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Sporadic Multifocal Gastrinoma Mimicking a Duodenal GIST, in a Patient with MEN1 Gene Polymorphism D418D: an Unusual Case Report

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Fig. 1
Fig. 2

Data Availability

Upon request.

Abbreviations

CT:

Computed tomography

ECL:

Enterochromaffin-like cells

G:

Grade of histological differentiation

G-cell:

Gastrin-producing

5-HIAA:

5-Hydroxyindoleacetic acid

H. pylori :

Helicobacter pylori

MEN1:

Multiple Endocrine Neoplasia type 1

NET:

Neuroendocrine tumor

PPIs:

Proton-pump inhibitors

SMA:

Smooth muscle actin

ZES:

Zollinger–Ellison syndrome

References

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Acknowledgments

Genetic determinations were done at Hamamatsu University School of Medicine. The authors thank Ms. Keiko Ishino for genetic determinations.

Funding

This study was funded by Romanian National Authority for Scientific Research, CNCS–UEFISCDI, project number 20 PCCF/2018, code: PN-III-P4-ID-PCCF-2016-0006. The necessary materials were provided by the grant.

Author information

Author notes

  1. Simona Gurzu and Cristian Borz contributed equally to this work.

Authors and Affiliations

  1. Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, George Emil Palade, 38 Ghe Marinescu Street, 540139, Targu-Mures, Romania

    Simona Gurzu & Ioan Jung

  2. Department of Pathology, Clinical County Emergency Hospital, George Emil Palade, Targu-Mures, Romania

    Simona Gurzu & Andrei Patrichi

  3. Department of Pathology, Research Center of the University of Medicine, Pharmacy, Sciences and Technology, George Emil Palade, Targu-Mures, Romania

    Simona Gurzu

  4. Department of Surgery, University of Medicine, Pharmacy, Sciences and Technology, George Emil Palade, Targu-Mures, Romania

    Cristian Borz

  5. Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan

    Hidetaka Yamada & Haruhiko Sugimura

Authors
  1. Simona Gurzu
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  2. Ioan Jung
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  3. Cristian Borz
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  4. Andrei Patrichi
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  5. Hidetaka Yamada
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  6. Haruhiko Sugimura
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Contributions

SG drafted the paper and contributed to the histopathological diagnosis; IJ contributed to the histopathological diagnosis and interpretation of immunohistochemical data; CB established the clinical diagnosis and performed the surgical intervention; AP contributed to the revision of literature data; HY and HS performed the interpretation of genetic determinations; HS conferred the final approval for publication. All authors have read and approved the manuscript.

Corresponding author

Correspondence to Simona Gurzu.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

The approval of Ethical Committee of Clinical County Emergency Hospital of Targu Mures, Romania, was obtained for data collection.

Informed Consent

Signed informed consent for surgical intervention and publication of data was obtained before surgery.

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Gurzu, S., Jung, I., Borz, C. et al. Sporadic Multifocal Gastrinoma Mimicking a Duodenal GIST, in a Patient with MEN1 Gene Polymorphism D418D: an Unusual Case Report. J Gastrointest Canc 52, 351–354 (2021). https://doi.org/10.1007/s12029-020-00461-5

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  • DOI: https://doi.org/10.1007/s12029-020-00461-5

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