Abstract
Malnutrition—in the form of insufficient energy intakes—affects millions of people worldwide and the negative impact of this kind of hunger is well acknowledged, not least by agronomists trying to increase yields to ensure a sufficient supply of food. This review focuses on another, more particular and “hidden” form of malnutrition, namely mineral malnutrition. It illustrates the burden of disease that is caused by mineral deficiencies and the social and economic consequences they bring about. Mineral malnutrition has a considerable negative impact on individual well-being, social welfare and economic productivity. Agricultural scientists should keep the nutritional qualities of food in mind and—next to optimizing the agricultural properties of crops that are paramount for their adoption by farmers—in particular try to increase the micronutrient content in major staple crops as one way to address vitamin and mineral malnutrition in humans; especially plant breeding approaches promise to be very cost-effective.
Similar content being viewed by others
Notes
The FAO and the WFP differentiate between “malnutrition” (the physical condition resulting from inadequate or unbalanced nutrient intakes or their poor absorption), “undernutrition” (the physical manifestation of prolonged low level food intakes with serious deficiencies in one or a number of macronutrients and micronutrients), “undernourishment” (a situation where people’s food intakes are continuously insufficient to meet their basic energy requirements), “micronutrient deficiency” (lack of essential vitamins and minerals as a result of malnutrition) and, less of relevance in the present context, “overnutrition” (the physical condition resulting from an excess of certain nutrients, which also falls under “malnutrition”) (FAO 1999; WFP 2007). Yet, as the WFP acknowledges, there is some disagreement on what these terms mean and how they relate to each other. Nevertheless, despite being somewhat artificial, such a categorization may offer a relatively clear and consistent way of approaching the issues.
In this context usually also vitamin A deficiency (VAD) is listed, but as the focus of this article is on minerals, vitamin malnutrition is not further considered here.
Even though potassium is an essential mineral (for which e.g. in the USA health claims on foods are permitted), potassium deficiency due to insufficient potassium in the diet is rare and not commonly considered a public health problem; deficiency is rather caused by excessive losses or poor retention.
Stunting can also be an outcome of undernourishment; in cases where undernourishment and ZnD occur in parallel, ZnD increases the prevalence or severity of stunting (Stein et al. 2005).
Other authors suggest that causal relationships may exist between micronutrient deficiencies and obesity in different populations (García et al. 2009).
Abbreviations
- CaD:
-
calcium deficiency
- CGIAR:
-
Consultative Group on International Agricultural Research
- FAO:
-
Food and Agriculture Organization of the United Nations
- FeD:
-
iron deficiency
- FeDA:
-
iron deficiency anemia
- GDP:
-
gross domestic product
- GM:
-
genetically modified
- ID:
-
iodine deficiency
- IPR:
-
intellectual property rights
- SeD:
-
selenium deficiency
- VAD:
-
vitamin A deficiency
- VMD:
-
vitamin and mineral deficiency
- WFP:
-
World Food Programme
- WHO:
-
World Health Organization
- ZnD:
-
zinc deficiency
References
Abdulai A, Aubert D (2004) A cross-section analysis of household demand for food and nutrients in Tanzania. Agr Econ 31:67–79 Also available via http://dx.doi.org/10.1111/j.1574-0862.2004.tb00222.x
ABS (2009) The project. African biofortified sorghum project c/o Africa harvest biotech foundation international, Johannesburg. Available via http://biosorghum.org/project. Accessed 25 June 2009
Adamson P (2004) Vitamin & mineral deficiency: A global progress report. Micronutrient Initiative, Ottawa Available via http://www.micronutrient.org/English/View.asp?x=614. Accessed 4 April 2009
Alderman H, Behrman JR, Ross DR, Sabot R (1996) The returns to endogenous human capital in Pakistan’s rural wage labour market. Oxford Bull Econ Stat 58:30–55 Also available via http://EconPapers.repec.org/RePEc:bla:obuest:v:58:y:1996:i:1:p:29-55
Agronomist (2009) I’m an agronomist: What is agronomy? Iowa State University, Ames Available via http://www.imanagronomist.net/. Accessed 26 June 2009
Allen LH (2003a) Ending hidden hunger: The history of micronutrient deficiency control. In: Gillespie S, McLachlan M, Shrimpton R (eds) Combating malnutrition: Time to act. World Bank, Washington, DC, pp 93–101 Also available via http://go.worldbank.org/VF10E49Q81
Allen LH (2003b) Interventions for micronutrient deficiency control in developing countries: past, present and future. J Nutr 133:3875S–3878S Also available via http://jn.nutrition.org/cgi/content/abstract/133/11/3875S
Allen L, de Benoist B, Dary O, Hurrell R (eds) (2006) Guidelines on food fortification with micronutrients. World Health Organization, Geneva Also available via http://www.who.int/nutrition/publications/micronutrients/
Anderson K, Jackson LA, Nielsen C (2004) Genetically modified rice adoption: Implications for welfare and poverty alleviation. Policy research working paper 3380. World Bank, Washington, DC Also available via http://go.worldbank.org/5Z6GGMKL70
