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Effects of circadian disruption on the cardiometabolic system

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Abstract

The presence of day–night variations in cardiovascular and metabolic functioning is well known. However, only recently it has been shown that cardiovascular and metabolic processes are not only affected by the behavioral sleep/wake cycle but are partly under direct control of the master circadian pacemaker located in the suprachiasmatic nucleus (SCN). Heart rate, cardiac autonomic activity, glucose metabolism and leptin—involved in appetite control—all show circadian variation (i.e., under constant behavioral and environmental conditions). This knowledge of behavioral vs. circadian modulation of cardiometabolic function is of clinical relevance given the morning peak in adverse cardiovascular incidents observed in epidemiological studies and given the increased risk for the development of diabetes, obesity, and cardiovascular disease in shift workers. We will review the evidence for circadian control of cardiometabolic functioning, as well its sensitivity to light and melatonin, and discuss potential implication for therapy.

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Acknowledgements

The authors would like to thank Dr. Steven W. Lockley for initial discussion. M.R. was supported by National Institute of Neurological disorders and Stroke Grant 5R01NS54277-3 and National Institute of Mental Health Grant 5R01MH45130-19. F.A.J.L.S. was supported by National Center for Complementary and Alternative Medicine Grant R21-AT002713, and Biomedical Research Institute Fund to Sustain Research Excellence from Brigham and Women’s Hospital.

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  1. Division of Sleep Medicine, Harvard Medical School, Brigham and Women’s Hospital, 221 Longwood Avenue, Boston, MA, 02115, USA

    Melanie Rüger & Frank A. J. L. Scheer

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  1. Melanie Rüger
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Correspondence to Melanie Rüger.

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Rüger, M., Scheer, F.A.J.L. Effects of circadian disruption on the cardiometabolic system. Rev Endocr Metab Disord 10, 245–260 (2009). https://doi.org/10.1007/s11154-009-9122-8

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