Skip to main content
SpringerLink
Log in

How coupled are capillary electrophoresis and mass spectrometry?

  • Published:
Scientometrics Aims and scope Submit manuscript

Abstract

The understanding of how science works can contribute to making scientific development more effective. In this paper, we report an analysis of the organization and the interconnection between unbalanced areas of study. More specifically, we considered two important subareas in analytical chemistry, namely capillary electrophoresis (CE) and mass spectrometry (MS). These areas are particularly interesting because MS is employed in a bigger range of applications than CE. Consequently, these different portions of papers can interfere in the quality of the searches for papers devoted to CE–MS. Here, we considered a citation network in which the nodes and connections represent papers and citations, respectively. The network clusters were detected by employing the Infomap algorithm. By considering the clusters and the respective abstracts, the subjects were identified. Interesting results were found, including a marked separation between some clusters of articles devoted to instrumentation techniques and applications, which was quantified from the abstract contents. For instance, the most well-defined community was assigned as CE (Instru.), with 73.8% of the papers having abstracts that include the word “electrophoresis” and not the word “mass”. However, the papers that describe CE–MS did not lead to a well-defined cluster. In order to better understand the organization of the citation network, we considered a multi-scale analysis, in which we used the information regarding sub-clusters. Firstly, we analyzed the sub-cluster that contains the first article devoted to the coupling between CE and MS, whose subject was found to be a good representation of its sub-cluster. The second analysis was about the sub-cluster of a seminal paper known to be the first that dealt with protein analysis by using CE–MS and a similar result was obtained. By considering the proposed methodologies, our paper can contribute to researchers working with similar scenarios, since it shows that a given subject can be spread on many clusters of the network, therefore, lead to better literature reviews.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Notes

  1. https://www.microsoft.com/en-us/research/project/microsoft-academic-graph/.

References

  • Baker, D. R. (1995). Capillary electrophoresis. New York: Wiley.

    Google Scholar 

  • Blondel, V. D., Guillaume, J. L., Lambiotte, R., & Lefebvre, E. (2008). Fast unfolding of communities in large networks. Journal of statistical mechanics: Theory and experiment, 10, P10008.

    Article  Google Scholar 

  • Bornmann, L., Marx, W., Schier, H., Rahm, E., Thor, A., & Daniel, H. D. (2009). Convergent validity of bibliometric google scholar data in the field of chemistry–citation counts for papers that were accepted by angewandte chemie international edition or rejected but published elsewhere, using google scholar, science citation index, scopus, and chemical abstracts. Journal of informetrics, 3(127), 27–35.

    Article  Google Scholar 

  • Bornmann, L., Schier, H., Marx, W., & Daniel, H. D. (2012). What factors determine citation counts of publications in chemistry besides their quality? Journal of Informetrics,6(1), 11–18.

    Article  Google Scholar 

  • Braun, T., Schubert, A., & Schubert, G. (2001). Peer reviewed: The most cited books in analytical chemistry. Analytical Chemistry.

  • Burke, P.E., & da F Costa, L. (2019). Interdisciplinary relationships between biological and physical sciences. arXiv preprint arXiv:190503298.

  • Ceribeli, C., de Arruda, H.F., & Costa, L.d.F. (2019). How coupled are mass spectrometry and capillary electrophoresis? arXiv preprint arXiv:191013819.

  • de Arruda, H. F., Comin, C. H., & da F Costa L,. (2018). How integrated are theoretical and applied physics? Scientometrics,116(2), 1113–1121.

    Article  Google Scholar 

  • da F Costa L, Oliveira Jr ON, Travieso G, Rodrigues FA, Villas Boas PR, Antiqueira L, Viana MP, Correa Rocha LE,. (2011). Analyzing and modeling real-world phenomena with complex networks: A survey of applications. Advances in Physics, 60(3), 329–412.