Allgrove J (2004) Is nutritional rickets returning? Arch Dis Child 89:699–701 Also available via http://adc.bmj.com/cgi/content/extract/89/8/699
Arcand J-L (2001) Undernourishment and economic growth: The efficiency cost of hunger. Economic and social development paper no. 147. Food and Agriculture Organization of the United Nations, Rome Also available via http://www.fao.org/DOCREP/003/X9280E/X9280E00.htm
BAGELS (2009) Biofortification through agronomy and genotypes to elevate levels of Selenium. University of Nottingham, Loughborough Available via http://bagels.ukcrop.net/. Accessed 30 September 2009
Baulcombe D, Crute I, Davies B, Dunwell J, Gale M, Jones J, Pretty J, Sutherland W, Toulmin C (2009) Reaping the benefits: Science and the sustainable intensification of global agriculture. The Royal Society, London Also available via http://royalsociety.org/document.asp?tip=0&id=8825
BCP (2009) Mission & objectives. BioCassava Plus Project c/o The Donald Danforth Plant Science Center, St. Louis Available via http://www.biocassavaplus.org/program_description.htm. Accessed 25 June 2009
Behrman JR (1995) Household behaviour and micronutrients: what we know and what we don’t know. Agricultural strategies for micronutrients, working paper 2. International Food Policy Research Institute, Washington, DC Also available via http://www.ifpri.org/pubs/otherpubs.htm#wp
Behrman JR, Deolalikar AB (1987) Will developing country nutrition improve with income? A case study for rural South India. J Polit Econ 95:492–507 Also available via http://www.jstor.org/pss/1831975
Behrman JR, Deolalikar AB (1990) The intrahousehold demand for nutrients in rural south India: individual estimates, fixed effects, and permanent income. J Hum Resour 25(4):665–696 Abstract also available via http://www.ssc.wisc.edu/jhr/1990ab/behrman.html
Behrman JR, Alderman H, Hoddinott J (2004) Hunger and malnutrition. Challenge paper 2004. Copenhagen Consensus, Frederiksberg Available via http://www.copenhagenconsensus.com/Default.aspx?ID=223. Accessed 4 April 2009
Bekaert S, Storozhenko S, Mehrshahi P, Bennett MJ, Lambert W, Gregory JF III, Schubert K, Hugenholtz J, Van Der Straeten D, Hanson AD (2008) Trends Plant Sci 13:28–35 Also available via http://dx.doi.org/10.1016/j.tplants.2007.11.001
Bereket A (2003) Rickets in developing countries. Endocr Dev 6:220–232 Also available via http://dx.doi.org/10.1159/000072778
Bhan MK, Sommerfelt H, Strand T (2001) Micronutrient deficiency in children. Brit J Nutr 85:S199–S203 Also available via http://journals.cambridge.org/action/displayAbstract?aid=891316
Bhutta ZA, Haider BA (2009) CMAJ 180:1188–1189 Also available via http://dx.doi.org/10.1503/cmaj.090652
Biesalski HK, Brummer R-J, König J, O’Connell AA, Ovesen L, Rechkemmer G, Stos K, Thurnham DI (2003) Micronutrient deficiencies: Hohenheim consensus conference. Eur J Nutr 42:353–363 Also available via http://dx.doi.org/10.1007/s00394-003-0460-0
Black RE (2001) Micronutrients in pregnancy. Brit J Nutr 85:S193–S197 Also available via http://journals.cambridge.org/action/displayAbstract?aid=891300
Black RE, Allen LA, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M, Mathers C, Rivera J (2008) Maternal and child undernutrition: global and regional exposures and health consequences. Lancet 371:243–260 Also available via http://dx.doi.org/10.1016/S0140-6736(07)61690-0
Block SA (2002) Nutrition knowledge versus schooling in the demand for child micronutrient status. Working papers in food policy and applied nutrition 10. Tufts University, Boston Also available via http://nutrition.tufts.edu/1184937206715/Nutrition-Page-nl2w_1184937205502.html
Borwankar R, Sanghvi T, Houston R (2007) What is the extent of vitamin and mineral deficiencies? Magnitude of the problem. Food Nutr Bull 28:S174–S181 Also available via http://foodandnutritionbulletin.org/FNB/index.php/FNB/issue/view/138
Bouis HE (ed) (2000) Special issue on improving human nutrition through agriculture. Food Nutr Bull 21: 351–567. Also available via http://www.unu.edu/unupress/food/fnb21-4.pdf (1.6 MB)
Bouis HE, Novenario-Reese MJG (1997) The determinants of demand for micronutrients: An analysis of rural households in Bangladesh. FCND discussion paper 32. International Food Policy Research Institute, Washington, DC Also available via http://www.ifpri.org/divs/FCND/dp/dp32.htm
Broadley MR, White PJ, Bryson RJ, Meacham MC, Bowen HC, Johnson SE, Hawkesford MJ, McGrath SP, Zhao F-J, Breward N, Harriman M, Tucker M (2006) Biofortification of UK food crops with selenium. Proc Nutr Soc 65:169–181 Also available via http://dx.doi.org/10.1079/PNS2006490
Broadley MR, Hammond JP, King GJ, Bowen HC, Hayden R, Spracklen WP, Lochlainn SO, White PJ (2009) Biofortifying Brassica with calcium (Ca) and magnesium (Mg). Proceedings of the International Plant Nutrition Colloquium XVI, September 15, Paper 1256. Also available via http://repositories.cdlib.org/ipnc/xvi/1256
Broca S, Stamoulis K (2003) Micro- and macroevidence on the impact of undernourishment. In: Taniguchi K, Wang X (eds) Nutrition intake and economic growth. Food and Agriculture Organization of the United Nations, Rome Also available via http://www.fao.org/docrep/006/y4850e/y4850e00.htm
