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Picrotoxane sesquiterpene and α-pyrone derivative from Dendrobium signatum and their free radical scavenging potency

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Abstract

One new picrotoxane sesquiterpene (1) and one new α-pyrone derivative (4), together with nine known compounds, were isolated from the aerial parts of Dendrobium signatum. The structures of the new compounds were elucidated based on the interpretation of 1D and 2D NMR, HRESIMS and electronic circular dichroism (ECD) data. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction data. The new α-pyrone 4 exhibited promising ABTS scavenging activity with IC50 value of 0.7 μM.

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Acknowledgements

This work was supported by The 90th Anniversary of Chulalongkorn University Fund (Ratchadaphiseksomphot Endownment Fund), the Research Assistantship Fund, Faculty of Science, Chulalongkorn University, and the Center of Excellence on Petrochemical and Materials Technology. T.A. was grateful to the Ratchadapisek Sompoch Endowment Fund (CU-GR_63_161_23_27), Chulalongkorn University for the partial support of X-ray diffraction facility.

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  1. Department of Chemistry, Faculty of Science, Chulalongkorn University, Patumwan, Bangkok, 10330, Thailand

    Prajak Khumploy, Achara Raksat, Siwattra Choodej, Thammarat Aree, Nattaya Ngamrojanavanich & Khanitha Pudhom

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  1. Prajak Khumploy
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  2. Achara Raksat
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  4. Thammarat Aree
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  6. Khanitha Pudhom
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Correspondence to Khanitha Pudhom.

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Khumploy, P., Raksat, A., Choodej, S. et al. Picrotoxane sesquiterpene and α-pyrone derivative from Dendrobium signatum and their free radical scavenging potency. J Nat Med 75, 967–974 (2021). https://doi.org/10.1007/s11418-021-01547-5

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  • DOI: https://doi.org/10.1007/s11418-021-01547-5

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