    Article  Google Scholar 

  • Fortunato, S., Bergstrom, C. T., Börner, K., Evans, J. A., Helbing, D., Milojević, S., et al. (2018). Science of science. Science,. 359(6379), eaao0185.

    Article  Google Scholar 

  • Gohlke, R. S., & McLafferty, F. W. (1993). Early gas chromatography/mass spectrometry. Journal of the American Society for Mass Spectrometry,4(5), 367–371.

    Article  Google Scholar 

  • Haselberg, R., de Jong, G. J., & Somsen, G. W. (2007). Capillary electrophoresis-mass spectrometry for the analysis of intact proteins. Journal of Chromatography a,1159(1–2), 81–109.

    Article  Google Scholar 

  • Haselberg, R., de Jong, G. J., & Somsen, G. W. (2013). Low-flow sheathless capillary electrophoresis-mass spectrometry for sensitive glycoform profiling of intact pharmaceutical proteins. Analytical Chemistry, 85(4), 2289–2296.

    Article  Google Scholar 

  • Loo, J. A., Udseth, H. R., & Smith, R. D. (1989). Peptide and protein analysis by electrospray ionization-mass spectrometry and capillary electrophoresis-mass spectrometry. Analytical Biochemistry, 179(2), 404–412.

    Article  Google Scholar 

  • Manning, C. D., Manning, C. D., & Schütze, H. (1999). Foundations of statistical natural language processing. Cambridge: MIT Press.

    MATH  Google Scholar 

  • Mehrotra, S., & Goyal, V. (2013). Evaluation of designer crops for biosafety-a scientist’s perspective. Gene,515(2), 241–248.

    Article  Google Scholar 

  • Meyer, M., Debackere, K., & Glänzel, W. (2010). Can applied science be ‘good science’? Exploring the relationship between patent citations and citation impact in nanoscience. Scientometrics, 85(2), 527–539.

    Article  Google Scholar 

  • Monton, M. R. N., & Soga, T. (2007). Metabolome analysis by capillary electrophoresis-mass spectrometry. Journal of Chromatography A,1168(1–2), 237–246.

    Article  Google Scholar 

  • Nevídalová, H., Michalcová, L., & Glatz, Z. (2019). Capillary electrophoresis-based approaches for the study of affinity interactions combined with various sensitive and nontraditional detection techniques. Electrophoresis,40(5), 625–642.

    Article  Google Scholar 

  • Olivares, J. A., Nguyen, N. T., Yonker, C. R., & Smith, R. D. (1987). On-line mass spectrometric detection for capillary zone electrophoresis. Analytical Chemistry,59(8), 1230–1232.

    Article  Google Scholar 

  • Pavia, D. L., Lampman, G. M., Kriz, G. S., & Vyvyan, J. A. (2014). Introduction to spectroscopy. Cengage Learning.

    Google Scholar 

  • Pérez-Míguez, R., Salido-Fortuna, S., Castro-Puyana, M., & Marina, M. L. (2019). Advances in the determination of nonprotein amino acids in foods and biological samples by capillary electrophoresis. Critical Reviews in Analytical Chemistry, 49, 1–17.

    Article  Google Scholar 

  • Robledo, V. R., & Smyth, W. F. (2014). Review of the ce-ms platform as a powerful alternative to conventional couplings in bio-omics and target-based applications. Electrophoresis,35(16), 2292–2308.

    Article  Google Scholar 

  • Rodríguez, R., Mañes, J., & Picó, Y. (2003). Off-line solid-phase microextraction and capillary electrophoresis mass spectrometry to determine acidic pesticides in fruits. Analytical Chemistry, 75(3), 452–459.

    Article  Google Scholar 

  • Rosvall, M., & Bergstrom, C. T. (2008). Maps of random walks on complex networks reveal community structure. Proceedings of the National Academy of Sciences,105(4), 1118–1123.

    Article  Google Scholar 

  • Rosvall, M., & Bergstrom, C. T. (2010). Mapping change in large networks. PloS ONE, 5(1), e8694.