Cairns G (2005) Food biotechnology and consumer perceptions in Asia. Food Nutr Bull 26:443–444 Also available via http://www.unu.edu/unupress/food/unupress.htm#2005, Volume 26, number 4
Cakmak I (2008) Enrichment of cereal grains with zinc: agronomic or genetic biofortification? Plant Soil 302:1–17 Also available via http://dx.doi.org/10.1007/s11104-007-9466-3
Cakmak I (2009a) Enrichment of fertilizers with zinc: an excellent investment for humanity and crop production in India. J Trace Elem Med Biol 23:281–289 Also available via http://dx.doi.org/10.1016/j.jtemb.2009.05.002
Cakmak I (2009b) Agronomic approaches in biofortification of food crops with micronutrients. Proceedings of the International Plant Nutrition Colloquium XVI, Paper 1451. Available via http://repositories.cdlib.org/ipnc/xvi/1451. Accessed 18 September 2009
Cakmak I, Ozkan H, Braun HJ, Welch RM, Romheld V (2000) Zinc and iron concentrations in seeds of wild, primitive, and modern wheats. Food Nutr Bull 21:401–403 Also available via http://foodandnutritionbulletin.org/FNB/index.php/FNB/article/view/276
Chernichovsky D, Meesook OA (1984) Patterns of food consumption and nutrition in Indonesia: an analysis of the national socioeconomic survey, 1978. Staff working paper 670. World Bank, Washington, DC Also available via http://go.worldbank.org/QNBRY2APZ3
Chong M (2003) Acceptance of Golden Rice in the Philippine ‘rice bowl’. Nat Biotechnol 21:971–972 Also available via http://dx.doi.org/10.1038/nbt0903-971
Chowdhury S, Meenakshi JV, Tomlins K, Owori C (2009) Are consumers willing to pay more for biofortified foods? Evidence from a field experiment in Uganda. HarvestPlus working paper 3. International Food Policy Research Institute, Washington Also available via http://www.harvestplus.org/content/are-consumers-willing-pay-more-biofortified-foods-evidence-field-experiment-uganda
CIAT/IFPRI (2002) Biofortified crops for improved human nutrition. A challenge program proposal. Consultative Group on International Agricultural Research, Washington http://www.cgiar.org/pdf/biofortification.pdf (767 KB)
Cohen JI, Paarlberg R (2002) Explaining restricted approval and availability of GM crops in developing countries. AgBiotechNet 4:1–6 Also available via http://www.joelcohen.org/publications.html#biosafety
Combs GF (2001) Selenium in global food systems. Br J Nutr 85:517–547 Also available via http://dx.doi.org/10.1079/BJN2000280
Connolly EL (2008) Raising the bar for biofortification: enhanced levels of bioavailable calcium in carrots. Trends Biotechnol 26:401–403 Also available via http://dx.doi.org/10.1016/j.tibtech.2008.04.007
de Benoist B, Andersson M, Egli I, Takkouche B, Allen H (eds) (2004) Iodine status worldwide: WHO global database on iodine deficiency. World Health Organization, Geneva Also available via http://www.who.int/vmnis/iodine/status/
de Benoist B, McLean E, Egli I, Cogswell M (2008) Worldwide prevalence of anaemia 1993–2005: WHO global database on anaemia. World Health Organization, Geneva Also available via http://www.who.int/vmnis/anaemia/prevalence/
De Groote H, Chege Kimenju S (2008) Comparing consumer preferences for color and nutritional quality in maize: application of a semi-double-bound logistic model on urban consumers in Kenya. Food Policy 33:362–370 Also available via http://dx.doi.org/10.1016/j.foodpol.2008.02.005
Delmer DP, Nottenburg C, Graff GD, Bennett AB (2003) Intellectual property resources for international development in agriculture. Plant Physiol 133:1666–1670 Also available via http://www.plantphysiol.org/cgi/content/short/133/4/1666
DeLucia MC, Mitnick ME, Carpenter TO (2003) Nutritional rickets with normal circulating 25-hydroxyvitamin D: a call for reexamining the role of dietary calcium intake in North American infants. J Clin Endocrinol Metab 88:3539–3545 Also available via http://jcem.endojournals.org/cgi/content/abstract/88/8/3539
Deolalikar AB (1988) Nutrition and labor productivity in agriculture: estimates for rural South India. Rev Econ Stat 70:406–13 Also available via http://EconPapers.repec.org/RePEc:tpr:restat:v:70:y:1988:i:3:p:406-13
Dickinson N, Macpherson G, Hursthouse AS, Atkinson J (2009) Micronutrient deficiencies in maternity and child health: a review of environmental and social context and implications for Malawi. Environ Geochem Health 31:253–272 Also available via http://dx.doi.org/10.1007/s10653-008-9207-4
Ezzati M, Lopez AD, Rodgers A, Murray CJL (eds) (2004) Comparative quantification of health risks: Global and regional burden of diseases attributable to selected major risk factors. World Health Organization, Geneva Also available via http://www.who.int/healthinfo/global_burden_disease/cra/
FAO (1999) The state of food insecurity in the world 1999. Food and Agriculture Organization of the United Nations, Rome Also available via http://www.fao.org/publications/sofi/en/
FAO (2001) Targeting for nutrition improvement: Resources for advancing nutritional well-being. Chapter 5: types of targeted food and nutrition programmes. Food and Agriculture Organization of the United Nations, Rome, pp 63–72 Also available via http://www.fao.org/DOCREP/004/Y1329E/y1329e00.htm
FAO (2004) The state of food insecurity in the world 2004. Food and Agriculture Organization of the United Nations, Rome Also available via http://www.fao.org/publications/sofi/en/
