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Current advances for bone regeneration based on tissue engineering strategies

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Abstract

Bone tissue engineering (BTE) is a rapidly developing strategy for repairing critical-sized bone defects to address the unmet need for bone augmentation and skeletal repair. Effective therapies for bone regeneration primarily require the coordinated combination of innovative scaffolds, seed cells, and biological factors. However, current techniques in bone tissue engineering have not yet reached valid translation into clinical applications because of several limitations, such as weaker osteogenic differentiation, inadequate vascularization of scaffolds, and inefficient growth factor delivery. Therefore, further standardized protocols and innovative measures are required to overcome these shortcomings and facilitate the clinical application of these techniques to enhance bone regeneration. Given the deficiency of comprehensive studies in the development in BTE, our review systematically introduces the new types of biomimetic and bifunctional scaffolds. We describe the cell sources, biology of seed cells, growth factors, vascular development, and the interactions of relevant molecules. Furthermore, we discuss the challenges and perspectives that may propel the direction of future clinical delivery in bone regeneration.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 51673029, 81330043, and 81071499), Beijing Talent Fund (No. 2016000021223ZK34), and another fund (No. PXM2018_026275_000001).

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  1. Co-first authors: These authors have contributed equally to this work.

Authors and Affiliations

  1. Institute of Traumatology and Orthopaedics, Beijing Laboratory of Biomedical Materials, Beijing Jishuitan Hospital, Beijing, 100035, China

    Rui Shi, Chi Ma, Chengai Wu & Wei Tian

  2. Department of Spine Surgery of Beijing Jishuitan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, 100035, China

    Yuelong Huang & Wei Tian

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  1. Rui Shi
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  2. Yuelong Huang
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  3. Chi Ma
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  4. Chengai Wu
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Correspondence to Wei Tian.

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Shi, R., Huang, Y., Ma, C. et al. Current advances for bone regeneration based on tissue engineering strategies. Front. Med. 13, 160–188 (2019). https://doi.org/10.1007/s11684-018-0629-9

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