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Systematic Review of Thrombolysis Therapy in the Management of Non-Cirrhosis-Related Portal Vein Thrombosis

  • Review Article
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

Abstract

Purpose

To review available evidence to assess the efficacy and safety of thrombolysis therapy for non-cirrhosis-related portal vein thrombosis (PVT) that has not improved with anti-coagulation.

Methods

A literature search of databases MEDLINE, EMBASE, PUBMED, Cochrane and World Wide Web identified studies after 2000 utilizing portal vein thrombolysis in non-cirrhotic patients, with a minimum of 5 patients. Nine studies met criteria with 134 patients. The primary outcome evaluated was radiological re-canalization of the portal vein and symptomatic improvement post treatment. Secondary data points obtained included morbidity, mortality, thrombolysis approach and technique.

Results

The re-canalization rate following thrombolysis was 84% (0.67–1.02 CI 95%) and the symptomatic improvement rate 86% (0.70–1.01 CI 95%). The major complication rate was 7% (0.01–0.14 CI 95%) and the overall complication rate 25% (0.08–0.41 CI 95%). The direct and systemic thrombolysis approach showed no significant re-canalization rates with an odds ratio of 0.78 (0.24–2.55 CI 95%, P = 0.68). Thrombectomy in conjunction with thrombolysis demonstrated no improved patency or symptom relief with an odds ratio of 1 (0.17–6.03 CI 95%, P = 1.00).

Conclusion

Thrombolysis is an effective and safe therapy for portal vein thrombosis in non-cirrhotic patients where systemic anti-coagulation has failed. The heterogenicity of study thrombolysis protocols limits the evaluation of secondary outcomes, and future data should be standardized to determine the role of the thrombolysis access route and thrombectomy.

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Authors and Affiliations

  1. Department of Surgery, Blacktown Hospital, 14 Blacktown Rd, Blacktown, NSW, 2148, Australia

    Qiuye Cheng & Kevin Tree

  2. Discipline of Surgery, University of Western Sydney, Sydney, Australia

    Qiuye Cheng & Kevin Tree

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  1. Qiuye Cheng
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Cheng, Q., Tree, K. Systematic Review of Thrombolysis Therapy in the Management of Non-Cirrhosis-Related Portal Vein Thrombosis. J Gastrointest Surg 25, 1579–1590 (2021). https://doi.org/10.1007/s11605-020-04624-4

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