FAO (2006) The double burden of malnutrition: Case studies from six developing countries. Food and Agriculture Organization of the United Nations, Rome Also available via http://www.fao.org/docrep/009/a0442e/a0442e00.htm
FAO (2008a) The state of food insecurity in the world 2008. Food and Agriculture Organization of the United Nations, Rome Also available via http://www.fao.org/SOF/sofi/
FAO (2008b) Hunger on the rise. News Story, 18 September. Food and Agriculture Organization of the United Nations, Rome Available via http://www.fao.org/newsroom/en/news/2008/1000923/. Accessed 4 April 2009
FAO (2009) The state of food insecurity in the world 2009. Food and Agriculture Organization of the United Nations, Rome Also available via http://www.fao.org/publications/sofi/en/
Fogel RW (2004) The escape from hunger and premature death, 1700–2100: Europe, America, and the Third World. Cambridge University Press, Cambridge Also available via http://www.cambridge.org/us/catalogue/catalogue.asp?isbn=9780511206979
G-20 (2009) Global plan for recovery and reform. Official communiqué of the Group of Twenty (G-20) finance ministers and central bank governors. London Summit, London Available via http://www.londonsummit.gov.uk/resources/en/news/15766232/communique-020409. Accessed 4 April 2009
GAIN (2009) Vitamin and mineral deficiencies technical situation analysis: Ten year strategy for the reduction of vitamin and mineral deficiencies. Global Alliance for Improved Nutrition, Geneva Also available via http://www.gainhealth.org/reports/ten-year-strategy-vitamin-and-mineral-deficiencies-technical-situation-analysis
García OP, Long KZ, Rosado JL (2009) Impact of micronutrient deficiencies on obesity. Nutr Rev 67:559–572 Also available via http://www3.interscience.wiley.com/journal/122608371/abstract
GCGH (2009) Optimisation of bioavailable nutrients in transgenic bananas. Grand Challenges in Global Health c/o Bill & Melinda Gates Foundation, Seattle Available via http://www.gcgh.org/ImproveNutrition/Challenges/NutrientRichPlants/Pages/Bananas.aspx. Accessed 25 June 2009
GR (2009) Grand challenges in global health project. Golden Rice Project c/o University of Freiburg, Freiburg Available via http://www.goldenrice.org/Content5-GCGH/GCGH1.html. Accessed 25 June 2009
Graham R, Senadhira D, Beebe S, Iglesias C, Monasterio I (1999) Breeding for micronutrient density in edible portions of staple food crops: conventional approaches. Field Crops Res 60:57–80 Also available via http://dx.doi.org/10.1016/S0378-4290(98)00133-6
Graham RD, Welch RM, Bouis HE (2001) Addressing micronutrient malnutrition through enhancing the nutritional quality of staple foods: principles, perspectives and knowledge gaps. Adv Agron 70:77–142 Also available via http://www.elsevier.com/wps/find/bookdescription.cws_home/675475/description
Haas JD, Brownlie T (2001) Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr 131:676S–690S Also available via http://jn.nutrition.org/cgi/content/abstract/131/2/676S
Haas JD, Beard JL, Murray-Kolb LE, del Mundo AM, Felix AR, Gregorio GB (2005) Iron-biofortified rice improves iron stores in non-anemic Filipino women. J Nutr 135:2823–2830 Also available via http://jn.nutrition.org/cgi/content/abstract/135/12/2823
Haddad LJ, Bouis HE (1991) The impact of nutritional status on agricultural productivity: wage evidence from the Philippines. Oxford Bull Econ Stat 53:45–68 Also available via http://EconPapers.repec.org/RePEc:bla:obuest:v:53:y:1991:i:1:p:45-68
Haddad L, Alderman H, Appleton S, Song L, Yohannes Y (2003) Reducing child malnutrition: how far does income growth take us? World Bank Econ Rev 17:107–131 Also available via http://wber.oxfordjournals.org/cgi/content/abstract/17/1/107
Hagenimana V, Low J (2000) Potential of orange-fleshed sweet potatoes for raising vitamin A intake in Africa. Food Nutr Bull 21:414–418 Also available via http://www.unu.edu/unupress/food/unupress.htm#2000, Volume 21, number 4
HarvestPlus (2009) Target countries and crops. Web page of HarvestPlus, International Food Policy Research Institute, Washington, DC Available via http://www.harvestplus.org/content/target-countries-and-crops. Accessed 25 June 2009
HarvestZinc (2009) HarvestZinc fertilizer project. Web page of HarvestZinc, Sabanci University, Istanbul Available via http://www.harvestzinc.org/. Accessed 26 October 2009
Heaney RP (2003) Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr 78:912–919 Also available via http://www.ajcn.org/cgi/content/abstract/78/5/912
Heyd H (2007) Food consumption, micronutrient malnutrition and the potential of orange-fleshed sweet potatoes in Uganda. Universität Hohenheim, Stuttgart
Horton S, Ross J (2003) The economics of iron deficiency. Food Policy 28:51–75 Also available via http://dx.doi.org/10.1016/S0306-9192(02)00070-2
Horton S, Alderman H, Rivera JA (2008) Hunger and malnutrition. Challenge paper 2008. Copenhagen Consensus, Frederiksberg Available via http://www.copenhagenconsensus.com/Default.aspx?ID=1149. Accessed 28 February 2009
Hotz C, Brown KH (eds) (2004) Assessment of the risk of zinc deficiency in populations and options for its control. International Zinc Nutrition Consultative Group Technical Document No. 1, Food Nutr Bull 25: S91–S204. Also available via http://www.izincg.org/technical.php