    Article  Google Scholar 

  • Rosvall, M., Axelsson, D., & Bergstrom, C. T. (2009). The map equation. The European Physical Journal Special Topics, 178(1), 13–23.

    Article  Google Scholar 

  • Schmitt-Kopplin, P., & Frommberger, M. (2003). Capillary electrophoresis-mass spectrometry: 15 years of developments and applications. Electrophoresis,24(22–23), 3837–3867.

    Article  Google Scholar 

  • Silva, F. N., Amancio, D. R., Bardosova, M., & da F Costa L, Oliveira Jr ON,. (2016). Using network science and text analytics to produce surveys in a scientific topic. Journal of Informetrics,10(2), 487–502.

    Article  Google Scholar 

  • Sinha, A., Shen, Z., Song, Y., Ma, H., Eide, D., Hsu, B.j.P., & Wang, K. (2015). An overview of microsoft academic service (mas) and applications. In Proceedings of the 24th international conference on world wide web, ACM, pp 243–246.

  • Smith, R. D., Olivares, J. A., Nguyen, N. T., & Udseth, H. R. (1988). Capillary zone electrophoresis-mass spectrometry using an electrospray ionization interface. Analytical Chemistry,60(5), 436–441.

    Article  Google Scholar 

  • Soga, T., Ohashi, Y., Ueno, Y., Naraoka, H., Tomita, M., & Nishioka, T. (2003). Quantitative metabolome analysis using capillary electrophoresis mass spectrometry. Journal of Proteome Research, 2(5), 488–494.

    Article  Google Scholar 

  • Taylor, H. E., & Taylor H. M. (2001). Inductively coupled plasma-mass spectrometry: practices and techniques. Cambridge: Academic Press.

    Google Scholar 

  • Wey, A. B., & Thormann, W. (2001). Head-column field-amplified sample stacking in presence of siphoning: Application to capillary electrophoresis-electrospray ionization mass spectrometry of opioids in urine. Journal of Chromatography A, 924(1–2), 507–518.

    Article  Google Scholar 

  • Zürbig, P., Renfrow, M. B., Schiffer, E., Novak, J., Walden, M., Wittke, S., et al. (2006). Biomarker discovery by CE–MS enables sequence analysis via ms/ms with platform-independent separation. Electrophoresis, 27(11), 2111–2125.

    Article  Google Scholar 

Download references

Acknowledgements

Caroline Ceribeli thanks Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. Henrique F. de Arruda acknowledges FAPESP for sponsorship (Grants No. 2018/10489-0 and no. 2019/16223-5). Luciano da F. Costa thanks CNPq (Grant No. 307085/2018-0) and NAP-PRP-USP for sponsorship. This work has been supported also by FAPESP Grants 11/50761-2 and 2015/22308-2. Research carried out using the computational resources of the Center for Mathematical Sciences Applied to Industry (CeMEAI) funded by FAPESP (Grant 2013/07375-0). The authors also thank Filipi Nascimento Silva for fruitful discussions and help concerning data. A preprint version of this paper can be found in arXiv Ceribeli et al. (2019), which can be accessed by arXiv:1910.13819.

Author information

Authors and Affiliations

  1. São Carlos Institute of Chemistry, University of São Paulo, São Carlos, SP, Brazil

    Caroline Ceribeli

  2. Department of Food Science, University of Copenhagen, Copenhagen, Denmark

    Caroline Ceribeli

  3. São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil

    Henrique Ferraz de Arruda & Luciano da Fontoura Costa

Authors
  1. Caroline Ceribeli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Henrique Ferraz de Arruda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Luciano da Fontoura Costa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Henrique Ferraz de Arruda.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ceribeli, C., Ferraz de Arruda, H. & da Fontoura Costa, L. How coupled are capillary electrophoresis and mass spectrometry?. Scientometrics 126, 3841–3851 (2021). https://doi.org/10.1007/s11192-021-03923-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11192-021-03923-0

Keywords

Search

Navigation