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Nonallergic rhinitis with eosinophilia syndrome

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Abstract

Nonallergic rhinitis with eosinophilia syndrome (NARES) is a clinical syndrome comprising symptoms consistent with allergic rhinitis in which an absence of atopy has been demonstrated by allergen skin testing, and nasal cytology analysis demonstrates more than 20% eosinophils. Anosmia is a prominent feature not shared with allergic rhinitis. The pathophysiology of NARES is poorly understood, but a key component involves a self-perpetuating, chronic eosinophilic nasal inflammation with development of nasal micropolyposis and polyposis. Mast cells likely play an important role as well. NARES is a risk factor for the development of nasal polyposis and aspirin sensitivity, as well as obstructive sleep apnea. Treatment consists mainly of intranasal corticosteroids with or without the addition of second-generation antihistamines and/or leukotriene-receptor antagonists.

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Authors and Affiliations

  1. Clinical Immunology and Allergy, Department of Medicine, McMaster University, 1200 Main Street West, HSC 3V48, L8N 3Z5, Hamilton, ON, Canada

    Paul K. Keith MD, MSc, FRCPC

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  1. Anne K. Ellis MD, FRCPC
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Correspondence to Paul K. Keith MD, MSc, FRCPC.

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Ellis, A.K., Keith, P.K. Nonallergic rhinitis with eosinophilia syndrome. Curr Allergy Asthma Rep 6, 215–220 (2006). https://doi.org/10.1007/s11882-006-0037-0

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