INSTAPA (2009) Novel staple food-based strategies to improve micronutrient status for better health and development in sub-Saharan Africa. Web page of INSTAPA, Wageningen University, Wageningen Available via http://www.instapa.org/. Accessed 27 October 2009
IOM (2001) Dietary reference intakes: Elements. Overview table of the Institute of Medicine of the National Academies, Washington, DC Available via http://www.iom.edu/CMS/54133/54377/54395.aspx. Accessed 1 March 2009
IOM (2004) Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Institute of Medicine, National Academies, Washington, DC Also available via http://www.nap.edu/catalog.php?record_id=10925
Jha R, Gaiha R, Sharma A (2009) Calorie and micronutrient deprivation and poverty nutrition traps in rural India. World Dev 37:982–991 Also available via http://dx.doi.org/10.1016/j.worlddev.2008.09.008
JN (2009) Nutrient information. Web page of The Journal of Nutrition, American Society for Nutrition, Bethesda Available via http://jn.nutrition.org/nutinfo/. Accessed 1 March 2009
Kandpal E, McNamara PE (2009) Determinants of nutritional outcomes of children in India: A quantile regression approach. Selected Paper, Annual Meeting of the Agricultural and Applied Economics Association, July 26–28, Milwaukee, WI. AgEcon Search, St. Paul, MN Also available via http://purl.umn.edu/49415
Kennedy G, Natel G, Shetty P (2003a) The scourge of ‘hidden hunger’: global dimensions of micronutrient deficiencies. Food Nutr Agric 32:8–16 Also available via http://www.fao.org/DOCREP/005/Y8346M/y8346m02.htm
Kennedy E, Mannar V, Iyengar V (2003b) Alleviating hidden hunger: approaches that work. IAEA Bulletin 45:54–60 Also available via http://www.iaea.org/Publications/Magazines/Bulletin/Bull451/
Khoshgoftarmanesh AH, Schulin R, Chaney RL, Daneshbakhsh B, Afyuni M (2009) Micronutrient-efficient genotypes for crop yield and nutritional quality in sustainable agriculture. A review. Agron Sustain Dev, published online 25 June. Also available via http://dx.doi.org/10.1051/agro/2009017
Kryder RD, Kowalski SP, Krattiger AF (2000) The intellectual and technical property components of pro-vitamin A rice (Golden Rice): A preliminary freedom-to-operate review. ISAAA Brief 20. International Service for the Acquisition of Agri-biotech Applications, Ithaca Also available via http://www.isaaa.org/resources/publications/briefs/20/
Kwun I-S, Do M-S, Chung H-R, Kim Yh, Beattie JH (2009) The impact of rapid economic growth and globalization on zinc nutrition in South Korea. Public Health Nutr 12:1234–1241 Also available via http://dx.doi.org/10.1017/S1368980008003789
Leibenstein H (1957) The theory of underemployment in backward economies. J Polit Econ 65:91–103 Also available via http://dx.doi.org/10.1086/257894
Liu Y, Shankar B (2006) A panel data study of the determinants of micronutrient intake in China. Contributed paper, 26th conference of the international association of agricultural economists, August 12–18, Broadbeach. AgEcon Search, St. Paul. http://purl.umn.edu/25585
Low JW, Low JW, Arimond M, Osman N, Cunguara B, Zano F, Tschirley D (2007) A food-based approach introducing orange-fleshed sweet potatoes increased vitamin A intake and serum retinol concentrations in young children in rural Mozambique. J Nutr 137:1320–1327 Also available via http://jn.nutrition.org/cgi/content/abstract/137/5/1320
Ma G, Jin Y, Li Y, Zhai F, Kok FJ, Jacobsen E, Yang X (2008) Iron and zinc deficiencies in China: what is a feasible and cost-effective strategy? Public Health Nutr 11:632–638 Also available via http://dx.doi.org/10.1017/S1368980007001085
Mahendra Dev S (2003) Right to food in India. Working paper 50. Centre for Economic and Social Studies, Hyderabad Also available via http://www.cess.ac.in/cesshome/workingpaperoff.htm
Martínez-Ballesta MC, Dominguez-Perles R, Moreno DA, Muries B, Alcaraz-López C, Bastías E, García-Viguera C, Carvajal M (2009) Minerals in plant food: effect of agricultural practices and role in human health. A review. Agron Sustain Dev, online 6 August. Also available via http://dx.doi.org/10.1051/agro/2009022
Mazuze FM (2007) Analysis of adoption of orange-fleshed sweetpotatoes: The case study of Gaza Province in Mozambique. Research report 4E. Michigan State University, East Lansing Also available via http://www.aec.msu.edu/fs2/mozambique/iiam/rr_4e.pdf (187 KB)
Meenakshi JV, Johnson N, Manyong VM, De Groote H, Javelosa J, Yanggen D, Naher F, Gonzalez C, Garcia J, Meng E (2009) How cost-effective is biofortification in combating micronutrient malnutrition? An ex-ante assessment. World Dev, in press. Also available via http://dx.doi.org/10.1016/j.worlddev.2009.03.014
MI (2009) What is hidden hunger? Web page of the micronutrient initiative, Ottawa Available via http://www.micronutrient.org/english/View.asp?x=573. Accessed 28 February 2009
MI/UNICEF (2004) Vitamin and mineral deficiency: A global progress report. The Micronutrient Initiative, Ottawa Also available via http://www.micronutrient.org/English/View.asp?x=614
Monasterio I, Graham RD (2000) Breeding for trace minerals in wheat. Food Nutr Bull 21:392–396 Also available via http://foodandnutritionbulletin.org/FNB/index.php/FNB/article/view/304
