to metformin failed to show benefit over combination of metformin and glimepiride. Triple therapy of using liraglutide in addition to metformin plus either glimepiride or rosiglitazone resulted in additional benefit in HbA1C reduction. Most common adverse events were gastrointestinal disturbance such as nausea, vomit, diarrhea, and constipation. During the eight clinical studies, six cases of pancreatitis and five cases of cancer were reported in liraglutide arm, whereas there was one case of each of pancreatitis in exenatide and glimepiride arms, respectively, and one case of cancer in metformin plus sitagliptin arm. Conclusion Liraglutide is a new therapeutic option to improve glycemic control in patients with type 2 diabetes. However, the present lack of evidence of durability of efficacy and long-term safety appear to limit its utility in the general treatment of type 2 diabetes at this time.

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References

  1. Merani S, Truong W, Emamaullee JA, Toso C, Knudsen LB, Shapiro AM. Liraglutide, a long-acting human glucagon-like peptide 1 analog, improves glucose homeostasis in marginal mass islet transplantation in mice. Endocrinology. 2008;149:4322–8.

    Article  PubMed  CAS  Google Scholar 

  2. Russell-Jones D. Molecular, pharmacological and clinical aspects of liraglutide, a once-daily human GLP-1 analogue. Mol Cell Endocrinol. 2009;297:137–40.

    Article  PubMed  CAS  Google Scholar 

  3. Lin F, Wang R. Molecular modeling of the three-dimensional structure of GLP-1R and its interactions with several agonists. J Mol Model. 2009;15:53–65.

    Article  PubMed  CAS  Google Scholar 

  4. Mari A, Degn K, Brock B, Rungby J, Ferrannini E, Schmitz O. Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions. Diabetes Care. 2007;30:2032–3.

    Article  PubMed  CAS  Google Scholar 

  5. Clinical pharmacology biopharmaceutics review. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022341s000clinpharmr.pdf. Accessed 26 Apr 2011.

  6. Friedrichsen BN, Neubauer N, Lee YC, Gram VK, Blume N, Petersen JS, et al. Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways. J Endocrinol. 2006;188:481–92.

    Article  PubMed  CAS  Google Scholar 

  7. Barnett AH. New treatments in type 2 diabetes: a focus on the incretin-based therapies. Clin Endocrinol (Oxf). 2009;70:343–53.

    Article  CAS  Google Scholar 

  8. Chemistry review. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022341s000chemr.pdf. Accessed 26 Apr 2011.

  9. Irie S, Matsumura Y, Zdravkovic M, Jacobsen LV, Kageyama S. Tolerability, pharmacokinetics and pharmacodynamics of the once-daily human GLP-1 analog liraglutide in Japanese healthy subjects: a randomized, double-blind, placebo-controlled dose-escalation study. Int J Clin Pharmacol Ther. 2008;46:273–9.

    PubMed  CAS  Google Scholar 

  10. Malm-Erjefalt M, Bjørnsdottir I, Vanggaard J, Helleberg H, Larsen U, Oosterhuis B, et al. Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase. Drug Metab Dispos. 2010;38:1944–53.

    Article  PubMed  CAS  Google Scholar 

  11. Meece J. Pharmacokinetics and pharmacodynamics of liraglutide, a long-acting, potent glucagon-like peptide-1 analog. Pharmacotherapy. 2009;29(12 Pt 2):33S–42S.

    Article  PubMed  CAS  Google Scholar 

  12. Grossman S. Differentiating incretin therapies based on structure, activity, and metabolism: focus on liraglutide. Pharmacotherapy. 2009;29(12 Pt 2):25S–32S.

    Article  PubMed  CAS  Google Scholar 

  13. Davidson JA. Incorporating incretin-based therapies into clinical practice: differences between glucagon-like Peptide 1 receptor agonists and dipeptidyl peptidase 4 inhibitors. Mayo Clin Proc. 2010;85(12 Suppl):S27–37.

    Article  PubMed  Google Scholar 

  14. Joffe D. Liraglutide: a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes mellitus. Am J Health Syst Pharm. 2010;67:1326–36.

    Article  PubMed  CAS  Google Scholar 

  15. Tzefos M, Olin JL. Glucagon-like peptide-1 analog and insulin combination therapy in the management of adults with type 2 diabetes mellitus. Ann Pharmacother. 2010;44:1294–300.

    Article  PubMed  CAS  Google Scholar 

  16. Drab SR. Incretin-based therapies for type 2 diabetes mellitus: current status and future prospects. Pharmacotherapy. 2010;30:609–24.

    Article  PubMed  CAS  Google Scholar 

  17. Garber A, Henry R, Ratner R, Garcia-Hernandez PA, Rodriguez-Pattzi H, Olvera-Alvarez I, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet. 2009;373:473–81.

    Article  PubMed  CAS  Google Scholar 

  18. Garber A, Henry RR, Ratner R, Hale P, Chang CT, Bode B, et al. Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes. Diabetes Obes Metab. 2011;13:348–56.

    Article  PubMed  CAS  Google Scholar 

  19. Seino Y, Rasmussen MF, Nishida T, Kaku K. Efficacy and safety of the once-daily human GLP-1 analogue, liraglutide, vs glibenclamide monotherapy in Japanese patients with type 2 diabetes. Curr Med Res Opin. 2010;26:1013–22.

    Article  PubMed  CAS  Google Scholar 

  20. Marre M, Shaw J, Brandle M, Bebakar WM, Kamaruddin NA, Strand J, et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabet Med. 2009;26:268–78.

