Skip to main content
Log in

Identification of N-ethyl-α-ethylphenethylamine in crystalline powder seized for suspected drug trafficking: a research chemical or a new designer drug?

  • Short Communication
  • Published:
Forensic Toxicology Aims and scope Submit manuscript

Abstract

A crystalline powder was found in an unclaimed lost article shipped from Vietnam to South Korea, and it was seized by narcotics agents as an item of suspicious trade. The chemical was suspected to be methamphetamine crystals, and was sent to the National Forensic Service for forensic identification. Elucidation of the chemical structure was carried out using gas chromatography–electron impact ionization–mass spectrometry, liquid chromatography–time-of-flight–mass spectrometry, and 1D and 2D nuclear magnetic resonance spectroscopy. The compound was identified as N-ethyl-α-ethylphenethylamine. Although the narcotic effect of this compound remains unverified, it may be classified as a phenethylamine-based designer drug on the basis of its structure. It appeared that the recipient of this article sought to abuse this chemical in the same way as amphetamines. There is a possibility that this chemical will be widely abused for recreational use in the near future.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Namera A, Nakamoto A, Saito T, Nagao M (2011) Colorimetric detection and chromatographic analyses of designer drugs in biological materials: a comprehensive review. Forensic Toxicol 29:1–24

    Article  CAS  Google Scholar 

  2. Auwärter V, Dresen S, Weinmann W, Müller M, Pütz M, Fereirós N (2009) ‘Spice’ and other herbal blends: harmless incense or cannabinoid designer drugs? J Mass Spectrom 44:832–837

    Article  PubMed  Google Scholar 

  3. Uchiyama N, Kawamura M, Kikura-Hanajiri R, Goda Y (2011) Identification and quantitation of two cannabimimetic phenylacetylindoles JWH-251 and JWH-250, and four cannabimimetic naphthoylidoles JWH-081, JWH-015, JWH-200, and JWH-073 as designer drugs in illegal products. Forensic Toxicol 29:25–37

    Article  CAS  Google Scholar 

  4. 2011 Annual report of the state of the drugs problem in Europe. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Lisbon, November 2011

  5. World Drug Report (2011) United Nations Office of Drugs and Crime (UNODC). June, Vienna 2011

    Google Scholar 

  6. Hillebrand J, Olszewski D, Sedefov R (2010) Legal highs on the Internet. Subst Use Misuse 45:330–340

    Article  PubMed  Google Scholar 

  7. Zaitsu K, Katagi M, Tatsuno M, Sato T, Tsuchihasi H, Suzuki K (2011) Recently abused β-keto derivatives of 3,4-methylenedioxyphenylalkylamines: a review of their metabolisms and toxicological analysis. Forensic Toxicol 29:73–84

    Article  CAS  Google Scholar 

  8. Zuba D (2012) Identification of cathinones and other active components of ‘legal highs’ by mass spectrometric methods. Trends Anal Chem 32:15–30

    Article  CAS  Google Scholar 

  9. Coppola M, Mondola R (2012) 3,4-Methylenedioxypyrovalerone (MDPV): chemistry, pharmacology and toxicology of a new designer drug of abuse marketed online. Toxicol Lett 208:12–15

    Article  PubMed  CAS  Google Scholar 

  10. Gibbons S, Zloh M (2010) An analysis of the ‘legal high’ mephedrone. Bioorg Med Chem Lett 20:4135–4139

    Article  PubMed  CAS  Google Scholar 

  11. Maheux CR, Copeland CR, Pollard MM (2010) Characterization of three methcathinone analogs: 4-methylmethcathinone, methylone, and bk-MBDB. Microgram J 7:42–49

    CAS  Google Scholar 

  12. Theobald DS, Maurer HH (2007) Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series). Biochem Pharmacol 73:287–297

    Article  PubMed  CAS  Google Scholar 

  13. Rösner P, Quednow B, Girreser U, Junge T (2005) Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs). Forensic Sci Int 148:143–156

    Article  PubMed  Google Scholar 

  14. Gosav S, Dinica R, Praisler M (2008) Choosing between GC–FTIR and GC–MS spectra for an efficient intelligent identification of illicit amphetamines. J Mol Struct 887:269–278

    Article  CAS  Google Scholar 

  15. Junet R (1956) Ethylamphetamine in the treatment of obesity. Praxis 45:986–988 (article in French)

    Google Scholar 

  16. Oberlender R, Nicholas DE (1991) Structural variation and (+)-amphetamine like discriminative stimulus properties. Pharmacol Biochem Behav 38:581–586

    Article  PubMed  CAS  Google Scholar 

  17. Nicholas DE (1986) Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens. Identification of a new therapeutic class: entactogens. J Psychoactive Drugs 18:305–313

    Article  Google Scholar 

  18. Misuse of Drugs Act 1971. Parliament of the United Kingdom, May 1971

Download references

Acknowledgments

This study was supported by funding from the National R&D Program of the Ministry of Education, Science, and Technology (2012-0009836) and the National Forensic Service of Korea.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jaesin Lee.

Additional information

This article is for the special issue TIAFT2012 edited by Osamu Suzuki.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, J., Choe, S., Choi, H. et al. Identification of N-ethyl-α-ethylphenethylamine in crystalline powder seized for suspected drug trafficking: a research chemical or a new designer drug?. Forensic Toxicol 31, 54–58 (2013). https://doi.org/10.1007/s11419-012-0158-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11419-012-0158-1

Keywords

Navigation