Murray CJL, Lopez AD (eds) (1996) The global burden of disease. Global burden of disease and injury series, Vol. 1. Harvard University, Cambridge Also available via http://www.hup.harvard.edu/catalog/MURGLO.html
Muzhingi T, Langyintuo AS, Malaba LC, Banziger M (2008) Consumer acceptability of yellow maize products in Zimbabwe. Food Policy 33:352–36 Also available via http://dx.doi.org/10.1016/j.foodpol.2007.09.003
Nestel P, Bouis HE, Meenakshi JV, Pfeiffer W (2006) Biofortification of staple food crops. J Nutr 136:1064–1067 Also available via http://jn.nutrition.org/cgi/content/abstract/136/4/1064
Nicklas TA (2003) Calcium intake trends and health consequences from childhood through adulthood. J Am Coll Nutr 22:340–356 Also available via http://www.jacn.org/cgi/content/abstract/22/5/340
Nieves JW (2005) Osteoporosis: the role of micronutrients. Am J Clin Nutr 81:1232S–1239S Also available via http://www.ajcn.org/cgi/content/abstract/81/5/1232S
Paarlberg R (2006) Are genetically modified (GM) crops a commercial risk for Africa? Int J Tech Global 2:81–92 Also available via http://www.ingentaconnect.com/content/ind/ijtg/2006/00000002/F0020001/art00011
Park S, Elless MP, Park J, Jenkins A, Lim W, Chambers E IV, Hirschi KD (2009) Sensory analysis of calcium-biofortified lettuce. Plant Biotech J 7:106–117. Also available via http://dx.doi.org/10.1111/j.1467-7652.2008.00379.x
Palmgren MB, Clemens S, Williams LE, Krämer U, Borg S, Schjørring JK, Sanders D (2008) Zinc biofortification of cereals: problems and solutions. Trends Plant Sci 13:464–473 Also available via http://dx.doi.org/10.1016/j.tplants.2008.06.005
Pettifor JM (2004) Nutritional rickets: deficiency of vitamin D, calcium, or both? Am J Clin Nutr 80:1725S–1729S Also available via http://www.ajcn.org/cgi/content/abstract/80/6/1725S
Pitt MM (1983) Food preferences and nutrition in rural Bangladesh. Rev Econ Stat 65:105–114 Also available via http://www.jstor.org/stable/1924414
Pittas AG, Lau J, Hu FB, Dawson-Hughes B (2007) The role of vitamin D and calcium in type 2 diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab 92:2017–2029 Also available via http://dx.doi.org/10.1210/jc.2007-0298
Popkin BM (2001) The nutrition transition and obesity in the developing world. J Nutr 131:S871–S873 Also available via http://jn.nutrition.org/cgi/content/abstract/131/3/871S
Popkin BM, Horton S, Kim S, Mahal A, Shuigao J (2001) Trends in diet, nutritional status, and diet-related noncommunicable diseases in China and India: the economic costs of the nutrition transition. Nutr Rev 59:379–390 Also available via http://www3.interscience.wiley.com/journal/121482696/abstract
Potrykus I (2009) Lessons from Golden Rice on public sector responsibility and failure. New Biotechnol 25:S321–S322 Also available via http://dx.doi.org/10.1016/j.nbt.2009.06.542
Pray C, Huang J (2007) Biofortification for China: political responses to food fortification and GM technology, interest groups, and possible strategies. AgBioForum 10:161–169 Also available via http://www.agbioforum.org/v10n3/v10n3a05-pray.htm
Pray C, Paarlberg R, Unnevehr L (2007) Patterns of political response to biofortified varieties of crops produced with different breeding techniques and agronomic traits. AgBioForum 10:135–143 Also available via http://www.agbioforum.org/v10n3/v10n3a02-pray.htm
Qaim M, Stein AJ (2009) Biofortification of staple crops: how well does it work and what does it cost? Ernähr Um 56:274–280 Also available via http://www.ernaehrungs-umschau.de/archiv/summaries/?id=3858
Qaim M, Stein AJ, Meenakshi JV (2007) Economics of biofortification. Agr Econ 37:S119–S133 Also available via http://www3.interscience.wiley.com/journal/117962879/abstract
Ramakrishnan U, Yip R (2002) Experiences and challenges in industrialized countries: control of iron deficiency in industrialized countries. J Nutr 132:S820–S824 Also available via http://jn.nutrition.org/cgi/content/abstract/132/4/820S
Rayman MP (2008) Food-chain selenium and human health: emphasis on intake. Brit J Nutr 100:254–268 Also available via http://dx.doi.org/10.1017/S0007114508939830
Reuters (2009) EU rejects more U.S. soy with GM corn traces. News article, September 18. Thomson Reuters, New York. Available via http://www.reuters.com/article/companyNews/idUKTRE58H4GG20090918. Accessed 12 Oct 2009
Ríos JJ, Rosales MA, Blasco B, Cervilla LM, Romero L, Ruiz JM (2008) Biofortification of Se and induction of the antioxidant capacity in lettuce plants. Sci Hortic-Amsterdam 116:248–25. Also available via http://dx.doi.org/doi:10.1016/j.scienta.2008.01.008
Rosado JL, Hambidge KM, Miller LV, Garcia OP, Westcott J, Gonzalez K, Conde J, Hotz C, Pfeiffer W, Ortiz-Monasterio I, Krebs NF (2009) The quantity of zinc absorbed from wheat in adult women is enhanced by biofortification. J Nutr 139:1920–1925 Also available via http://dx.doi.org/10.3945/jn.109.107755
Ruel MT (2001) Can food-based strategies help reduce vitamin A and iron deficiencies? A review of recent evidence. International Food Policy Research Institute, Washington, DC. Also available via http://www.ifpri.org/pubs/fpreview/fpreview05.htm
Ruel MT (2003) Is dietary diversity an indicator for food security or dietary quality? A review of measurement issues and research needs. International Food Policy Research Institute, Washington, DC Also available via http://www.ifpri.org/publication/dietary-diversity-indicator-food-security-or-dietary-quality
