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Current Management of Angiosarcoma: Recent Advances and Lessons From the Past

  • Skin Cancer (T Ito, Section Editor)
  • Published:
Current Treatment Options in Oncology Aims and scope Submit manuscript

Opinion statement

Despite their rarity, angiosarcomas are one of the most aggressive soft tissue sarcomas. Management can often be challenging due to their location and infiltrative nature. A multidisciplinary treatment approach is always warranted, but the recurrence remains high even for localized tumors despite multimodality treatment. In the metastatic setting, cytotoxic chemotherapies, targeted therapies, and, more recently, immunotherapy are used. The sequence of systemic therapies remains currently a topic of active investigation. Over the last couple of years, there have been significant advances in understanding angiosarcoma biology, most notably via patient-driven initiatives like the Angiosarcoma Project. The knowledge derived from such translational work has led to identifying potential biomarkers of response to treatments and exploring new therapeutic avenues. More clinical trials are underway to expand treatment options and improve patient outcomes.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Oncology, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Salt Lake City, UT, USA

    Vaia Florou MD

  2. Department of Medicine, Division of Medical Oncology, University of Colorado School of Medicine, 1665 Aurora Court Anschutz Cancer Pavilion, Aurora, CO, USA

    Breelyn A. Wilky MD

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Correspondence to Vaia Florou MD.

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Vaia Florou declares that she has no conflict of interest.

Breelyn A. Wilky has received compensation from SpringWorks and Deciphera for service as a consultant.

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Florou, V., Wilky, B.A. Current Management of Angiosarcoma: Recent Advances and Lessons From the Past. Curr. Treat. Options in Oncol. 22, 61 (2021). https://doi.org/10.1007/s11864-021-00858-9

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