    Article  PubMed  CAS  Google Scholar 

  21. Nauck M, Frid A, Hermansen K, Shah NS, Tankova T, Mitha IH, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care. 2009;32:84–90.

    Article  PubMed  CAS  Google Scholar 

  22. Pratley RE, Nauck M, Bailey T, Montanya E, Cuddihy R, Filetti S, et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet. 2010;375:1447–56.

    Article  PubMed  CAS  Google Scholar 

  23. Pratley R, Nauck M, Bailey T, Montanya E, Cuddihy R, Filetti S, et al. One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial. Int J Clin Pract. 2011;65:397–407.

    Article  PubMed  CAS  Google Scholar 

  24. Buse JB, Rosenstock J, Sesti G, Schmidt WE, Montanya E, Brett JH, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet. 2009;374:39–47.

    Article  PubMed  CAS  Google Scholar 

  25. Zinman B, Gerich J, Buse JB, Lewin A, Schwartz S, Raskin P, et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met + TZD). Diabetes Care. 2009;32:1224–30.

    Article  PubMed  CAS  Google Scholar 

  26. Russell-Jones D, Vaag A, Schmitz O, Sethi BK, Lalic N, Antic S, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met + SU): a randomised controlled trial. Diabetologia. 2009;52:2046–55.

    Article  PubMed  CAS  Google Scholar 

  27. Pfutzner A, Weber MM, Forst T. A biomarker concept for assessment of insulin resistance, beta-cell function and chronic systemic inflammation in type 2 diabetes mellitus. Clin Lab. 2008;54:485–90.

    PubMed  Google Scholar 

  28. Prescribing information of Victoza. http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022341lbl.pdf. Accessed 26 Apr 2011.

  29. Stirban AO, Tschoepe D. Cardiovascular complications in diabetes: targets and interventions. Diabetes Care. 2008;31(Suppl 2):S215–21.

    Article  PubMed  Google Scholar 

  30. van Dieren S, Beulens JW, van der Schouw YT, Grobbee DE, Neal B. The global burden of diabetes and its complications: an emerging pandemic. Eur J Cardiovasc Prev Rehabil. 2010;17(Suppl 1):S3–8.

    PubMed  Google Scholar 

  31. Nathan DM, Buse JB, Davidson MB, Heine RJ, Holman RR, Sherwin R, et al. Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2006;29:1963–72.

    Article  PubMed  Google Scholar 

  32. International Diabetes Federation. Global guideline for type 2 diabetes. http://www.idf.org/webdata/docs/IDF%20GGT2D.pdf. Accessed 26 Apr 2011.

  33. Rodbard HW, Jellinger PS, Davidson JA, Einhorn D, Garber AJ, Grunberger G, et al. Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. Endocr Pract. 2009;15:540–59.

    PubMed  Google Scholar 

  34. Resnick HE, Foster GL, Bardsley J, Ratner RE. Achievement of American Diabetes Association clinical practice recommendations among US adults with diabetes, 1999–2002: the National Health and Nutrition Examination Survey. Diabetes Care. 2006;29:531–7.

    Article  PubMed  Google Scholar 

  35. Pogach L, Engelgau M, Aron D. Measuring progress toward achieving hemoglobin A1c goals in diabetes care: pass/fail or partial credit. JAMA. 2007;297:520–3.

    Article  PubMed  CAS  Google Scholar 

  36. Redmond EH, Burnett SM, Johnson MA, Park S, Fischer JG, Johnson T. Improvement in A1C levels and diabetes self-management activities following a nutrition and diabetes education program in older adults. J Nutr Elder. 2006;26:83–102.

    Article  PubMed  Google Scholar 

  37. Kothare PA, Linnebjerg H, Isaka Y, Uenaka K, Yamamura A, Yeo KP, et al. Pharmacokinetics, pharmacodynamics, tolerability, and safety of exenatide in Japanese patients with type 2 diabetes mellitus. J Clin Pharmacol. 2008;48:1389–99.

    Article  PubMed  CAS  Google Scholar 

  38. Bjerre Knudsen L, Madsen LW, Andersen S, Almholt K, de Boer AS, Drucker DJ, et al. Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. Endocrinology. 2010;151:1473–86.

    Article  PubMed  Google Scholar 

  39. Pharmacology review. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022341s000pharmr_P1.pdf. Accessed 26 Apr 2011.

  40. Medical review. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022341s000medr_P1.pdf. Accessed 26 Apr 2011.

  41. University of Utah Hospitals & Clinics. New drug bulletin: liraglutide [rDNA origin] injection (Victoza-Novo Nordisk). http://healthcare.utah.edu/pharmacy/bulletins/NDB_213.pdf. Accessed 26 Apr 2011.

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Acknowledgments

The authors would like to thank Dr. Hye-Yoon Choi for her assistance with data collection and analysis for this paper.

Funding

This research was supported by the Yeungnam University research grants in 2010.

Conflicts of interest

The authors have no conflicts of interest to declare.

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  1. Department of Pharmacy Practice, College of Pharmacy, Yeungnam University, Kyungsan, Kyungbuk, 712-749, Korea

    Kyeong-Hye Jeong & Bong Kyu Yoo

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  1. Kyeong-Hye Jeong
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Correspondence to Bong Kyu Yoo.

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Jeong, KH., Yoo, B.K. The efficacy and safety of liraglutide. Int J Clin Pharm 33, 740–749 (2011). https://doi.org/10.1007/s11096-011-9552-8

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