Sanchez PA, Swaminathan MS, Dobie P, Yuksel N (2005) Halving hunger: It can be done. UN Millennium Project, Earthscan, London Also available via http://www.unmillenniumproject.org/reports/tf_hunger.htm
Smith LC, Haddad L (2000) Explaining child malnutrition in developing countries: A cross-country analysis. Research Report 111, International Food Policy Research Institute, Washington DC Also available via http://www.ifpri.org/pubs/abstract/abstr111.htm
Stein A (2006) Micronutrient malnutrition and the impact of modern plant breeding on public health in India: How cost-effective is biofortification? Cuvillier Verlag, Göttingen Also available via http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:bsz:100-opus-1574
Stein AJ, Qaim M (2007) The human and economic cost of hidden hunger. Food Nutr Bull 28:125–134 Also available via http://foodandnutritionbulletin.org/FNB/index.php/FNB/article/view/1841
Stein AJ, Meenakshi JV, Qaim M, Nestel P, Sachdev HPS, Bhutta ZA (2005) Analyzing the health benefits of biofortified staple crops by means of the disability-adjusted life years approach: A handbook focusing on iron, zinc and vitamin A. HarvestPlus Technical Monograph 4, International Food Policy Research Institute, Washington DC Also available via http://www.harvestplus.org/publications/13
Stein AJ, Sachdev HPS, Qaim M (2006) Potential impact and cost-effectiveness of Golden Rice. Nat Biotechnol 24:1200–1201 Also available via http://dx.doi.org/10.1038/nbt1006-1200b
Stein AJ, Nestel P, Meenakshi JV, Qaim M, Sachdev HPS, Bhutta ZA (2007) Plant breeding to control zinc deficiency in India: how cost-effective is biofortification? Public Health Nutr 10:492–501 Also available via http://dx.doi.org/10.1017/S1368980007223857
Stein AJ, Meenakshi JV, Qaim M, Nestel P, Sachdev HPS, Bhutta ZA (2008a) Potential impacts of iron biofortification in India. Soc Sci Med 66:1659–1870 Also available via http://dx.doi.org/:10.1016/j.socscimed.2008.01.006
Stein AJ, Sachdev HPS, Qaim M (2008b) Genetic engineering for the poor: Golden Rice and public health in India. World Dev 36:144–158 Also available via http://dx.doi.org/10.1016/j.worlddev.2007.02.013
Stein AJ, Qaim M, Nestel P (2009) Zinc deficiency and DALYs in India: Impact assessment and economic analyses. In: Preedy V, Watson RR (eds) Handbook of disease burdens and quality of life measures. Springer, Heidelberg Also available via http://www.springer.com/medicine/book/978-0-387-78665-0
Stevens R, Winter-Nelson A (2008) Consumer acceptance of provitamin A-biofortified maize in Maputo, Mozambique. Food Policy 33:341–351 Also available via http://dx.doi.org/10.1016/j.foodpol.2007.12.003
Stomph TJ, Jiang W, Struik PC (2009) Zinc biofortification of cereals: rice differs from wheat and barley. Trends Plant Sci 14:123–124 Also available via http://dx.doi.org/10.1016/j.tplants.2009.01.001
Strauss J (1986) Does better nutrition raise farm productivity? J Polit Econ 94:297–320 Also available via http://dx.doi.org/10.1086/261375
Strauss J, Thomas D (1998) Health, nutrition, and economic development. J Econ Lit 36:766–817 Also available via http://www.aeaweb.org/journal/contents/june1998.html
Tang G, Qin J, Dolnikowski GG, Russell RM, Grusak MA (2009) Golden Rice is an effective source of vitamin A. Am J Clin Nutr 89:1776–1783 Also available via http://dx.doi.org/10.3945/ajcn.2008.27119
Thacher TD, Fischer PR, Strand MA, Pettifor JM (2006) Nutritional rickets around the world: causes and future directions. Ann Trop Paediatr Int Child Health 26:1–16 Also available via http://www.ingentaconnect.com/content/maney/atp/2006/00000026/00000001/art00001
Thinley LJY (1999) Values and development: “Gross national happiness”. Keynote speech delivered at the Millennium Meeting for Asia and the Pacific, Seoul. In: Kinga S, Galay K, Rapten P, Pain A (eds) Gross national happiness: A set of discussion papers. Centre for Bhutan Studies, Thimpbu, pp 12–23 Available via http://www.bhutanstudies.org.bt/main/pub_detail.php?pubid=65. Accessed 4 April 2009
UN (1999) The right to adequate food. E/C.12/1999/5. Committee on economic, social and cultural rights, twentieth session. United Nations, Economic and Social Council, Geneva Available via http://www.unhchr.ch/tbs/doc.nsf/0/3d02758c707031d58025677f003b73b9. Accessed 28 February 2009
UN (2000) United Nations millennium declaration. General assembly resolution 55/2, 8 September, 2000th edn. United Nations, New York Available via http://www.un.org/millennium/declaration/ares552e.htm. Accessed 4 April 2009
Underwood BA, Smitasiri S (1999) Micronutrient malnutrition: policies and programs for control and their implications. Annu Rev Nutr 19:303–324 Also available via http://dx.doi.org/10.1146/annurev.nutr.19.1.303
UNDP (2009) The human development concept. Web page of the human development report office. United Nations Development Programme, New York Available via http://hdr.undp.org/en/humandev/. Accessed 4 April 2009
Wang X, Taniguchi K (2003) Does better nutrition enhance economic growth? The economic cost of hunger. In: Taniguchi K, Wang X (eds) Nutrition intake and economic growth. Food and Agriculture Organization of the United Nations, Rome Also available via http://www.fao.org/docrep/006/y4850e/y4850e00.htm
