Abstract
A retrospective study on the outbreaks of foot-and-mouth disease (FMD) in Bhutan, between the years 1996 and 2008, based on the data collected through passive surveillance, was undertaken. A total of 230 outbreaks of FMD at sub-district level were recorded in 299 villages located in 19 out of the 20 districts in the country. There were no significant differences between the years (P = 0.998) or months (P = 0.989) on the incidence of FMD. The sub-districts in the north (altitude >1,000 m above mean sea level) had significantly (P = 0.008) higher incidences of outbreaks in winter than in summer. The sub-districts that shared border with India had significantly more outbreaks than those that didn't (P = 0.001). Cattle were the most predominant species affected being involved in all of the outbreaks reported. Serotype O, which constituted 70.6% of the outbreaks typed was the most predominant serotype prevalent in Bhutan followed by A (16.7%), Asia 1 (8.8%), and C (3.9%). Cattle density was significantly positively correlated (P = 0.023) with the incidence of disease. Three waves of outbreaks of epidemic proportions were reported in 1997/1998, 2002/2003, and 2007/2008 due to the PanAsia strain of the O serotype. The study highlights the incursion of the PanAsia strain of the O serotype into the country, possibly, through the transboundary movement of animals and the need for active surveillance of FMD, especially at the border areas. The study also highlights the significance of the O serotype and cattle as the main indicator species in the epidemiology of FMD in Bhutan. The findings from this study can be used as baseline epidemiological data for further research to understand the epidemiology of FMD in Bhutan.
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References
Anonymous, 2005. Policy and Operational Strategic Guidelines—Volume I. National Foot-and-Mouth Disease Prevention and Control Program. Department of Livestock, Ministry of Agriculture, Thimphu, Bhutan.
Anonymous, 2007a. Proceedings of the 9th Annual RNR Conference. Policy and Planning Division. Ministry of Agriculture, Lobeysa. Bhutan.
Anonymous, 2007b. Statistical Yearbook of Bhutan 2007. National Statistics Bureau. Royal Government of Bhutan., Thimphu, Bhutan.
Anonymous, 2009. Livestock Population and Production Bulletin (Data pertaining to year 2007). Department of Livestock, Ministry of Agriculture, Royal Government of Bhutan, Thimphu, Bhutan.
Ayebazibwe, C., TjØrnehØj, K., Mwiine, F.N., Muwanika, V.B., Ademun Okurut, A.R., Siegismund, H.R., and Alexandersen, S., 2010. Patterns, risk factors and characteristics of reported and perceived foot-and-mouth disease (FMD) in Uganda. Tropical Animal Health and Production, 1–13.
Basu, D.K., Bhattacharya, S., Saha, D., Chattopadhyay, A.P., Bhattacharya, D., and Sikdar, A., 1999. Report of an outbreak of foot-and-mouth disease in an organised dairy farm of West Bengal. Indian Journal of Animal Health, 38, 85–86.
Bhattacharya, S., Banerjee, R., Ghosh, R., Chattopadhayay, A.P., and Chatterjee, A., 2005. Studies of the outbreaks of foot and mouth disease in West Bengal, India, between 1985 and 2002. Revue Scientifique et Technique—Office International des Epizooties, 24, 945–952.
Davies, G., 2002. Foot and mouth disease. Research in Veterinary Science, 73, 195–199.
Dohms, J.E. and Metz, A., 1991. Stress—mechanisms of immunosuppression. Veterinary Immunology and Immunopathology, 30, 89–109.
Ferris, N.P., Donaldson, A., Shreshtra, R.M., and Kitching, R.P., 1992. A review of foot and mouth disease in Nepal. Scientific and Technical Review. Office International des Epizooties., 11, 685–698.
Hemadri, D., Tosh, C., Sanyal, A., and Venkataramanan, R., 2002. Emergence of a new strain of type O Foot-and-mouth disease virus: its phylogenetic and evolutionary relationship with the PanAsia pandemic strain. Virus Genes, 25, 23–34.
Khounsy, S., Conlan, J.V., Gleeson, L.J., Westbury, H.A., Colling, A., Paton, D.J., Knowles, N.J., Ferris, N.R., and Blacksell, S.D., 2008. Foot and mouth disease in the Lao People's Democratic Republic: I. A review of recent outbreaks and lessons from control programmes. Scientific and Technical Review. Office International des Epizooties., 27, 839–849.
Knowles, N.J. and Davies, P.R., 2002. Neighbour-joining tree depicting the genetic relationships between two viruses from Bhutan (isolated in 2002) and other FMD type O viruses. World Reference Laboratory for FMD., Pirbright, UK.
Knowles, N.J. and Samuel, A.R., 2003. Molecular epidemiology of foot-and-mouth disease virus. Virus Research, 91, 65–80.
Knowles, N.J. and Wadsworth, J. (2007) Report on FMD type O viruses from Bhutan in 2007. (http://www.wrlfmd.org/fmd_genotyping/asia/bhu.htm, Accessed on 17th November 2009.)
