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Microfluidic extraction using two phase laminar flow for chemical and biological applications

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Abstract

We review the state of the art in microfluidic separation technique based two-phase laminar flow with an application focus on chemical and biological sample. As we describe herein, two-phase laminar flow in the microfluidic extraction has several biological and engineering advantages over other methods including high reproducibility, biocompatibility, and selectivity. We review advances in applications of two-phase laminar flow and examine key parameters such as flow rate, phase composition, and surface charge property, how these can affect extract performance with the technology including microfluidic separation system. A special technology focus is given to emerging novel integrative microfluidic extraction, which aims to merge aqueous phase laminar flow and electric field technologies into simple packages. We conclude with a brief discussion of some of the emerging challenges in the field and some of the approaches that are likely to enhance their application.

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Authors and Affiliations

  1. Division of Materials Science, Korea Basic Science Institute, Daejeon, 305-333, Korea

    Yun Suk Huh

  2. Biochemical team, GSCaltex R&D Center, Daejeon, 305-380, Korea

    Sang Jun Jeon

  3. Department of Chemical and Biomolecular Engineering (BK21 program), KAIST, 335 Gwahak-ro, Yuseong-gu, Daejeon, 305-701, Korea

    Eun Zoo Lee & Won Hi Hong

  4. Department of Chemical Engineering, College of Engineering, Kyung Hee University, 1 Seochon-dong, Giheung-gu, Yongin-si, Gyeonggi-do, 446-701, Korea

    Ho Seok Park

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  1. Yun Suk Huh
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  2. Sang Jun Jeon
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  3. Eun Zoo Lee
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  4. Ho Seok Park
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  5. Won Hi Hong
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Correspondence to Won Hi Hong.

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Prof. Won Hi Hong is a professor in the Department of Chemical and Biomolecular Engineering at KAIST. He received BS from Seoul National University, Dipl.-Ing and Dr.-Ing at Technical University Berlin, Germany. From 1980 to 1984, he worked as a researcher at TU Berlin and then he started as a senior researcher at KAIST in 1984 before joining as an assistant professor at KAIST. He received several awards for his excellent research activities form the Korean Society of Clean Technology, the Korean Institute of Chemical Engineers and the Ministry of Knowledge Economy. He is a member of KIChE, KSCT, VDI, ACS. His current professional fields of interest include extraction/purification of organic acid, CO2 absorption, direct methanol fuel cell, advanced nanomaterial and microfludic system for biosensor, and synthesis and application of nanostructured carbon nitride. As many as about 160 journal papers and 16 patents of his research achievements have been published so far.

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Huh, Y.S., Jeon, S.J., Lee, E.Z. et al. Microfluidic extraction using two phase laminar flow for chemical and biological applications. Korean J. Chem. Eng. 28, 633–642 (2011). https://doi.org/10.1007/s11814-010-0533-8

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