Ward JO, Sanders JH (1980) Nutritional determinants and migration in the Brazilian northeast: a case study of rural and urban Ceara. Econ Dev Cult Change 29:141–163 Also available via http://dx.doi.org/10.1086/451235
Webb P, Block S (2003) Nutrition knowledge and parental schooling as inputs to child nutrition in the long and short run. Working papers in food policy and applied nutrition 21. Tufts University, Boston http://nutrition.tufts.edu/1184937206715/Nutrition-Page-nl2w_1184937205502.html
Weinberger K (2003) The impact of micronutrients on labor productivity: evidence from rural India. Contributed paper, annual meeting, August 16–22. International Association of Agricultural Economists, Durban Available via http://purl.umn.edu/25897. Accessed 4 April 2009
Welch RM, Bouis HE (2009) Biofortification—a sustainable agricultural strategy for reducing micronutrient malnutrition in the Global South. Science Forum, 16–17 June, Wageningen. Also available via http://www.scienceforum2009.nl/Portals/11/2WelchBouisBiofortification.pdf (319 KB)
Welch RM, Graham RD (2000) A new paradigm for world agriculture: productive, sustainable, nutritious, healthful food systems. Food Nutr Bull 21:361–366 Also available via http://foodandnutritionbulletin.org/FNB/index.php/FNB/article/view/322
Welch RM, Graham RD (2002) Breeding crops for enhanced micronutrient content. Plant Soil 245:205–214 Also available via http://www.ingentaconnect.com/content/klu/plso/2002/00000245/00000001/00312890
WFP (2007) Hunger and health. World hunger series 2007. World Food Programme. Earthscan, London Also available via http://wfp.org/policies/introduction/other/
White PJ, Bradshaw JE, Finlay M, Dale B, Ramsay G, Hammond JP, Broadley MR (2009) Relationships between yield and mineral concentrations in potato tubers. HortSci 44:6–11 Also available via http://hortsci.ashspublications.org/cgi/content/abstract/44/1/6
White PJ, Broadley MR (2005) Biofortifying crops with essential mineral elements. Trends Plant Sci 10:586–593 Also available via http://dx.doi.org/10.1016/j.tplants.2005.10.001
White PJ, Broadley MR (2009) Biofortification of crops with seven mineral elements often lacking in human diets—iron, zinc, copper, calcium, magnesium, selenium and iodine. New Phytol 182:49–84 Also available via http://dx.doi.org/10.1111/j.1469-8137.2008.02738.x
WHO (2001) Macroeconomics and health: investing in health for economic development. World Health Organization, Geneva Also available via http://libdoc.who.int/publications/2001/924154550X.pdf (546 KB)
WHO (2002) The world health report 2002. World Health Organization, Geneva Also available via http://www.who.int/whr/2002/
WHO (2004) Vitamin and mineral requirements in human nutrition. World Health Organization, Geneva Also available via http://www.who.int/nutrition/publications/micronutrients/9241546123/
WHO (2009a) Micronutrient deficiencies: Iron deficiency anaemia. Web page of the World Health Organization, Geneva Available via http://www.who.int/nutrition/topics/ida/. Accessed 8 March 2009
WHO (2009b) Global burden of disease. Web page of the World Health Organization, Geneva Available via http://www.who.int/healthinfo/global_burden_disease/. Accessed 27 March 2009
Wolfe BL, Behrman JR (1983) Is income overrated in determining adequate nutrition? Econ Dev Cult Change 31:525–549 Also available via http://dx.doi.org/10.1086/451340
Wolson RA (2007) Assessing the prospects for the adoption of biofortified crops in South Africa. AgBioForum 10:184–191 Also available via http://www.agbioforum.org/v10n3/v10n3a08-wolson.htm
World Bank (1993) World development report 1993. World Bank, Washington, DC Also available via http://go.worldbank.org/6R5DC7G090
World Bank (1994) Enriching lives: Overcoming vitamin and mineral malnutrition in developing countries. World Bank, Washington, DC Also available via http://go.worldbank.org/N8B0YJMVB0
World Bank (2006) Repositioning nutrition as central to development: A strategy for large-scale action. World Bank, Washington, DC Also available via http://go.worldbank.org/M63XQNCQ20
Zhu C, Naqvi S, Gomez-Galera S, Pelacho AM, Capell T, Christou P (2007) Transgenic strategies for the nutritional enhancement of plants. Trends Plant Sci 12:548–555 Also available via http://dx.doi.org/10.1016/j.tplants.2007.09.007
Zhu Y-G, Pilon-Smits EAH, Zhao F-J, Williams PN, Meharg AA (2009) Selenium in higher plants: understanding mechanisms for biofortification and phytoremediation. Trends Plant Sci 14:436–442 Also available via http://dx.doi.org/10.1016/j.tplants.2009.06.006
Zimmermann R, Qaim M (2004) Potential health benefits of Golden Rice: a Philippine case study. Food Policy 29:147–168 Also available via http://dx.doi.org/10.1016/j.foodpol.2004.03.001
Acknowledgements
The author thanks Thomas Fellmann for revising the manuscript.
Author information
Authors and Affiliations
Corresponding author
Additional information
Responsible Editor: Ismail Cakmak.
Rights and permissions
About this article
Cite this article
Stein, A.J. Global impacts of human mineral malnutrition. Plant Soil 335, 133–154 (2010). https://doi.org/10.1007/s11104-009-0228-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11104-009-0228-2