Knowles, N.J., Davies, P.R., and Valarcher, J.-F., 2004. Report on O Bhutan 2004. World Reference Laboratory for FMD. Pirbright, UK.
Knowles, N.J., Samuel, A.R., Davies, P.R., Midgley, R.J., and Valarcher, J.F., 2005. Pandemic strain of foot-and-mouth disease virus serotype O. Emerging Infectious Diseases, 11, 1887–1893.
Knowles, N.J., Wadsworth, J., and Ebert, K. (2008) Report on FMDV O from Bhutan in 2008. (http://www.wrlfmd.org/fmd_genotyping/asia/bhu.htm, Accessed on 17th November 2009.)
McLeod, R., 2003. Improved methods in diagnosis, epidemiology, and information management of foot-and-mouth disease in Southeast Asia. ACIAR Impact Assessment Series No. 21 Canberra.p24.
OIE, 2008. Chapter 2.1.5. Foot and Mouth Disease. In: Manual of Diagnostic Tests & Vaccines for Terrestrial Animals 6th Edition 2008. World Organisation for Animal Health (OIE), Paris, France.
Pallant, J., 2005. SPSS Survival Manual. A step by step guide to data analysis using SPSS for windows (version 12). 2nd edition. Allen & Unwin Crows Nest, NSW, Australia
Peralta, E.A., Carpenter, T.E., and Farver, T.B., 1982. The application of time series analysis to determine the pattern of foot-and-mouth disease in cattle in Paraguay. Preventive Veterinary Medicine, 1, 27–36.
Perry, B.D., Gleeson, L.J., Khounsey, S., Bounma, P., and Blacksell, S.D., 2002. The dynamics and impact of foot and mouth disease in smallholder farming systems in South-East Asia: a case study in Laos. Scientific and Technical Review. Office International des Epizooties., 21, 663–673.
Sangare, O., Dungu, B., and Bastos, A.D.S., 2004. Foot and mouth disease in Mali: the current situation and proposed control strategies. Scientific and Technical Review. Office International des Epizooties., 23, 863–872.
Sanjoy, S. and Sarma, D.K., 2005. Serological characterization of FMD virus type O isolates from field outbreaks in Assam. Indian Veterinary Journal, 82, 1025–1029.
Sarma, D.K. and Sutopa, D., 2003. FMD outbreaks and virus types in Assam and NE States, India between 1998 and 2001. Blue Cross Book, 16–18.
Schumann, K.R., Knowles, N.J., Davies, P.R., Midgley, R.J., Valarcher, J.F., Raoufi, A.Q., McKenna, T.S., Hurtle, W., Burans, J.P., Martin, B.M., Rodriguez, L.L., and Beckham, T.R., 2008. Genetic characterization and molecular epidemiology of foot-and-mouth disease viruses isolated from Afghanistan in 2003–2005. Virus Genes, 36, 401–413.
Sharma, M., 1992. Current status of foot and mouth disease in Bhutan. Bhutan Journal of Animal Husbandry, 13, 40–43.
Somparn, P., Gibb, M.J., Markvichitr, K., Chaiyabutr, N., Thummabood, S., and Vajrabukka, C., 2004. Analysis of climatic risk for cattle and buffalo production in northeast Thailand. International Journal of Biometeorology, 49, 59–64.
Sumption, K., Rweyemamu, M., and Wint, W., 2008. Incidence and distribution of foot-and-mouth disease in Asia, Africa and South America; combining expert opinion, official disease information and livestock populations to assist risk assessment. Transboundary and Emerging Diseases, 55, 5–13.
Thrusfield, M.V., 2005. Veterinary Epidemiology. Third Edn., Blackwell Science Ltd. Oxford. UK
Tshering, P., 2003. FMD and its control programme in Bhutan: A review. In, Proceedings of the Eighth National Livestock Research Coordination Workshop. 27–29 January 2003, Bumthang, Bhutan.
Verma, A.K., Pal, B.C., Singh, C.P., Udit, J., Yadav, S.K., and Mahima, 2008. Studies of the outbreaks of foot and mouth disease in Uttar Pradesh, India, between 2000 and 2006. Asian Journal of Epidemiology, 1, 40–46.
Acknowledgements
We would like to thank the Royal Government of Bhutan for facilitating the conduct of this research. We would also like to thank Dr. Tenzin, Karma Dekar, and Lokey Thapa for providing the outbreak data from the VIS database. Thanks are also extended to the WRLFMD at Pirbright, UK, for undertaking serotyping and molecular analysis of the samples. We wish to thank Evan Sergeant from the AusVet Animal Health Services, Australia for reviewing the manuscript. We also wish to thank the Australian Bio-security Cooperative Research Centre and Murdoch University, Australia, for funding this research.
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Dukpa, K., Robertson, I.D., Edwards, J.R. et al. A retrospective study on the epidemiology of foot-and-mouth disease in Bhutan. Trop Anim Health Prod 43, 495–502 (2011). https://doi.org/10.1007/s11250-010-9722-z
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DOI: https://doi.org/10.1007/s11250-010-9722-z